The Spectrum of Helicobacter -Mediated Diseases.

التفاصيل البيبلوغرافية
العنوان:	The Spectrum of Helicobacter -Mediated Diseases.
المؤلفون:	Robinson K; National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust, Nottingham NG7 2UH, United Kingdom.; Nottingham Digestive Diseases Centre, University of Nottingham, Nottingham NG7 2RD United Kingdom; email: karen.robinson@nottingham.ac.uk., Atherton JC; National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust, Nottingham NG7 2UH, United Kingdom.; Nottingham Digestive Diseases Centre, University of Nottingham, Nottingham NG7 2RD United Kingdom; email: karen.robinson@nottingham.ac.uk.
المصدر:	Annual review of pathology [Annu Rev Pathol] 2021 Jan 24; Vol. 16, pp. 123-144. Date of Electronic Publication: 2020 Nov 16.
نوع المنشور:	Journal Article; Research Support, Non-U.S. Gov't; Review
اللغة:	English
بيانات الدورية:	Publisher: Annual Reviews Country of Publication: United States NLM ID: 101275111 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1553-4014 (Electronic) Linking ISSN: 15534006 NLM ISO Abbreviation: Annu Rev Pathol Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: Palo Alto, Calif. : Annual Reviews, c2006-
مواضيع طبية MeSH:	Helicobacter Infections/complications , Helicobacter Infections/drug therapy , Helicobacter Infections*/pathology, Drug Resistance, Microbial ; Helicobacter pylori ; Humans
مستخلص:	Helicobacter pylori is the leading cause of peptic ulcer disease. The infection has been implicated in more than 75% of duodenal ulcer cases and 17% of gastric ulcer cases. H. pylori has been classified as a human carcinogen, since it is the main cause of distal gastric adenocarcinoma and B cell mucosa-associated lymphoid tissue lymphoma. Evidence also links H. pylori with extragastric conditions including iron deficiency anemia, idiopathic thrombocytopenic purpura, and vitamin B 12 deficiency. Studies indicate that H. pylori may be protective against other conditions of the gastrointestinal tract (e.g., reflux esophagitis and related pathologies) and elsewhere in the body (e.g., asthma). The infection is asymptomatic in the vast majority of cases; more serious outcomes occur in only 10-15% of infected individuals. Despite extensive research over the past 3 decades, there is no effective vaccine, and the circumstances leading to disease development remain unclear. In addition, there is now a growing prevalence of antimicrobial resistance in H. pylori. This review discusses these important issues.
معلومات مُعتمدة:	G0601170 United Kingdom MRC_ Medical Research Council; MR/R026343/1 United Kingdom MRC_ Medical Research Council; MR/N001826/1 United Kingdom MRC_ Medical Research Council
فهرسة مساهمة:	Keywords: Helicobacter pylori; MALT lymphoma; antimicrobial resistance; duodenal ulcer; gastric adenocarcinoma; gastric ulcer; gastritis; reflux esophagitis
تواريخ الأحداث:	Date Created: 20201116 Date Completed: 20210331 Latest Revision: 20220317
رمز التحديث:	20231215
DOI:	10.1146/annurev-pathol-032520-024949
PMID:	33197219
قاعدة البيانات:	MEDLINE

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