التفاصيل البيبلوغرافية
| العنوان: |
When a House Is Not a Home: A Survey of Antimetastatic Niches and Potential Mechanisms of Disseminated Tumor Cell Suppression. |
| المؤلفون: |
Crist SB; Public Health Sciences Division/Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA; email: scrist@fredhutch.org, cghajar@fredhutch.org.; Program in Molecular and Cellular Biology, University of Washington, Seattle, Washington 98105, USA., Ghajar CM; Public Health Sciences Division/Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA; email: scrist@fredhutch.org, cghajar@fredhutch.org. |
| المصدر: |
Annual review of pathology [Annu Rev Pathol] 2021 Jan 24; Vol. 16, pp. 409-432. Date of Electronic Publication: 2020 Dec 04. |
| نوع المنشور: |
Journal Article; Review |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: Annual Reviews Country of Publication: United States NLM ID: 101275111 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1553-4014 (Electronic) Linking ISSN: 15534006 NLM ISO Abbreviation: Annu Rev Pathol Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Palo Alto, Calif. : Annual Reviews, c2006- |
| مواضيع طبية MeSH: |
Tumor Microenvironment*, Neoplasm Invasiveness/*pathology , Neoplasms/*pathology, Animals ; Humans |
| مستخلص: |
Over the last four decades, the cancer biology field has concentrated on cellular and microenvironmental drivers of metastasis. Despite this focus, mortality rates upon diagnosis of metastatic disease remain essentially unchanged. Would a small change in perspective help? Knowing what constitutes an inhospitable, rather than hospitable, microenvironment could provide the inspiration necessary to develop better therapies and preventative strategies. In this review, we canvas the literature for hints about what characteristics four common antimetastatic niches-skeletal muscle, spleen, thyroid, and yellow bone marrow-have in common. We posit that thorough molecular and mechanistic characterization of antimetastatic tissues may inspire reimagined therapies that inhibit metastatic development and/or progression in an enduring manner. |
| فهرسة مساهمة: |
Keywords: DTC; antimetastatic niche; disseminated tumor cell; metastasis; microenvironment; tumor dormancy |
| تواريخ الأحداث: |
Date Created: 20201205 Date Completed: 20210331 Latest Revision: 20210331 |
| رمز التحديث: |
20231215 |
| DOI: |
10.1146/annurev-pathmechdis-012419-032647 |
| PMID: |
33276706 |
| قاعدة البيانات: |
MEDLINE |
