دورية أكاديمية
The prevalence of esophageal cancer after caustic and pesticide ingestion: A nationwide cohort study.
| العنوان: | The prevalence of esophageal cancer after caustic and pesticide ingestion: A nationwide cohort study. |
|---|---|
| المؤلفون: | Mu HW; Division of Toxicology, China Medical University Hospital, Taichung, Taiwan.; Department of Emergency Medicine, China Medical University Hospital, Taichung, Taiwan., Chen CH; Division of Toxicology, China Medical University Hospital, Taichung, Taiwan.; Department of Emergency Medicine, China Medical University Hospital, Taichung, Taiwan., Yang KW; Division of Toxicology, China Medical University Hospital, Taichung, Taiwan.; Department of Emergency Medicine, China Medical University Hospital, Taichung, Taiwan., Pan CS; Division of Toxicology, China Medical University Hospital, Taichung, Taiwan.; Department of Emergency Medicine, China Medical University Hospital, Taichung, Taiwan., Lin CL; Management Office of Health Data, China Medical University Hospital, Taichung, Taiwan., Hung DZ; Division of Toxicology, China Medical University Hospital, Taichung, Taiwan. |
| المصدر: | PloS one [PLoS One] 2020 Dec 29; Vol. 15 (12), pp. e0243922. Date of Electronic Publication: 2020 Dec 29 (Print Publication: 2020). |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: San Francisco, CA : Public Library of Science |
| مواضيع طبية MeSH: | Carcinoma/*epidemiology , Caustics/*poisoning , Esophageal Neoplasms/*epidemiology , Pesticides/*poisoning, Adult ; Aged ; Carcinoma/chemically induced ; Carcinoma/pathology ; Cohort Studies ; Detergents/poisoning ; Eating/drug effects ; Esophageal Neoplasms/chemically induced ; Esophageal Neoplasms/pathology ; Female ; Humans ; Male ; Middle Aged ; Proportional Hazards Models ; Risk Factors |
| مستخلص: | Habits such as smoking and alcohol drinking and existing esophageal malfunction are considered the main risk factors for esophageal carcinogenesis. Caustic ingestion of acidic or alkaline agents or strong irritants can induce severe esophageal corrosive injury and increase esophageal cancer risk. We studied the relationship between esophageal carcinoma and acute detergent or pesticide poisoning by using nationwide health insurance data. Methodology/Principle findings: We compared a pesticide/detergent intoxication cohort (N = 21,840) and an age- and gender-matched control cohort (N = 21,840) identified from the National Health Insurance Research Database between 2000 and 2011. We used the multivariable Cox proportional model to determine esophageal carcinoma risk. The overall incidence density of esophageal cancer was 1.66 per 10,000 person-years in the comparison cohort and 4.36 per 10,000 person-years in the pesticide/detergent intoxication cohort. The corresponding adjusted hazard ratio (HR) for esophageal cancer was 2.33 (95% confidence interval [CI] = 1.41-3.86) in the pesticide/detergent intoxication cohort compared with the control cohort. Patients with corrosive and detergent intoxication did not have a higher risk of esophageal cancer (adjusted HR = 0.98, 95% CI = 0.29-3.33) than those without pesticide/detergent intoxication. However, patients with pesticide intoxication had a significantly higher risk of esophageal cancer (adjusted HR = 2.52, 95% CI = 1.52-4.18) than those without pesticide/detergent intoxication. Conclusion: In the present study, after adjusting for conventional risk factors, we observed that pesticide intoxication could exert substantial effects through increased esophageal cancer risk. However, patients with detergent intoxication may not have an increased risk of esophageal cancer. Competing Interests: The authors have declared that no competing interests exist. |
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| المشرفين على المادة: | 0 (Caustics) 0 (Detergents) 0 (Pesticides) |
| تواريخ الأحداث: | Date Created: 20201229 Date Completed: 20210209 Latest Revision: 20210209 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC7771858 |
| DOI: | 10.1371/journal.pone.0243922 |
| PMID: | 33373373 |
| قاعدة البيانات: | MEDLINE |
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