دورية أكاديمية
Mesenchymal stem cell therapy of acute thermal burns: A systematic review of the effect on inflammation and wound healing.
| العنوان: | Mesenchymal stem cell therapy of acute thermal burns: A systematic review of the effect on inflammation and wound healing. |
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| المؤلفون: | Rangatchew F; Department of Plastic Surgery and Burn Treatment, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. Electronic address: filip.rangatchew@hotmail.com., Vester-Glowinski P; Department of Plastic Surgery and Burn Treatment, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Rasmussen BS; Department of Plastic Surgery and Burn Treatment, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Haastrup E; Cell Therapy Facility, The Blood Bank, Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Munthe-Fog L; Cell Therapy Facility, The Blood Bank, Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Talman ML; Department of Pathology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Bonde C; Department of Plastic Surgery and Burn Treatment, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Drzewiecki KT; Department of Plastic Surgery and Burn Treatment, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Fischer-Nielsen A; Cell Therapy Facility, The Blood Bank, Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Holmgaard R; Department of Plastic Surgery and Burn Treatment, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. |
| المصدر: | Burns : journal of the International Society for Burn Injuries [Burns] 2021 Mar; Vol. 47 (2), pp. 270-294. Date of Electronic Publication: 2020 May 15. |
| نوع المنشور: | Journal Article; Review; Systematic Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8913178 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1409 (Electronic) Linking ISSN: 03054179 NLM ISO Abbreviation: Burns Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Elsevier Original Publication: [Guildford, Surrey, UK] : Butterworths, [c1989- |
| مواضيع طبية MeSH: | Burns*/therapy , Mesenchymal Stem Cell Transplantation* , Mesenchymal Stem Cells*, Animals ; Humans ; Inflammation/therapy ; Wound Healing |
| مستخلص: | Aim: Mesenchymal stem cell (MSC) therapies are emerging as a promising strategy to promote tissue repair, and may extend their utility to burn care. This comprehensive review of the extant literature, evaluated all in vivo studies, to elucidate the potential protective and therapeutic effect of MSCs in acute thermal skin burns. Methods: PubMed was systematically searched, according to PRISMA guidelines, and all relevant preclinical and clinical studies were included according to pre-specified eligibility criteria. Results: Forty-two studies were included in a qualitative synthesis, of which three were human and 39 were animal studies. The preclinical studies showed that MSCs can significantly reduce inflammation, burn wound progression and accelerate healing rate of acute burns. The underlying mechanisms are complex and not fully understood but paracrine modulators, such as immunomodulatory, antioxidative and trophic factors, seem to play important roles. Allogeneic MSC therapy has proved feasible in humans, and could allow for prompt treatment of acute burns in a clinical setting. Conclusion: MSC therapy show positive results, regarding improved burn wound healing and immunologic response. However, most findings are based on small animal studies. Randomized clinical trials are warranted to investigate the regenerative effects in human burns before translating the findings into clinical practice. (Copyright © 2020 Elsevier Ltd and ISBI. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Burn therapy; Burns; Cell therapy; Mesenchymal stem cells; Regenerative medicine; Wound healing |
| تواريخ الأحداث: | Date Created: 20201121 Date Completed: 20211123 Latest Revision: 20211123 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.burns.2020.04.012 |
| PMID: | 33218945 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1879-1409 |
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| DOI: | 10.1016/j.burns.2020.04.012 |