دورية أكاديمية
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Fungus Metarhizium robertsii and neurotoxic insecticide affect gut immunity and microbiota in Colorado potato beetles.

التفاصيل البيبلوغرافية
العنوان: Fungus Metarhizium robertsii and neurotoxic insecticide affect gut immunity and microbiota in Colorado potato beetles.
المؤلفون: Kryukov VY; Institute of Systematics and Ecology of Animals, Siberian Branch of Russian Academy of Sciences, Novosibirsk, 630091, Russia. krukoff@mail.ru.; Tomsk State University, Tomsk, 634050, Russia. krukoff@mail.ru., Rotskaya U; Institute of Systematics and Ecology of Animals, Siberian Branch of Russian Academy of Sciences, Novosibirsk, 630091, Russia., Yaroslavtseva O; Institute of Systematics and Ecology of Animals, Siberian Branch of Russian Academy of Sciences, Novosibirsk, 630091, Russia., Polenogova O; Institute of Systematics and Ecology of Animals, Siberian Branch of Russian Academy of Sciences, Novosibirsk, 630091, Russia., Kryukova N; Institute of Systematics and Ecology of Animals, Siberian Branch of Russian Academy of Sciences, Novosibirsk, 630091, Russia., Akhanaev Y; Institute of Systematics and Ecology of Animals, Siberian Branch of Russian Academy of Sciences, Novosibirsk, 630091, Russia., Krivopalov A; Institute of Systematics and Ecology of Animals, Siberian Branch of Russian Academy of Sciences, Novosibirsk, 630091, Russia., Alikina T; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Sciences, Novosibirsk, 630090, Russia., Vorontsova YL; Institute of Systematics and Ecology of Animals, Siberian Branch of Russian Academy of Sciences, Novosibirsk, 630091, Russia., Slepneva I; Voevodsky Institute of Chemical Kinetics and Combustion, Siberian Branch of Russian Academy of Sciences, Novosibirsk, 630090, Russia., Kabilov M; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Sciences, Novosibirsk, 630090, Russia., Glupov VV; Institute of Systematics and Ecology of Animals, Siberian Branch of Russian Academy of Sciences, Novosibirsk, 630091, Russia.
المصدر: Scientific reports [Sci Rep] 2021 Jan 14; Vol. 11 (1), pp. 1299. Date of Electronic Publication: 2021 Jan 14.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Coleoptera/*immunology , Insecticides/*pharmacology , Intestines/*immunology , Ivermectin/*analogs & derivatives , Metarhizium/*immunology , Signal Transduction/*drug effects, Animals ; Ivermectin/pharmacology ; Signal Transduction/immunology
مستخلص: Fungal infections and toxicoses caused by insecticides may alter microbial communities and immune responses in the insect gut. We investigated the effects of Metarhizium robertsii fungus and avermectins on the midgut physiology of Colorado potato beetle larvae. We analyzed changes in the bacterial community, immunity- and stress-related gene expression, reactive oxygen species (ROS) production, and detoxification enzyme activity in response to topical infection with the M. robertsii fungus, oral administration of avermectins, and a combination of the two treatments. Avermectin treatment led to a reduction in microbiota diversity and an enhancement in the abundance of enterobacteria, and these changes were followed by the downregulation of Stat and Hsp90, upregulation of transcription factors for the Toll and IMD pathways and activation of detoxification enzymes. Fungal infection also led to a decrease in microbiota diversity, although the changes in community structure were not significant, except for the enhancement of Serratia. Fungal infection decreased the production of ROS but did not affect the gene expression of the immune pathways. In the combined treatment, fungal infection inhibited the activation of detoxification enzymes and prevented the downregulation of the JAK-STAT pathway caused by avermectins. The results of this study suggest that fungal infection modulates physiological responses to avermectins and that fungal infection may increase avermectin toxicosis by blocking detoxification enzymes in the gut.
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المشرفين على المادة: 0 (Insecticides)
70288-86-7 (Ivermectin)
73989-17-0 (avermectin)
SCR Organism: Metarhizium robertsii
تواريخ الأحداث: Date Created: 20210115 Date Completed: 20210811 Latest Revision: 20210811
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC7809261
DOI: 10.1038/s41598-020-80565-x
PMID: 33446848
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-020-80565-x