دورية أكاديمية
أعرض في EDS

Role of Microgliosis and NLRP3 Inflammasome in Parkinson's Disease Pathogenesis and Therapy.

التفاصيل البيبلوغرافية
العنوان: Role of Microgliosis and NLRP3 Inflammasome in Parkinson's Disease Pathogenesis and Therapy.
المؤلفون: de Araújo FM; Clinical and Experimental Neuroscience (NiCE), Institute for Bio-Health Research of Murcia (IMIB), Institute for Aging Research (IUIE), School of Medicine, Campus Mare Nostrum, University of Murcia, Murcia, Spain.; Laboratory of Neurochemistry and Cell Biology, Department of Biochemistry and Biophysics, Institute of Health Sciences, Federal University of Bahia, Salvador, Bahia, 40110-100, Brazil., Cuenca-Bermejo L; Clinical and Experimental Neuroscience (NiCE), Institute for Bio-Health Research of Murcia (IMIB), Institute for Aging Research (IUIE), School of Medicine, Campus Mare Nostrum, University of Murcia, Murcia, Spain., Fernández-Villalba E; Clinical and Experimental Neuroscience (NiCE), Institute for Bio-Health Research of Murcia (IMIB), Institute for Aging Research (IUIE), School of Medicine, Campus Mare Nostrum, University of Murcia, Murcia, Spain., Costa SL; Laboratory of Neurochemistry and Cell Biology, Department of Biochemistry and Biophysics, Institute of Health Sciences, Federal University of Bahia, Salvador, Bahia, 40110-100, Brazil. costasl@ufba.br., Silva VDA; Laboratory of Neurochemistry and Cell Biology, Department of Biochemistry and Biophysics, Institute of Health Sciences, Federal University of Bahia, Salvador, Bahia, 40110-100, Brazil. vdsilva@ufba.br., Herrero MT; Clinical and Experimental Neuroscience (NiCE), Institute for Bio-Health Research of Murcia (IMIB), Institute for Aging Research (IUIE), School of Medicine, Campus Mare Nostrum, University of Murcia, Murcia, Spain. mtherrer@um.es.
المصدر: Cellular and molecular neurobiology [Cell Mol Neurobiol] 2022 Jul; Vol. 42 (5), pp. 1283-1300. Date of Electronic Publication: 2021 Jan 02.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 8200709 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-6830 (Electronic) Linking ISSN: 02724340 NLM ISO Abbreviation: Cell Mol Neurobiol Subsets: MEDLINE
أسماء مطبوعة: Publication: 1999- : New York : Kluwer Academic/Plenum Publishers
Original Publication: New York : Plenum Press, c1981-
مواضيع طبية MeSH: Inflammasomes* , Parkinson Disease*/pathology, Humans ; Inflammation/pathology ; Microglia/pathology ; NLR Family, Pyrin Domain-Containing 3 Protein
مستخلص: Parkinson's disease (PD) is a neurodegenerative disorder marked primarily by motor symptoms such as rigidity, bradykinesia, postural instability and resting tremor associated with dopaminergic neuronal loss in the Substantia Nigra pars compacta (SNpc) and deficit of dopamine in the basal ganglia. These motor symptoms can be preceded by pre-motor symptoms whose recognition can be useful to apply different strategies to evaluate risk, early diagnosis and prevention of PD progression. Although clinical characteristics of PD are well defined, its pathogenesis is still not completely known, what makes discoveries of therapies capable of curing patients difficult to be reached. Several theories about the cause of idiopathic PD have been investigated and among them, the key role of inflammation, microglia and the inflammasome in the pathogenesis of PD has been considered. In this review, we describe the role and relation of both the inflammasome and microglial activation with the pathogenesis, symptoms, progression and the possibilities for new therapeutic strategies in PD.
(© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature.)
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معلومات مُعتمدة: PDSE -47/2017 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; FPU 18/02549 Ministerio de Ciencia, Innovación y Universidades; FIS PI13 01293 Federación Española de Parkinson; 19540/PI/14 Fundación Séneca; JCB0057/2016 Fundação de Amparo à Pesquisa do Estado da Bahia; 429127/2018-9 Conselho Nacional de Desenvolvimento Científico e Tecnológico; Research Fellowship Conselho Nacional de Desenvolvimento Científico e Tecnológico
فهرسة مساهمة: Keywords: Glial cell; Inflammasome; Microglia; Neuroinflammation; Parkinson’s disease
المشرفين على المادة: 0 (Inflammasomes)
0 (NLR Family, Pyrin Domain-Containing 3 Protein)
تواريخ الأحداث: Date Created: 20210102 Date Completed: 20220531 Latest Revision: 20220531
رمز التحديث: 20231215
DOI: 10.1007/s10571-020-01027-6
PMID: 33387119
قاعدة البيانات: MEDLINE
الوصف
تدمد:1573-6830
DOI:10.1007/s10571-020-01027-6