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Neuroprotection elicited by resveratrol in a rat model of hypothyroidism: Possible involvement of cholinergic signaling and redox status.

التفاصيل البيبلوغرافية
العنوان: Neuroprotection elicited by resveratrol in a rat model of hypothyroidism: Possible involvement of cholinergic signaling and redox status.
المؤلفون: de Souza Cardoso J; Laboratório de Biomarcadores, Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Campus Universitário Capão do Leão s/n, Pelotas, RS, Brazil., Baldissarelli J; Departamento de Fisiologia e Farmacologia, Instituto de Biologia, Universidade Federal de Pelotas, Campus Universitário Capão do Leão, Pelotas, RS, Brazil., Reichert KP; Programa de Pós-graduação em Ciências Biológicas: Bioquímica Toxicológica, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil., Teixeira FC; Laboratório de Neuroquímica, Inflamação e Câncer, Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Campus Universitário Capão do Leão, Pelotas, RS, Brazil., Pereira Soares MS; Laboratório de Neuroquímica, Inflamação e Câncer, Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Campus Universitário Capão do Leão, Pelotas, RS, Brazil., Chitolina Schetinger MR; Programa de Pós-graduação em Ciências Biológicas: Bioquímica Toxicológica, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil., Morsch VM; Programa de Pós-graduação em Ciências Biológicas: Bioquímica Toxicológica, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil., Farias Martins Filho AO; Faculdade de Nutrição, Universidade Federal de Pelotas, Pelotas, RS, Brazil., Duarte Junior HR; Faculdade de Nutrição, Universidade Federal de Pelotas, Pelotas, RS, Brazil., Ribeiro Coriolano FH; Faculdade de Nutrição, Universidade Federal de Pelotas, Pelotas, RS, Brazil., Spanevello RM; Laboratório de Neuroquímica, Inflamação e Câncer, Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Campus Universitário Capão do Leão, Pelotas, RS, Brazil., Stefanello FM; Laboratório de Biomarcadores, Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Campus Universitário Capão do Leão s/n, Pelotas, RS, Brazil. Electronic address: francieli.stefanelo@ufpel.edu.br., Tavares RG; Laboratório de Biomarcadores, Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Campus Universitário Capão do Leão s/n, Pelotas, RS, Brazil; CBIOS- Universidade Lusófona de Lisboa, Lisboa, Portugal.
المصدر: Molecular and cellular endocrinology [Mol Cell Endocrinol] 2021 Mar 15; Vol. 524, pp. 111157. Date of Electronic Publication: 2021 Jan 07.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: North Holland Publishing Country of Publication: Ireland NLM ID: 7500844 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8057 (Electronic) Linking ISSN: 03037207 NLM ISO Abbreviation: Mol Cell Endocrinol Subsets: MEDLINE
أسماء مطبوعة: Publication: Limerick : North Holland Publishing
Original Publication: Amsterdam, North-Holland.
مواضيع طبية MeSH: Signal Transduction*/drug effects, Cholinergic Agents/*metabolism , Hypothyroidism/*metabolism , Hypothyroidism/*pathology , Neuroprotection/*drug effects , Resveratrol/*pharmacology, Acetylcholinesterase/metabolism ; Animals ; Antigens, Nuclear/metabolism ; Disease Models, Animal ; Glial Fibrillary Acidic Protein/metabolism ; Hippocampus/metabolism ; Hypothyroidism/blood ; Male ; Nerve Tissue Proteins/metabolism ; Oxidation-Reduction/drug effects ; Oxidative Stress/drug effects ; Rats, Wistar ; Receptors, Cholinergic/metabolism ; Thyroxine/blood ; Triiodothyronine/blood ; Rats
مستخلص: Both the cholinergic pathway and oxidative stress are important mechanisms involved in the pathogenesis of hypothyroidism, a condition characterized by low levels of thyroid hormone that predispose the patient to brain dysfunction. Phenolic compounds have numerous health benefits, including antioxidant activity. This study evaluates the preventive effects of resveratrol in the cholinergic system and redox status in rats with methimazole-induced hypothyroidism. Hypothyroidism increases acetylcholinesterase (AChE) activity and density in the cerebral cortex and hippocampus and decreases the α7 and M1 receptor densities in the hippocampus. Hypothyroidism also increases cellular levels of reactive oxygen species (ROS) and thiobarbituric acid reactive substances (TBARS), but reduces total thiol content, and catalase and superoxide dismutase activities in the serum. In the cerebral cortex and hippocampus, hypothyroidism increases the levels of ROS and nitrites. In this study, resveratrol (50 mg/kg) treatment prevents the observed increase in AChE in the cerebral cortex, and increases the protein levels of NeuN, a marker of mature neurons. Resveratrol also prevents changes in serum ROS levels and brain structure, as well as the levels of TBARS, total thiol content, and serum catalase enzyme activity. These collective findings suggest that resveratrol has a high antioxidant capacity and can restore hypothyroidism-triggered alterations related to neurotransmission. Thus, it is a promising agent for the prevention of brain damage resulting from hypothyroidism.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Cholinergic signaling; Hypothyroidism; Oxidative stress; Phenolic compound; Resveratrol
المشرفين على المادة: 0 (Antigens, Nuclear)
0 (Cholinergic Agents)
0 (Glial Fibrillary Acidic Protein)
0 (Nerve Tissue Proteins)
0 (Rbfox3 protein, rat)
0 (Receptors, Cholinergic)
06LU7C9H1V (Triiodothyronine)
EC 3.1.1.7 (Acetylcholinesterase)
Q369O8926L (Resveratrol)
Q51BO43MG4 (Thyroxine)
تواريخ الأحداث: Date Created: 20210109 Date Completed: 20210923 Latest Revision: 20240226
رمز التحديث: 20240226
DOI: 10.1016/j.mce.2021.111157
PMID: 33421531
قاعدة البيانات: MEDLINE
الوصف
تدمد:1872-8057
DOI:10.1016/j.mce.2021.111157