دورية أكاديمية
أعرض في EDS

MITF functions as a tumor suppressor in non-small cell lung cancer beyond the canonically oncogenic role.

التفاصيل البيبلوغرافية
العنوان: MITF functions as a tumor suppressor in non-small cell lung cancer beyond the canonically oncogenic role.
المؤلفون: Hsiao YJ; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan., Chang WH; Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan., Chen HY; Institute of Statistical Science, Academia Sinica, Taipei, Taiwan., Hsu YC; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan., Chiu SC; Inservice Master Program in Life Sciences, College of Life Sciences, National Chung-Hsing University, Taichung, Taiwan., Chiang CC; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan., Chang GC; Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan., Chen YJ; Institute of Chemistry, Academia Sinica, Taipei, Taiwan., Wang CY; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan., Chen YM; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan., Lin CY; Institute of Statistical Science, Academia Sinica, Taipei, Taiwan., Chen YJ; Institute of Chemistry, Academia Sinica, Taipei, Taiwan., Yang PC; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan., Chen JJW; Institute of Biomedical Sciences, National Chung-Hsing University, Taichung, Taiwan., Yu SL; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan.; Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Centers for Genomic and Precision Medicine, National Taiwan University, Taipei, Taiwan.
المصدر: Aging [Aging (Albany NY)] 2020 Dec 03; Vol. 13 (1), pp. 646-674. Date of Electronic Publication: 2020 Dec 03.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Impact Journals, LLC Country of Publication: United States NLM ID: 101508617 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1945-4589 (Electronic) Linking ISSN: 19454589 NLM ISO Abbreviation: Aging (Albany NY) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Albany, NY : Impact Journals, LLC
مواضيع طبية MeSH: Adenocarcinoma of Lung/*genetics , Lung Neoplasms/*genetics , Microphthalmia-Associated Transcription Factor/*genetics, Adenocarcinoma of Lung/blood supply ; Adenocarcinoma of Lung/pathology ; Aged ; Alcohol Oxidoreductases/genetics ; Animals ; Annexin A1/genetics ; Carcinogenesis ; Carcinoma, Non-Small-Cell Lung/blood supply ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/pathology ; Cell Line, Tumor ; Cell Movement ; Female ; Frizzled Receptors/genetics ; Gene Knockdown Techniques ; Genes, Tumor Suppressor ; Humans ; Lung Neoplasms/blood supply ; Lung Neoplasms/pathology ; Male ; Mice ; Middle Aged ; Neoplasm Metastasis ; Neoplasm Transplantation ; Neovascularization, Pathologic ; Tumor Stem Cell Assay ; Exome Sequencing ; Wnt Signaling Pathway
مستخلص: Microphthalamia-associated transcription factor (MITF) is a critical mediator in melanocyte differentiation and exerts oncogenic functions in melanoma progression. However, the role of MITF in non-small cell lung cancer (NSCLC) is still unknown. We found that MITF is dominantly expressed in the low-invasive CL1-0 lung adenocarcinoma cells and paired adjacent normal lung tissues. MITF expression is significantly associated with better overall survival and disease-free survival in NSCLC and serves as an independent prognostic marker. Silencing MITF promotes tumor cell migration, invasion and colony formation in lung adenocarcinoma cells. In xenograft mouse model, MITF knockdown enhances metastasis and tumorigenesis, but decreases angiogenesis in the Matrigel plug assay. Whole transcriptome profiling of the landscape of MITF regulation in lung adenocarcinoma indicates that MITF is involved in cell development, cell cycle, inflammation and WNT signaling pathways. Chromatin immunoprecipitation assays revealed that MITF targets the promoters of FZD7 , PTGR1 and ANXA1 . Moreover, silencing FZD7 reduces the invasiveness that is promoted by silencing MITF. Strikingly, MITF has significantly inverse correlations with the expression of its downstream genes in lung adenocarcinoma. In summary, we demonstrate the suppressive role of MITF in lung cancer progression, which is opposite to the canonical oncogenic function of MITF in melanoma.
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فهرسة مساهمة: Keywords: FZD7; WNT pathway; metastasis; transcriptome profiling
المشرفين على المادة: 0 (ANXA1 protein, human)
0 (Annexin A1)
0 (FZD7 protein, human)
0 (Frizzled Receptors)
0 (MITF protein, human)
0 (Microphthalmia-Associated Transcription Factor)
EC 1.1.- (Alcohol Oxidoreductases)
EC 1.1.1.- (leukotriene B4 12-hydroxydehydrogenase)
تواريخ الأحداث: Date Created: 20201209 Date Completed: 20210507 Latest Revision: 20221207
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC7835003
DOI: 10.18632/aging.202171
PMID: 33293474
قاعدة البيانات: MEDLINE
الوصف
تدمد:1945-4589
DOI:10.18632/aging.202171