دورية أكاديمية
Development and validation of analytical method for identification of new psychoactive substances using linear retention indexes and gas chromatography-mass spectrometry.
| العنوان: | Development and validation of analytical method for identification of new psychoactive substances using linear retention indexes and gas chromatography-mass spectrometry. |
|---|---|
| المؤلفون: | Zacca JJ; National Institute of Criminalistics - Brazilian Federal Police (INC/PF) - SPO Lote 7 - Setores Complementares - Brasília/DF - 70.610-902, Brazil. Electronic address: zacca.jjz@pf.gov.br., Giudice GH; Brazilian Health Regulatory Agency (ANVISA) SIA - Trecho 5 - Área Especial 57 - Bloco D - 71.205.050 - Brasília/DF, Brazil; Institute of Chemistry, University of Brasília (IQ/UnB), P.O. Box 4478, 70904-970 Brasília, Distrito Federal, Brazil., Souza MP; National Institute of Criminalistics - Brazilian Federal Police (INC/PF) - SPO Lote 7 - Setores Complementares - Brasília/DF - 70.610-902, Brazil. Electronic address: monica.mps@pf.gov.br., Caldas LNB; National Institute of Criminalistics - Brazilian Federal Police (INC/PF) - SPO Lote 7 - Setores Complementares - Brasília/DF - 70.610-902, Brazil. Electronic address: luiza.lnbc@pf.gov.br., Vieira ML; National Institute of Criminalistics - Brazilian Federal Police (INC/PF) - SPO Lote 7 - Setores Complementares - Brasília/DF - 70.610-902, Brazil. Electronic address: mauricio.mlv@pf.gov.br., Machado AHL; Institute of Chemistry, University of Brasília (IQ/UnB), P.O. Box 4478, 70904-970 Brasília, Distrito Federal, Brazil. |
| المصدر: | Journal of chromatography. A [J Chromatogr A] 2021 Jan 11; Vol. 1636, pp. 461783. Date of Electronic Publication: 2020 Dec 06. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9318488 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3778 (Electronic) Linking ISSN: 00219673 NLM ISO Abbreviation: J Chromatogr A Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam ; New York : Elsevier, 1993- |
| مواضيع طبية MeSH: | Gas Chromatography-Mass Spectrometry/*methods , Psychotropic Drugs/*analysis, Analgesics, Opioid/analysis ; Cannabinoids/analysis ; Humans ; Models, Theoretical ; Phenethylamines/analysis ; Reproducibility of Results |
| مستخلص: | New Psychoactive Substances (NPS) are quickly developing to evade legislation, posing unprecedented challenges to public health and law enforcement authorities around the world. The aim of this work was to develop and validate a simple and reliable non-target gas chromatography/mass spectrometry (GC/MS) analytical method based on linear retention indexes for the expeditious identification of NPS without the need of analytical standards. The method was optimized and validated for 22 different drugs covering ten categories: phenethylamines (amphetamine, MDMA, methamphetamine, 25CNBOMe, 2-FA, 5-MAPB), "classic" drugs (cocaine, ephedrine, THC, heroine), synthetic cannabinoids (JWH-081, AM-2201, JWH-210, MAM-2201), piperazines (o-CPP, p-CPP), tryptamines (5-MeO-MiPT), synthetic cathinones (N-ethylpentylone), synthetic opioids (U-47700), aminoindanes (5-IAI), plant-based substances (Salvinorin-A) and "other" (methiopropamine). Three figures of merit (Selectivity, Precision and Robustness) were evaluated with retention index confidence intervals ranging from 0.5 to 20.6 i.u. and relative standard deviations in the range of 0.003% to 0.027% (repeatability) and 0.02% to 0.29% (intermediate precision). A general equation for estimating linear retention index variation as a function of retention time tolerance has been derived. This result in combination with a 2 Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2020. Published by Elsevier B.V.) |
| فهرسة مساهمة: | Keywords: GC/MS; Linear retention index; Method validation; New psychoactive substances; Retention index variation |
| المشرفين على المادة: | 0 (Analgesics, Opioid) 0 (Cannabinoids) 0 (Phenethylamines) 0 (Psychotropic Drugs) |
| تواريخ الأحداث: | Date Created: 20201219 Date Completed: 20210126 Latest Revision: 20210126 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.chroma.2020.461783 |
| PMID: | 33340744 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-3778 |
|---|---|
| DOI: | 10.1016/j.chroma.2020.461783 |