دورية أكاديمية
Detraining effects after 18 months of high intensity resistance training on osteosarcopenia in older men-Six-month follow-up of the randomized controlled Franconian Osteopenia and Sarcopenia Trial (FrOST).
| العنوان: | Detraining effects after 18 months of high intensity resistance training on osteosarcopenia in older men-Six-month follow-up of the randomized controlled Franconian Osteopenia and Sarcopenia Trial (FrOST). |
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| المؤلفون: | Kemmler W; Institute of Medical Physics, Friedrich-Alexander University of Erlangen-Nürnberg, 91052 Erlangen, Germany. Electronic address: wolfgang.kemmler@imp.uni-erlangen.de., Kohl M; Faculty Medical and Life Sciences, University of Furtwangen, 78054 Villingen-Schwenningen, Germany. Electronic address: Matthias.Kohl@hs-furtwangen.de., Fröhlich M; Department of Sports Science, University of Kaiserslautern, 67663 Kaiserslautern, Germany. Electronic address: michael.froehlich@sowi.uni-kl.de., Schoene D; Institute of Medical Physics, Friedrich-Alexander University of Erlangen-Nürnberg, 91052 Erlangen, Germany. Electronic address: daniel.schoene@fau.de., von Stengel S; Institute of Medical Physics, Friedrich-Alexander University of Erlangen-Nürnberg, 91052 Erlangen, Germany. Electronic address: simon.von.stengel@imp.uni-erlangen.de. |
| المصدر: | Bone [Bone] 2021 Jan; Vol. 142, pp. 115772. Date of Electronic Publication: 2020 Nov 26. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: United States NLM ID: 8504048 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2763 (Electronic) Linking ISSN: 18732763 NLM ISO Abbreviation: Bone Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York : Elsevier Science Original Publication: Elmsford, NY : Pergamon Press, c1985- |
| مواضيع طبية MeSH: | Bone Diseases, Metabolic*/therapy , Resistance Training* , Sarcopenia*, Aged ; Bone Density ; Follow-Up Studies ; Hand Strength ; Humans ; Male ; Muscle Strength ; Muscle, Skeletal |
| مستخلص: | Purpose: Detraining after dedicated exercise programs might be a frequent situation in older people's exercise patterns. The aim of the present study was thus to determine the effects of 6 months of detraining after 18 months of high intensity resistance exercise (HIT-RT) on musculoskeletal outcomes in older men with sarcopenia. Methods: Community-dwelling men aged 72 years and older with osteosarcopenia (n = 43) were randomly assigned to an 18-month HIT-RT (EG: n = 21) or a non-training control group (CG, n = 22). After the intervention, participants of the EG stopped HIT-RT for 6 months, but continued their habitual physical activity. Study outcomes were skeletal muscle mass index, bone mineral density (BMD) at the lumbar-spine and total-hip, maximum hip/leg-extensor strength, handgrip strength and gait velocity. We applied an intention-to-treat analysis with multiple imputation. Results: Changes in the HIT-RT were much more pronounced during the detraining period compared with the CG, although this effect was only significant for skeletal muscle mass index and hip-/leg-extensor strength (p = .002 and p = .013), but not for lumbar-spine BMD (p = .068), total-hip BMD (p = .069), handgrip strength (p = .066) or gait velocity (p = .067). Apart from total-hip BMD (p = .055), handgrip strength (p = .069) and gait velocity (p = .881) values of the HIT-RT group decreased significantly during detraining. However, after 24 months, overall effects (p < .001) were still observed for skeletal muscle mass index and hip-/leg-extensor strength. Conclusion: Although unable to state from which point in time relevant detraining effects emerge, we conclude that health care providers should focus on continuous rather than intermitted exercise programs for older people. Clinical trial number: clinicalTrials.gov: NCT03453463; NCT04444661. (Copyright © 2020 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Bone mineral density; Detraining; Older men; Resistance exercise; Sarcopenia |
| سلسلة جزيئية: | ClinicalTrials.gov NCT03453463; NCT04444661 |
| تواريخ الأحداث: | Date Created: 20201129 Date Completed: 20210617 Latest Revision: 20210617 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1016/j.bone.2020.115772 |
| PMID: | 33249320 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1873-2763 |
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| DOI: | 10.1016/j.bone.2020.115772 |