دورية أكاديمية
Beyond the joints, the extra-articular manifestations in rheumatoid arthritis.
| العنوان: | Beyond the joints, the extra-articular manifestations in rheumatoid arthritis. |
|---|---|
| المؤلفون: | Conforti A; Rheumatology, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy., Di Cola I; Rheumatology, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy., Pavlych V; Rheumatology, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy., Ruscitti P; Rheumatology, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy. Electronic address: piero.ruscitti@univaq.it., Berardicurti O; Rheumatology, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy., Ursini F; IRRCS Istituto Ortopedico Rizzoli, Bologna, Italy; Department of Biomedical and Neuromotor Sciences, University of Bologna, Italy., Giacomelli R; Rheumatology, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy., Cipriani P; Rheumatology, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy. |
| المصدر: | Autoimmunity reviews [Autoimmun Rev] 2021 Feb; Vol. 20 (2), pp. 102735. Date of Electronic Publication: 2020 Dec 17. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101128967 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-0183 (Electronic) Linking ISSN: 15689972 NLM ISO Abbreviation: Autoimmun Rev Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam ; New York : Elsevier, c2002- |
| مواضيع طبية MeSH: | Arthritis, Rheumatoid*/complications , Arthritis, Rheumatoid*/diagnosis , Sjogren's Syndrome*, Humans ; Male ; Retrospective Studies ; Rheumatoid Factor |
| مستخلص: | Rheumatoid arthritis (RA) is an inflammatory disease typically affecting the joints, but the systemic inflammatory process may involve other tissues and organs. Many extra-articular manifestations are recognized, which are related to worse long outcomes. Rheumatoid nodules are the most common extra-articular feature, found in about 30% of patients. Secondary Sjögren's syndrome and pulmonary manifestations are observed in almost 10% of patients, also in the early disease. Active RA with high disease activity has been associated with an increased risk of such features. Male gender, smoking habit, severe joint disease, worse function, high pro-inflammatory markers levels, high titer of rheumatoid factor, and HLA-related shared epitope have been reported as clinical predictors of occurrence of these rheumatoid complications. In addition, there is a little evidence deriving from randomized controlled trials in this field, thus the therapeutic strategy is mainly empiric and based on small case series and retrospective studies. However, considering that these extra-articular manifestations are usually related to the more active and severe RA, an aggressive therapeutic strategy is usually employed in view of the poor outcomes of these patients. The extra-articular features of RA remain, despite the improvement of joint damage, a major diagnostic and therapeutic challenge, since these are associated with a poor prognosis and need to be early recognized and promptly managed. (Copyright © 2020 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Extra-articular manifestations; Precision medicine; Rheumatoid arthritis; Therapy |
| المشرفين على المادة: | 9009-79-4 (Rheumatoid Factor) |
| تواريخ الأحداث: | Date Created: 20201221 Date Completed: 20210215 Latest Revision: 20210215 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.autrev.2020.102735 |
| PMID: | 33346115 |
| قاعدة البيانات: | MEDLINE |
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