Photoacoustic and Magnetic Resonance Imaging of Hybrid Manganese Dioxide-Coated Ultra-small NaGdF 4 Nanoparticles for Spatiotemporal Modulation of Hypoxia in Head and Neck Cancer.

التفاصيل البيبلوغرافية
العنوان:	Photoacoustic and Magnetic Resonance Imaging of Hybrid Manganese Dioxide-Coated Ultra-small NaGdF 4 Nanoparticles for Spatiotemporal Modulation of Hypoxia in Head and Neck Cancer.
المؤلفون:	Rich LJ; Center for Oral Oncology, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY 14263, USA., Damasco JA; Department of Chemistry and the Institute for Lasers, Photonics, and Biophotonics, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA., Bulmahn JC; Department of Chemistry and the Institute for Lasers, Photonics, and Biophotonics, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA., Kutscher HL; Department of Chemistry and the Institute for Lasers, Photonics, and Biophotonics, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.; Department of Medicine, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.; Department of Anesthesiology, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA., Prasad PN; Department of Chemistry and the Institute for Lasers, Photonics, and Biophotonics, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA., Seshadri M; Center for Oral Oncology, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY 14263, USA.; Department of Dentistry and Maxillofacial Prosthetics, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY 14263, USA.
المصدر:	Cancers [Cancers (Basel)] 2020 Nov 06; Vol. 12 (11). Date of Electronic Publication: 2020 Nov 06.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: MDPI Country of Publication: Switzerland NLM ID: 101526829 Publication Model: Electronic Cited Medium: Print ISSN: 2072-6694 (Print) Linking ISSN: 20726694 NLM ISO Abbreviation: Cancers (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة:	Original Publication: Basel, Switzerland : MDPI
مستخلص:	There is widespread interest in developing agents to modify tumor hypoxia in head and neck squamous cell carcinomas (HNSCC). Here, we report on the synthesis, characterization, and potential utility of ultra-small NaYF 4 :Nd ³⁺ /NaGdF 4 nanocrystals coated with manganese dioxide (usNP-MnO 2 ) for spatiotemporal modulation of hypoxia in HNSCC. Using a dual modality imaging approach, we first visualized the release of Mn ²⁺ using T1-weighted magnetic resonance imaging (MRI) and modulation of oxygen saturation (%sO 2 ) using photoacoustic imaging (PAI) in vascular channel phantoms. Combined MRI and PAI performed in patient-derived HNSCC xenografts following local and systemic delivery of the hybrid nanoparticles enabled mapping of intratumoral nanoparticle accumulation (based on T1 contrast enhancement) and improvement in tumor oxygenation (increased %sO 2 ) within the tumor microenvironment. Our results demonstrate the potential of hybrid nanoparticles for the modulation of tumor hypoxia in head and neck cancer. Our findings also highlight the potential of combined MRI-PAI for simultaneous mapping nanoparticle delivery and oxygenation changes in tumors. Such imaging methods could be valuable in the precise selection of patients that are likely to benefit from hypoxia-modifying nanotherapies.
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معلومات مُعتمدة:	S10 OD010393 United States OD NIH HHS; R01DE024595 United States NH NIH HHS; S10OD010393 United States NH NIH HHS; KL2 TR001413 United States TR NCATS NIH HHS; P30CA016156 United States CA NCI NIH HHS
فهرسة مساهمة:	Keywords: MRI; head and neck cancer; manganese dioxide nanoparticles; photoacoustic imaging; tumor hypoxia
تواريخ الأحداث:	Date Created: 20201111 Latest Revision: 20211030
رمز التحديث:	20231215
مُعرف محوري في PubMed:	PMC7694772
DOI:	10.3390/cancers12113294
PMID:	33172178
قاعدة البيانات:	MEDLINE

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تدمد:	2072-6694
DOI:	10.3390/cancers12113294