دورية أكاديمية
أعرض في EDS

Antifungal activity of β-lapachone against azole-resistant Candida spp. and its aspects upon biofilm formation.

التفاصيل البيبلوغرافية
العنوان: Antifungal activity of β-lapachone against azole-resistant Candida spp. and its aspects upon biofilm formation.
المؤلفون: da Silva CR; Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Drug Research & Development Center, Federal University of Ceará, Fortaleza, CE 60430-275, Brazil.; Department of Clinical & Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE 60430-170, Brazil., S Campos R; Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Drug Research & Development Center, Federal University of Ceará, Fortaleza, CE 60430-275, Brazil.; Christus University Center (UNICHRISTUS), Fortaleza, CE 60160-230, Brazil., de A Neto JB; Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Drug Research & Development Center, Federal University of Ceará, Fortaleza, CE 60430-275, Brazil.; Christus University Center (UNICHRISTUS), Fortaleza, CE 60160-230, Brazil., Sampaio LS; Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Drug Research & Development Center, Federal University of Ceará, Fortaleza, CE 60430-275, Brazil.; Department of Clinical & Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE 60430-170, Brazil., do Nascimento FB; Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Drug Research & Development Center, Federal University of Ceará, Fortaleza, CE 60430-275, Brazil.; Department of Clinical & Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE 60430-170, Brazil., do Av Sá LG; Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Drug Research & Development Center, Federal University of Ceará, Fortaleza, CE 60430-275, Brazil.; Department of Clinical & Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE 60430-170, Brazil., Cândido TM; Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Drug Research & Development Center, Federal University of Ceará, Fortaleza, CE 60430-275, Brazil.; Department of Clinical & Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE 60430-170, Brazil., Magalhães HI; School of Pharmacy, Federal University of Paraíba, João Pessoa 58059-900, PB, Brazil., da Cruz EH; Laboratory of Synthetic & Heterocyclic Chemistry, Department of Chemistry, Institute of Exact Sciences, Federal University of Minas Gerais, Minas Gerais 31270-901, Brazil., da Silva Júnior EN; Laboratory of Synthetic & Heterocyclic Chemistry, Department of Chemistry, Institute of Exact Sciences, Federal University of Minas Gerais, Minas Gerais 31270-901, Brazil., de Moraes MO; Drug Research & Development Center, Federal University of Ceará, Fortaleza, CE 60430-275, Brazil., Cavalcanti BC; Drug Research & Development Center, Federal University of Ceará, Fortaleza, CE 60430-275, Brazil., Silva J; Departmentof Chemistry, Group of Theoretical Chemistry and Electrochemistry (GQTE), StateUniversity of Ceará, Limoeiro do Norte, Ceará 62930-000, Brazil., Marinho ES; Departmentof Chemistry, Group of Theoretical Chemistry and Electrochemistry (GQTE), StateUniversity of Ceará, Limoeiro do Norte, Ceará 62930-000, Brazil., Júnior HV; Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Drug Research & Development Center, Federal University of Ceará, Fortaleza, CE 60430-275, Brazil.; Department of Clinical & Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE 60430-170, Brazil.
المصدر: Future microbiology [Future Microbiol] 2020 Oct; Vol. 15, pp. 1543-1554. Date of Electronic Publication: 2020 Nov 20.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Future Medicine Country of Publication: England NLM ID: 101278120 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1746-0921 (Electronic) Linking ISSN: 17460913 NLM ISO Abbreviation: Future Microbiol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Future Medicine
مواضيع طبية MeSH: Drug Resistance, Fungal*, Antifungal Agents/*pharmacology , Azoles/*pharmacology , Biofilms/*drug effects , Candida/*drug effects , Naphthoquinones/*pharmacology, Candida/physiology ; Candidiasis/drug therapy ; Candidiasis/microbiology ; Humans ; Microbial Sensitivity Tests
مستخلص: Aim: The purpose of this study was to assess the antifungal effect of β-lapachone (β-lap) on azole-resistant strains of Candida spp. in both planktonic and biofilm form. Materials & methods: The antifungal activity of β-lap was evaluated by broth microdilution, flow cytometry and the comet assay. The cell viability of the biofilms was assessed using the MTT assay. Results: β-lap showed antifungal activity against resistant strains of Candida spp. in planktonic form. In addition, β-lap decreased the viability of mature biofilms and inhibited the formation of biofilms in vitro . Conclusion: β-lap showed antifungal activity against Candida spp., suggesting that the compound can be utilized as an adjunct agent in the treatment of candidiasis.
فهرسة مساهمة: Keywords: Candida spp.; biofilms; flow cytometry; mechanism of action; resistance; β-lapachone
المشرفين على المادة: 0 (Antifungal Agents)
0 (Azoles)
0 (Naphthoquinones)
6N4FA2QQ6A (beta-lapachone)
تواريخ الأحداث: Date Created: 20201120 Date Completed: 20211013 Latest Revision: 20220718
رمز التحديث: 20221213
DOI: 10.2217/fmb-2020-0011
PMID: 33215521
قاعدة البيانات: MEDLINE
الوصف
تدمد:1746-0921
DOI:10.2217/fmb-2020-0011