دورية أكاديمية
أعرض في EDS

Heart rate kinetics during standard cardiopulmonary exercise testing in heart transplant recipients: a longitudinal study.

التفاصيل البيبلوغرافية
العنوان: Heart rate kinetics during standard cardiopulmonary exercise testing in heart transplant recipients: a longitudinal study.
المؤلفون: Schumacher O; Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Exercise Physiology Lab, Institute of Human Movement Sciences and Sport, ETH Zurich, Zurich, Switzerland., Trachsel LD; Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Herzig D; Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Mohacsi P; Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Sigurdardottir V; Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Wilhelm M; Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Eser P; Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
المصدر: ESC heart failure [ESC Heart Fail] 2021 Apr; Vol. 8 (2), pp. 1096-1105. Date of Electronic Publication: 2021 Jan 08.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: John Wiley & Sons Ltd on behalf of the European Society of Cardiology Country of Publication: England NLM ID: 101669191 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2055-5822 (Electronic) Linking ISSN: 20555822 NLM ISO Abbreviation: ESC Heart Fail Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Oxford] : John Wiley & Sons Ltd on behalf of the European Society of Cardiology, [2014]-
مواضيع طبية MeSH: Exercise Test* , Heart Transplantation*, Heart Rate ; Humans ; Kinetics ; Longitudinal Studies ; Tissue Donors
مستخلص: Aims: Heart transplantation (HTx) results in complete autonomic denervation of the donor heart, causing resting tachycardia and abnormal heart rate (HR) responses to exercise. We determined the time course of suggestive cardiac reinnervation post HTx and investigated its clinical significance.
Methods and Results: Heart rate kinetics during standard cardiopulmonary exercise testing at 2.5-5 years after HTx was assessed in 58 patients. According to their HR increase 30 s after exercise onset, HTx recipients were classified as denervated (slow responders: <5 beats per minute [b.p.m.]) or potentially reinnervated (fast responders: ≥5 b.p.m.). Additionally, in 30 patients, longitudinal changes of maximal oxygen consumption and HR kinetics were assessed during the first 15 post-operative years. At 2.5-5 years post HTx, 38% of our study population was potentially reinnervated. Fast responders were significantly younger (41 ± 15 years) than slow responders (53 ± 13 years, P = 0.003) but did not differ with regard to donor age, immunosuppressive regime, cardiovascular risk factors, endomyocardial biopsy, or vasculopathy parameters. While HR reserve (56 ± 20 vs. 39 ± 15 b.p.m., P = 0.002) and HR recovery after 60 s (15 ± 11 vs. 5 ± 6 b.p.m., P < 0.001) were greater in fast responders, resting HR, peak HR of predicted, and peak oxygen consumption of predicted were comparable.
Conclusions: Signs of reinnervation occurred mainly in younger patients. Maximal oxygen consumption was independent of HR kinetics.
(© 2021 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of the European Society of Cardiology.)
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فهرسة مساهمة: Keywords: Exercise capacity; Exercise testing; Heart rate; Heart rate recovery; Heart transplantation; Reinnervation
تواريخ الأحداث: Date Created: 20210108 Date Completed: 20210701 Latest Revision: 20231111
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC8006603
DOI: 10.1002/ehf2.13102
PMID: 33417294
قاعدة البيانات: MEDLINE
الوصف
تدمد:2055-5822
DOI:10.1002/ehf2.13102