دورية أكاديمية
L-lactate induces neurogenesis in the mouse ventricular-subventricular zone via the lactate receptor HCA 1 .
| العنوان: | L-lactate induces neurogenesis in the mouse ventricular-subventricular zone via the lactate receptor HCA |
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| المؤلفون: | Lambertus M; Section for Pharmacology and Pharmaceutical Biosciences, Department of Pharmacy, The Faculty of Mathematics and Natural Sciences, University of Oslo, Oslo, Norway., Øverberg LT; Section for Pharmacology and Pharmaceutical Biosciences, Department of Pharmacy, The Faculty of Mathematics and Natural Sciences, University of Oslo, Oslo, Norway.; Institute for Behavioural Sciences, Faculty of Health Sciences, OsloMet-Oslo Metropolitan University, Oslo, Norway., Andersson KA; The Brain and Muscle Energy Group, Electron Microscopy Laboratory, Institute of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway.; Division of Anatomy, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway., Hjelden MS; Section for Pharmacology and Pharmaceutical Biosciences, Department of Pharmacy, The Faculty of Mathematics and Natural Sciences, University of Oslo, Oslo, Norway., Hadzic A; Section for Pharmacology and Pharmaceutical Biosciences, Department of Pharmacy, The Faculty of Mathematics and Natural Sciences, University of Oslo, Oslo, Norway., Haugen ØP; The Brain and Muscle Energy Group, Electron Microscopy Laboratory, Institute of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway., Storm-Mathisen J; Division of Anatomy, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway., Bergersen LH; The Brain and Muscle Energy Group, Electron Microscopy Laboratory, Institute of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway.; Center for Healthy Aging, Department of Neuroscience and Pharmacology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark., Geiseler S; Section for Pharmacology and Pharmaceutical Biosciences, Department of Pharmacy, The Faculty of Mathematics and Natural Sciences, University of Oslo, Oslo, Norway., Morland C; Section for Pharmacology and Pharmaceutical Biosciences, Department of Pharmacy, The Faculty of Mathematics and Natural Sciences, University of Oslo, Oslo, Norway.; Institute for Behavioural Sciences, Faculty of Health Sciences, OsloMet-Oslo Metropolitan University, Oslo, Norway. |
| المصدر: | Acta physiologica (Oxford, England) [Acta Physiol (Oxf)] 2021 Mar; Vol. 231 (3), pp. e13587. Date of Electronic Publication: 2020 Dec 06. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101262545 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1748-1716 (Electronic) Linking ISSN: 17481708 NLM ISO Abbreviation: Acta Physiol (Oxf) Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford : Wiley-Blackwell Original Publication: Oxford : Blackwell Pub., c2006-4 |
| مواضيع طبية MeSH: | Lateral Ventricles* , Neural Stem Cells*, Animals ; Cell Proliferation ; Lactic Acid ; Mice ; Mice, Knockout ; Neurogenesis |
| مستخلص: | Aim: Adult neurogenesis occurs in two major niches in the brain: the subgranular zone of the hippocampal formation and the ventricular-subventricular zone. Neurogenesis in both niches is reduced in ageing and neurological disease involving dementia. Exercise can rescue memory by enhancing hippocampal neurogenesis, but whether exercise affects adult neurogenesis in the ventricular-subventricular zone remains unresolved. Previously, we reported that exercise induces angiogenesis through activation of the lactate receptor HCA1. The aim of the present study is to investigate HCA Methods: Wild-type and HCA Results: We demonstrated that neurogenesis in the ventricular-subventricular zone is enhanced by HCA Conclusion: Our study demonstrates that neurogenesis in the two main neurogenic niches in the brain is regulated differently: Neurogenesis in both niches was induced by exercise, but only in the ventricular-subventricular zone was neurogenesis induced by lactate through HCA (© 2020 Scandinavian Physiological Society. Published by John Wiley & Sons Ltd.) |
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| فهرسة مساهمة: | Keywords: GPR81; HCA1; HCAR1; adult neurogenesis; exercise; lactate |
| سلسلة جزيئية: | RefSeq RRID:SCR_003070; RRID:SCR_002865 |
| المشرفين على المادة: | 33X04XA5AT (Lactic Acid) |
| تواريخ الأحداث: | Date Created: 20201127 Date Completed: 20210818 Latest Revision: 20210818 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1111/apha.13587 |
| PMID: | 33244894 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1748-1716 |
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| DOI: | 10.1111/apha.13587 |