دورية أكاديمية
Copper(I) and silver(I) complexes of anthraldehyde thiosemicarbazone: synthesis, structure elucidation, in vitro anti-tuberculosis/cytotoxic activity and interactions with DNA/HSA.
| العنوان: | Copper(I) and silver(I) complexes of anthraldehyde thiosemicarbazone: synthesis, structure elucidation, in vitro anti-tuberculosis/cytotoxic activity and interactions with DNA/HSA. |
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| المؤلفون: | Khan A; School of Chemical Engineering and Physical Sciences, Lovely Professional University, Phagwara, Punjab, India. rekha.pardeep78@gmail.com., Paul K, Singh I, Jasinski JP, Smolenski VA, Hotchkiss EP, Kelley PT, Shalit ZA, Kaur M, Banerjee S, Roy P, Sharma R |
| المصدر: | Dalton transactions (Cambridge, England : 2003) [Dalton Trans] 2020 Dec 15; Vol. 49 (47), pp. 17350-17367. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101176026 Publication Model: Print Cited Medium: Internet ISSN: 1477-9234 (Electronic) Linking ISSN: 14779226 NLM ISO Abbreviation: Dalton Trans Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cambridge, UK : Royal Society of Chemistry, c2003- |
| مواضيع طبية MeSH: | Antineoplastic Agents/*pharmacology , Antitubercular Agents/*pharmacology , Coordination Complexes/*pharmacology , Mycobacterium tuberculosis/*drug effects , Tuberculosis, Pulmonary/*drug therapy, Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antitubercular Agents/chemical synthesis ; Antitubercular Agents/chemistry ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cells, Cultured ; Coordination Complexes/chemical synthesis ; Coordination Complexes/chemistry ; Copper/chemistry ; Copper/pharmacology ; Crystallography, X-Ray ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Microbial Sensitivity Tests ; Models, Molecular ; Molecular Structure ; Silver/chemistry ; Silver/pharmacology ; Structure-Activity Relationship |
| مستخلص: | A reaction of copper(i) halides (X = I, Br, Cl) and silver(i) halides with 9-anthraldehyde thiosemicarbazone (9-Hanttsc, H1L) and triphenylphosphine produced halogen-bridged dinuclear complexes, [M2(μ2-X)2(η1-S-9-Hanttsc)2(Ph3P)2] (M = Cu, X = Cl, 1; Br, 2; I, 3; M = Ag, X = Cl, 4; Br, 5). A similar reaction of 9-anthraldehyde-N1-methyl thiosemicarbazone (9-Hanttsc-N1-Me, H2L) with Ph3P and silver(i) halides yielded sulfur-bridged dimers, [Ag2X2(μ2-S-9-Hanttsc-N1-Me)2(Ph3P)2] (X = Cl, 9; Br, 10), however with copper(i) halides insoluble compounds were formed, which upon the addition of one extra mole of Ph3P gave mononuclear complexes of the formula [CuX(η1-S-9-Hanttsc-N1-Me)(Ph3P)2] (X = Cl, 6; Br, 7; I, 8). All of the complexes have been characterized by elemental analysis, NMR (1H, 13C) spectroscopy and single crystal X-ray crystallography (2, 5, 6, and 9). Both the ligands (H1L and H2L) and their complexes (1-10) were tested for their anti-tubercular and anticancer activities. The interactions of the ligands and their complexes (copper and silver) with calf thymus DNA (ct-DNA) and human serum albumin (HSA) were examined through UV-visible and fluorescence spectroscopy. Results showed that copper complex 2 displayed strong interactions with ct-DNA and HSA having binding constant values of 6.66 × 104 M-1 and 3.28 × 104 M-1, respectively, followed by silver complex 10 which gave binding constant values of 4.60 × 104 M-1 and 3.06 × 104 M-1, respectively. All of the complexes also showed good interactions with DNA in docking studies. |
| المشرفين على المادة: | 0 (Antineoplastic Agents) 0 (Antitubercular Agents) 0 (Coordination Complexes) 3M4G523W1G (Silver) 789U1901C5 (Copper) |
| تواريخ الأحداث: | Date Created: 20201119 Date Completed: 20210830 Latest Revision: 20210830 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1039/d0dt03104f |
| PMID: | 33210698 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1477-9234 |
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| DOI: | 10.1039/d0dt03104f |