دورية أكاديمية
أعرض في EDS

A comprehensive and contemporary "snapshot" of β-lactamases in carbapenem resistant Acinetobacter baumannii.

التفاصيل البيبلوغرافية
العنوان: A comprehensive and contemporary "snapshot" of β-lactamases in carbapenem resistant Acinetobacter baumannii.
المؤلفون: Hujer AM; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, USA; Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH, USA., Hujer KM; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, USA; Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH, USA., Leonard DA; Department of Chemistry, Grand Valley State University, Allendale, MI, USA., Powers RA; Department of Chemistry, Grand Valley State University, Allendale, MI, USA., Wallar BJ; Department of Chemistry, Grand Valley State University, Allendale, MI, USA., Mack AR; Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH, USA; Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, OH, USA., Taracila MA; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, USA; Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH, USA., Rather PN; Research Service, Atlanta Veterans Medical Center, Decatur, GA, USA; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA; Emory Antibiotic Resistance Center, Emory University School of Medicine, Atlanta, GA, USA., Higgins PG; Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Cologne, Germany; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Germany., Prati F; Department of Life Science, University of Modena and Reggio Emilia, Modena, Italy., Caselli E; Department of Life Science, University of Modena and Reggio Emilia, Modena, Italy., Marshall SH; Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH, USA., Clarke T; J. Craig Venter Institute, Rockville, MD, USA., Greco C; J. Craig Venter Institute, Rockville, MD, USA., Venepally P; J. Craig Venter Institute, Rockville, MD, USA., Brinkac L; Noblis, Reston, VA, USA., Kreiswirth BN; Hackensack Meridian Health, Center for Discovery and Innovation, Nutley, NJ, USA., Fouts DE; J. Craig Venter Institute, Rockville, MD, USA., Bonomo RA; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, USA; Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH, USA; Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, OH, USA; Departments of Biochemistry, Pharmacology, and Proteomics and Bioinformatics, Case Western Reserve University School of Medicine, Cleveland, OH, USA; CWRU-Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology (Case VA CARES) Cleveland, OH, USA. Electronic address: robert.bonomo@va.gov.
مؤلفون مشاركون: Antibacterial Resistance Leadership Group (ARLG)
المصدر: Diagnostic microbiology and infectious disease [Diagn Microbiol Infect Dis] 2021 Feb; Vol. 99 (2), pp. 115242. Date of Electronic Publication: 2020 Oct 16.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Biomedical Country of Publication: United States NLM ID: 8305899 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0070 (Electronic) Linking ISSN: 07328893 NLM ISO Abbreviation: Diagn Microbiol Infect Dis Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [New York, NY] : Elsevier Biomedical, [c1983-
مواضيع طبية MeSH: Acinetobacter baumannii/*genetics , Bacterial Proteins/*genetics , Carbapenems/*pharmacology , beta-Lactam Resistance/*genetics , beta-Lactamases/*genetics, Acinetobacter Infections/microbiology ; Acinetobacter baumannii/enzymology ; Acinetobacter baumannii/isolation & purification ; Genome, Bacterial/genetics ; Humans
مستخلص: Successful treatment of Acinetobacter baumannii infections require early and appropriate antimicrobial therapy. One of the first steps in this process is understanding which β-lactamase (bla) alleles are present and in what combinations. Thus, we performed WGS on 98 carbapenem-resistant A. baumannii (CR Ab). In most isolates, an acquired bla OXA carbapenemase was found in addition to the intrinsic bla OXA allele. The most commonly found allele was bla OXA-23 (n = 78/98). In some isolates, bla OXA-23 was found in addition to other carbapenemase alleles: bla OXA-82 (n = 12/78), bla OXA-72 (n = 2/78) and bla OXA-24/40 (n = 1/78). Surprisingly, 20% of isolates carried carbapenemases not routinely assayed for by rapid molecular diagnostic platforms, i.e., bla OXA-82 and bla OXA-172 ; all had ISAba1 elements. In 8 CR Ab, bla OXA-82 or bla OXA-172 was the only carbapenemase. Both bla OXA-24/40 and its variant bla OXA-72 were each found in 6/98 isolates. The most prevalent ADC variants were bla ADC-30 (21%), bla ADC-162 (21%), and bla ADC-212 (26%). Complete combinations are reported.
(Published by Elsevier Inc.)
معلومات مُعتمدة: IK6 BX004470 United States BX BLRD VA; R01 AI072219 United States AI NIAID NIH HHS; U19 AI110819 United States AI NIAID NIH HHS; UM1 AI104681 United States AI NIAID NIH HHS
فهرسة مساهمة: Keywords: ADC β-lactamase; Carbapenem resistant Acinetobacter baumannii; OXA carbapenemase; OXA-172; OXA-23; OXA-82
المشرفين على المادة: 0 (Bacterial Proteins)
0 (Carbapenems)
EC 3.5.2.6 (beta-Lactamases)
تواريخ الأحداث: Date Created: 20201128 Date Completed: 20210712 Latest Revision: 20210918
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC7562987
DOI: 10.1016/j.diagmicrobio.2020.115242
PMID: 33248392
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-0070
DOI:10.1016/j.diagmicrobio.2020.115242