دورية أكاديمية
Effect of disease related biases on the subjective assessment of social functioning in Alzheimer's disease and schizophrenia patients.
| العنوان: | Effect of disease related biases on the subjective assessment of social functioning in Alzheimer's disease and schizophrenia patients. |
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| المؤلفون: | Jongs N; Groningen Institute for Evolutionary Life Sciences, University of Groningen, the Netherlands., Penninx B; Department of Psychiatry and Amsterdam Neuroscience, VU University Medical Center, Amsterdam, the Netherlands., Arango C; Institute of Psychiatry and Mental Health, Department of Child and Adolescent Psychiatry, Hospital General Universitario Gregorio Marañón, CIBERSAM, IiSGM, Universidad Complutense, School of Medicine, Madrid, Spain., Ayuso-Mateos JL; Department of Psychiatry, Universidad Autónoma de Madrid, Madrid, Spain; Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Instituto de Salud Carlos III, Madrid, Spain; Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-Princesa), Madrid, Spain., van der Wee N; Department of Psychiatry, Leiden University Medical Center, the Netherlands; Leiden Institute for Brain and Cognition/Psychiatric Neuroimaging, Leiden University Medical Center, the Netherlands., Rossum IW; University Medical Centre Utrecht, Department of Psychiatry, Brain Center Rudolf Magnus, Utrecht, the Netherlands., Saris IMJ; Department of Psychiatry and Amsterdam Neuroscience, VU University Medical Center, Amsterdam, the Netherlands., van Echteld A; University Medical Centre Utrecht, Department of Psychiatry, Brain Center Rudolf Magnus, Utrecht, the Netherlands., Koops S; University Medical Centre Utrecht, Department of Psychiatry, Brain Center Rudolf Magnus, Utrecht, the Netherlands., Bilderbeck AC; P1vital Ltd., Wallingford, Oxfordshire, United Kingdom., Raslescu A; P1vital Ltd., Wallingford, Oxfordshire, United Kingdom., Dawson GR; P1vital Ltd., Wallingford, Oxfordshire, United Kingdom., Sommer B; Boehringer Ingelheim Pharma GmbH & Co KG, CNS Diseases Research, Biberach an der Riss, Germany., Marston H; External Neurodegenerative Research, Eli Lilly and Company, Windlesham, United Kingdom., Vorstman JA; The Hospital for Sick Children, University of Toronto, Toronto, Canada., Eijkemans MJ; Julius Center for Health Sciences and Primary Care, Department of Biostatistics and Research Support, University Medical Center Utrecht, the Netherlands., Kas MJ; Groningen Institute for Evolutionary Life Sciences, University of Groningen, the Netherlands. Electronic address: m.j.h.kas@rug.nl. |
| المصدر: | Journal of psychiatric research [J Psychiatr Res] 2022 Jan; Vol. 145, pp. 302-308. Date of Electronic Publication: 2020 Nov 09. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Pergamon Press Country of Publication: England NLM ID: 0376331 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1379 (Electronic) Linking ISSN: 00223956 NLM ISO Abbreviation: J Psychiatr Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford : Pergamon Press |
| مواضيع طبية MeSH: | Alzheimer Disease*/complications , Alzheimer Disease*/psychology , Schizophrenia*/complications, Bias ; Caregivers/psychology ; Humans ; Social Interaction |
| مستخلص: | Background: Questionnaires are the current hallmark for quantifying social functioning in human clinical research. In this study, we compared self- and proxy-rated (caregiver and researcher) assessments of social functioning in Schizophrenia (SZ) and Alzheimer's disease (AD) patients and evaluated if the discrepancy between the two assessments is mediated by disease-related factors such as symptom severity. Methods: We selected five items from the WHO Disability Assessment Schedule 2.0 (WHODAS) to assess social functioning in 53 AD and 61 SZ patients. Caregiver- and researcher-rated assessments of social functioning were used to calculate the discrepancies between self-rated and proxy-rated assessments. Furthermore, we used the number of communication events via smartphones to compare the questionnaire outcomes with an objective measure of social behaviour. Results: WHODAS results revealed that both AD (p < 0.001) and SZ (p < 0.004) patients significantly overestimate their social functioning relative to the assessment of their caregivers and/or researchers. This overestimation is mediated by the severity of cognitive impairments (MMSE; p = 0.019) in AD, and negative symptoms (PANSS; p = 0.028) in SZ. Subsequently, we showed that the proxy scores correlated more strongly with the smartphone communication events of the patient when compared to the patient-rated questionnaire scores (self; p = 0.076, caregiver; p < 0.001, researcher-rated; p = 0.046). Conclusion: Here we show that the observed overestimation of WHODAS social functioning scores in AD and SZ patients is partly driven by disease-related biases such as cognitive impairments and negative symptoms, respectively. Therefore, we postulate the development and implementation of objective measures of social functioning that may be less susceptible to such biases. (Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.) |
| تواريخ الأحداث: | Date Created: 20201122 Date Completed: 20220316 Latest Revision: 20220316 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.jpsychires.2020.11.013 |
| PMID: | 33221026 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1879-1379 |
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| DOI: | 10.1016/j.jpsychires.2020.11.013 |