دورية أكاديمية
In-vitro assessment of first-line antifungal drugs against Aspergillus spp. caused human keratomycoses.
| العنوان: | In-vitro assessment of first-line antifungal drugs against Aspergillus spp. caused human keratomycoses. |
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| المؤلفون: | Hassan AS; Department of Microbiology, Dr. G.R. Damodaran College of Science, Coimbatore 641 014, India., Sangeetha AB; Department of Microbiology, PSG College of Arts & Science, Coimbatore 641 014, India., Shobana CS; Department of Microbiology, PSG College of Arts & Science, Coimbatore 641 014, India., Mythili A; Department of Microbiology, Dr. G.R. Damodaran College of Science, Coimbatore 641 014, India., Suresh S; Department of Microbiology, PSG College of Arts & Science, Coimbatore 641 014, India., Abirami B; Department of Microbiology, PSG College of Arts & Science, Coimbatore 641 014, India., Alharbi RA; Department of Public Health, College of Applied Medical Sciences, Majmaah University, Al Majmaah 11952, Saudi Arabia., Aloyuni SA; Department of Public Health, College of Applied Medical Sciences, Majmaah University, Al Majmaah 11952, Saudi Arabia., Abdel-Hadi A; Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, Al Majmaah 11952, Saudi Arabia; Botany and Microbiology Department, Faculty of Science, Al-Azhar University, Assiut Branch, Egypt., Awad MF; Department of Biology, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia; Botany and Microbiology Department, Faculty of Science, Al-Azhar University, Assiut Branch, Egypt., Ismail RM; Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, Al Majmaah 11952, Saudi Arabia; Microbiology and Immunology Department, Veterinary Research Division, National Research Center (NRC), Giza, Egypt., Panneer Selvam K; Department of Microbiology, M.R Government Arts College, Mannargudi 614 001, India., Manikandan P; Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, Al Majmaah 11952, Saudi Arabia; Greenlink Analytical and Research Laboratory India Private Limited, Coimbatore 641 014, India. Electronic address: m.palanisamy@mu.edu.sa. |
| المصدر: | Journal of infection and public health [J Infect Public Health] 2020 Dec; Vol. 13 (12), pp. 1907-1911. Date of Electronic Publication: 2020 Nov 06. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: England NLM ID: 101487384 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1876-035X (Electronic) Linking ISSN: 18760341 NLM ISO Abbreviation: J Infect Public Health Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford : Elsevier, 2008- |
| مواضيع طبية MeSH: | Corneal Ulcer*/drug therapy , Pharmaceutical Preparations*, Antifungal Agents/pharmacology ; Antifungal Agents/therapeutic use ; Aspergillus ; Humans ; India ; Microbial Sensitivity Tests ; Niger |
| مستخلص: | Background and Objectives: Aspergillus keratitis are in the increasing trend and reported as the second most common cause of mycotic keratitis in developing countries. The present study was designed to isolate, identify Aspergillus spp. from the keratits/corneal ulcer patients attending a tertiary care eye hospital, Coimbatore, South India and to assess the minimum inhibitory concentrations (MICs) against ten clinically used first-line antifungal drugs. Methods: A total of seventy-three Aspergillus strains isolated from corneal scrapings were included and assessed for a period of one year. All isolates were identified up to the species level by morphological observations. Antifungal drug susceptibilities were determined against a standard panel of antifungal agents. Conclusions: Five different species of aspergilli, A. flavus (n=53), A. fumigatus (n=14), A. terreus (n=9), A. tamarii (n=6) and A. niger (n=3) were identified based on morphological features. Minimum inhibitory concentration analyses indicated that, voriconazole, natamycin, itraconazole, clotrimazole, econazole followed by ketoconazole shall be the order of choices for the effective treatment for Aspergillus keratitis. (Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Aspergillus; Keratitis; Minimum inhibitory concentration; Natamycin; Voriconazole |
| المشرفين على المادة: | 0 (Antifungal Agents) 0 (Pharmaceutical Preparations) |
| تواريخ الأحداث: | Date Created: 20201109 Date Completed: 20210427 Latest Revision: 20210427 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.jiph.2020.10.014 |
| PMID: | 33162353 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1876-035X |
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| DOI: | 10.1016/j.jiph.2020.10.014 |