دورية أكاديمية
Gene Polymorphisms Involved in Folate Metabolism and DNA Methylation with the Risk of Head and Neck Cancer.
| العنوان: | Gene Polymorphisms Involved in Folate Metabolism and DNA Methylation with the Risk of Head and Neck Cancer. |
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| المؤلفون: | De Castro TB; São Jose do Rio Preto Medical School (FAMERP), Molecular Biology Department, Genetic and Molecular Biology Research Unit (UPGEM), São José do Rio Preto, Brazil., Rodrigues-Fleming GH; São Jose do Rio Preto Medical School (FAMERP), Molecular Biology Department, Genetic and Molecular Biology Research Unit (UPGEM), São José do Rio Preto, Brazil., Oliveira-Cucolo JG; São Jose do Rio Preto Medical School (FAMERP), Molecular Biology Department, Genetic and Molecular Biology Research Unit (UPGEM), São José do Rio Preto, Brazil., Silva JNGD; São Jose do Rio Preto Medical School (FAMERP), Molecular Biology Department, Genetic and Molecular Biology Research Unit (UPGEM), São José do Rio Preto, Brazil., Silva FP; São Jose do Rio Preto Medical School (FAMERP), Molecular Biology Department, Genetic and Molecular Biology Research Unit (UPGEM), São José do Rio Preto, Brazil., Raposo LS; São Jose do Rio Preto Medical School (FAMERP), Otorhinolaryngology and Head and Neck Surgery Department, São José do Rio Preto, Brazil., Maniglia JV; São Jose do Rio Preto Medical School (FAMERP), Otorhinolaryngology and Head and Neck Surgery Department, São José do Rio Preto, Brazil., Pavarino EC; São Jose do Rio Preto Medical School (FAMERP), Molecular Biology Department, Genetic and Molecular Biology Research Unit (UPGEM), São José do Rio Preto, Brazil., Batista Arantes LMR; São Jose do Rio Preto Medical School (FAMERP), Molecular Biology Department, Genetic and Molecular Biology Research Unit (UPGEM), São José do Rio Preto, Brazil., Galbiatti-Dias ALS; São Jose do Rio Preto Medical School (FAMERP), Molecular Biology Department, Genetic and Molecular Biology Research Unit (UPGEM), São José do Rio Preto, Brazil., Maria Goloni Bertollo E; São Jose do Rio Preto Medical School (FAMERP), Molecular Biology Department, Genetic and Molecular Biology Research Unit (UPGEM), São José do Rio Preto, Brazil. |
| المصدر: | Asian Pacific journal of cancer prevention : APJCP [Asian Pac J Cancer Prev] 2020 Dec 01; Vol. 21 (12), pp. 3751-3759. Date of Electronic Publication: 2020 Dec 01. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Asian Pacific Organization for Cancer Prevention Country of Publication: Thailand NLM ID: 101130625 Publication Model: Electronic Cited Medium: Internet ISSN: 2476-762X (Electronic) Linking ISSN: 15137368 NLM ISO Abbreviation: Asian Pac J Cancer Prev Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Bangkok : Asian Pacific Organization for Cancer Prevention, |
| مواضيع طبية MeSH: | DNA Methylation*, DNA (Cytosine-5-)-Methyltransferases/*genetics , Folic Acid/*metabolism , Head and Neck Neoplasms/*epidemiology , Tetrahydrofolate Dehydrogenase/*genetics , Thymidylate Synthase/*genetics, Biomarkers, Tumor/analysis ; Brazil/epidemiology ; Case-Control Studies ; Female ; Follow-Up Studies ; Gene Expression Regulation, Neoplastic ; Genetic Predisposition to Disease ; Head and Neck Neoplasms/genetics ; Head and Neck Neoplasms/pathology ; Humans ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Prognosis ; Promoter Regions, Genetic ; Risk Factors ; Survival Rate ; DNA Methyltransferase 3B |
| مستخلص: | Background: Folate is essential for DNA synthesis, repair, and methylation. Polymorphisms in genes associated with folate metabolism may alter these processes and, consequently, modulate cancer development. Aim: We aimed to assess DNMT3B -149C/T (rs2424913), DNMT3B -283T/C (rs6087990), DNMT3B -579G/T (rs2424909), DHFR 19-pb ins/del (rs70991108), SHMT1 1420C/T (rs1979277), and TYMS 28-bp tandem repeat (rs34743033) polymorphisms with risk of head and neck cancer. Methods: A case-control study was conducted in 1,086 Brazilian individuals. Real-time and conventional polymerase chain reactions-PCR were performed for genotyping the polymorphisms. Results: The single nucleotide polymorphism (SNP), DNMT3B -283T/C, revealed a higher risk of head and neck squamous cell carcinoma (HNSCC) when compared with the C group in the codominant (p < 0.001), dominant (p <0.001), and overdominant (p= 0.001) models for T/C and C/C genotypes. DNMT3B -149C/T and DNMT3B -579G/T revealed no association between groups in any model. The DHFR 19-pb ins/del polymorphism protected against HNSCC development compared to the C group by the codominant (p < 0.001), dominant (p < 0.001), and overdominant (p < 0.001) models. In the TYMS, the 3R/3R genotype had a protective effect against HNSCC development compared with the C group by the recessive models (p= 0.009). In contrast, SHMT1 1420 C/T presented no association between the HNSCC and C groups. DHFR 19-pb ins/del polymorphisms protected against oral cavity cancer (p= 0.003), and only TYMS-28 3R/3R decreased the risk of tumor progression (p= 0.023). In the Kaplan-Meier curve, an association was found between DHFR ins/ins and TYMS -28 3R carriers with respect to relapse-free time; further, DNMT3B -579 T and TYMS-28 2R/2R carriers had longer survival times. Conclusion: DNMT3B -283T/C is associated with higher risk, whereas DHFR 19-pb ins/del and TYMS 28 3R/3R protect against head and neck cancer. We also highlighted the association of TYMS 3R/3R genotype carriers with relapse-free cancer protection and survival time. |
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| فهرسة مساهمة: | Keywords: DNA Methylation; Folate; Polymorphism; head and neck cancer |
| المشرفين على المادة: | 0 (Biomarkers, Tumor) 935E97BOY8 (Folic Acid) EC 1.5.1.3 (Tetrahydrofolate Dehydrogenase) EC 2.1.1.37 (DNA (Cytosine-5-)-Methyltransferases) EC 2.1.1.45 (TYMS protein, human) EC 2.1.1.45 (Thymidylate Synthase) |
| تواريخ الأحداث: | Date Created: 20201228 Date Completed: 20210901 Latest Revision: 20231213 |
| رمز التحديث: | 20240829 |
| مُعرف محوري في PubMed: | PMC8046294 |
| DOI: | 10.31557/APJCP.2020.21.12.3751 |
| PMID: | 33369477 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2476-762X |
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| DOI: | 10.31557/APJCP.2020.21.12.3751 |