دورية أكاديمية
GK-rats respond to gastric bypass surgery with improved glycemia despite unaffected insulin secretion and beta cell mass.
| العنوان: | GK-rats respond to gastric bypass surgery with improved glycemia despite unaffected insulin secretion and beta cell mass. |
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| المؤلفون: | Miskelly MG; Neuroendocrine Cell Biology, Lund University Diabetes Centre, Malmö, Sweden., Shcherbina L; Neuroendocrine Cell Biology, Lund University Diabetes Centre, Malmö, Sweden., Thorén Fischer AH; Neuroendocrine Cell Biology, Lund University Diabetes Centre, Malmö, Sweden., Abels M; Neuroendocrine Cell Biology, Lund University Diabetes Centre, Malmö, Sweden., Lindqvist A; Neuroendocrine Cell Biology, Lund University Diabetes Centre, Malmö, Sweden., Wierup N; Neuroendocrine Cell Biology, Lund University Diabetes Centre, Malmö, Sweden. Electronic address: nils.wierup@med.lu.se. |
| المصدر: | Peptides [Peptides] 2021 Feb; Vol. 136, pp. 170445. Date of Electronic Publication: 2020 Nov 13. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Inc Country of Publication: United States NLM ID: 8008690 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5169 (Electronic) Linking ISSN: 01969781 NLM ISO Abbreviation: Peptides Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York, NY : Elsevier Science Inc. Original Publication: Fayetteville, N. Y., Ankho International. |
| مواضيع طبية MeSH: | Diabetes Mellitus, Type 2/*genetics , Gastric Inhibitory Polypeptide/*genetics , Glucagon-Like Peptide 1/*genetics , Obesity, Morbid/*genetics, Animals ; Diabetes Mellitus, Type 2/metabolism ; Diabetes Mellitus, Type 2/pathology ; Diabetes Mellitus, Type 2/surgery ; Disease Models, Animal ; Gastric Bypass ; Glucose Tolerance Test ; Humans ; Insulin/genetics ; Insulin/metabolism ; Insulin Secretion/genetics ; Insulin-Secreting Cells/metabolism ; Insulin-Secreting Cells/pathology ; Islets of Langerhans/metabolism ; Islets of Langerhans/pathology ; Obesity, Morbid/metabolism ; Obesity, Morbid/pathology ; Obesity, Morbid/surgery ; Rats ; Rats, Wistar ; Weight Loss/genetics ; Weight Loss/physiology |
| مستخلص: | Roux-en-Y gastric bypass (RYGB) is the most effective treatment for morbid obesity and results in rapid remission of type 2 diabetes (T2D), before significant weight loss occurs. The underlying mechanisms for T2D remission are not fully understood. To gain insight into these mechanisms we used RYGB-operated diabetic GK-rats and Wistar control rats. Twelve adult male Wistar- and twelve adult male GK-rats were subjected to RYGB- or sham-operation. Oral glucose tolerance tests (OGTT) were performed six weeks after surgery. RYGB normalized fasting glucose levels in GK-rats, without affecting fasting insulin levels. In both rat strains, RYGB caused increased postprandial responses in glucose, GLP-1, and GIP. RYGB caused elevated postprandial insulin secretion in Wistar-rats, but had no effect on insulin secretion in GK-rats. In agreement with this, RYGB improved HOMA-IR in GK-rats, but had no effect on HOMA-β. RYGB-operated GK-rats had an increased number of GIP receptor and GLP-1 receptor immunoreactive islet cells, but RYGB had no major effect on beta or alpha cell mass. Furthermore, in RYGB-operated GK-rats, increased Slc5a1, Pck2 and Pfkfb1 and reduced Fasn hepatic mRNA expression was observed. In summary, our data shows that RYGB induces T2D remission and enhanced postprandial incretin hormone secretion in GK-rats, without affecting insulin secretion or beta cell mass. Thus our data question the dogmatic view of how T2D remission is achieved and instead point at improved insulin sensitivity as the main mechanism of remission. (Copyright © 2020 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: GIP; GK; GLP-1; Gastric bypass; Incretin receptor; Incretins; Insulin; Pancreas; RYGB; Roux-en-Y gastric bypass |
| المشرفين على المادة: | 0 (Insulin) 59392-49-3 (Gastric Inhibitory Polypeptide) 89750-14-1 (Glucagon-Like Peptide 1) |
| تواريخ الأحداث: | Date Created: 20201116 Date Completed: 20211203 Latest Revision: 20211214 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.peptides.2020.170445 |
| PMID: | 33197511 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-5169 |
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| DOI: | 10.1016/j.peptides.2020.170445 |