دورية أكاديمية
Body composition, physical function and quality of life in healthy men and across different stages of prostate cancer.
| العنوان: | Body composition, physical function and quality of life in healthy men and across different stages of prostate cancer. |
|---|---|
| المؤلفون: | Hanson ED; Department of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. edhanson@email.unc.edu.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. edhanson@email.unc.edu.; Institute of Health and Sport, Victoria University, Melbourne, VIC, Australia. edhanson@email.unc.edu., Stopforth CK; Department of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Alzer M; Department of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Carver J; Department of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Lucas AR; Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, NC, USA.; Virginia Commonwealth University, Richmond, VA, USA., Whang YE; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Division of Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Milowsky MI; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Division of Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Bartlett DB; Division of Medical Oncology, Duke Cancer Institute, Duke University, Durham, NC, USA., Harrison MR; Division of Medical Oncology, Duke Cancer Institute, Duke University, Durham, NC, USA., Hayes A; Institute of Health and Sport, Victoria University, Melbourne, VIC, Australia.; Australian Institute for Musculoskeletal Science, Victoria University, Melbourne, VIC, Australia., Bitting RL; Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, NC, USA., Deal AM; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Hackney AC; Department of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Nutrition, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Battaglini CL; Department of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. |
| المصدر: | Prostate cancer and prostatic diseases [Prostate Cancer Prostatic Dis] 2021 Sep; Vol. 24 (3), pp. 725-732. Date of Electronic Publication: 2021 Jan 25. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9815755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5608 (Electronic) Linking ISSN: 13657852 NLM ISO Abbreviation: Prostate Cancer Prostatic Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2002->: London : Nature Publishing Group Original Publication: Houndmills, Basingstoke, UK : Stockton Press, c1997- |
| مواضيع طبية MeSH: | Body Composition* , Exercise* , Quality of Life* , Walking*, Androgen Antagonists/*therapeutic use , Neoplasms, Hormone-Dependent/*pathology , Prostatic Neoplasms/*pathology, Aged ; Case-Control Studies ; Cross-Sectional Studies ; Follow-Up Studies ; Humans ; Male ; Neoplasms, Hormone-Dependent/drug therapy ; Neoplasms, Hormone-Dependent/psychology ; Prognosis ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/psychology |
| مستخلص: | Background: Androgen deprivation therapy (ADT) for prostate cancer (PC) has detrimental effects on physical function and quality of life (QoL), but the addition of androgen receptor signalling inhibitors (ARSI) on these outcomes is unclear. Purpose: To compare body composition, physical function, and QoL across progressive stages of PC and non-cancer controls (CON). Methods: In men with hormone sensitive PC (HSPC, n = 43) or metastatic castration-resistant PC (mCRPC, n = 22) or CON (n = 37), relative and absolute lean and fat mass, physical function (6 m walk, chair stands, timed up and go [TUG], stair climb), and QoL were determined. Results: Relative body composition differed amongst all groups, along with ~39% greater absolute fat mass in mCRPC vs. CON. TUG and chair stands were ~71% and ~33% slower in mCRPC compared to both CON and HSPC, whereas stair climb was ~29% and 6 m walk was ~18% slower in mCRPC vs. CON. Relative body composition was correlated with physical function (r = 0.259-0.385). Clinically relevant differences for mCRPC were observed for overall QoL and several subscales vs. CON, although body composition and physical function did not influence QoL. Conclusions: PC progression is associated with deteriorations in body composition and physical function. As ADT length was similar between groups, ARSI use for mCRPC likely contributed in part to these changes. Given the difficulties of improving lean mass during ADT, interventions that reduce adiposity may lessen the side effects of hormone therapy. (© 2021. The Author(s), under exclusive licence to Springer Nature Limited part of Springer Nature.) |
| References: | Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020. CA Cancer J Clin. 2020;70:7–30. (PMID: 3191290210.3322/caac.21590) Sharifi N, Gulley JL, Dahut WL. Androgen deprivation therapy for prostate cancer. JAMA. 2005;294:238–44. (PMID: 1601459810.1001/jama.294.2.238) Galvao DA, Spry NA, Taaffe DR, Newton RU, Stanley J, Shannon T, et al. Changes in muscle, fat and bone mass after 36 weeks of maximal androgen blockade for prostate cancer. BJU Int. 2008;102:44–7. (PMID: 1833660610.1111/j.1464-410X.2008.07539.x) Greenspan SL, Coates P, Sereika SM, Nelson JB, Trump DL, Resnick NM. Bone loss after initiation of androgen deprivation therapy in patients with prostate cancer. J Clin Endocrinol Metab. 2005;90:6410–7. (PMID: 1618926110.1210/jc.2005-0183) Levy ME, Perera S, van Londen GJ, Nelson JB, Clay CA, Greenspan SL. Physical function changes in prostate cancer patients on androgen deprivation therapy: a 2-year prospective study. Urology. 2008;71:735–9. (PMID: 1827993310.1016/j.urology.2007.09.018) Smith MR, Saad F, Egerdie B, Sieber PR, Tammela TL, Ke C, et al. Sarcopenia during androgen-deprivation therapy for prostate cancer. J Clin Oncol. 2012;30:3271–6. (PMID: 22649143343498710.1200/JCO.2011.38.8850) van Londen GJ, Levy ME, Perera S, Nelson JB, Greenspan SL. Body composition changes during androgen deprivation therapy for prostate cancer: a 2-year prospective study. Crit Rev Oncol Hematol. 2008;68:172–7. (PMID: 18706829282616310.1016/j.critrevonc.2008.06.006) Clay CA, Perera S, Wagner JM, Miller ME, Nelson JB, Greenspan SL. Physical function in men with prostate cancer on androgen deprivation therapy. Phys Ther. 2007;87:1325–33. (PMID: 1768408410.2522/ptj.20060302) Galvao DA, Taaffe DR, Spry N, Joseph D, Turner D, Newton RU. Reduced muscle strength and functional performance in men with prostate cancer undergoing androgen suppression: a comprehensive cross-sectional investigation. Prostate Cancer Prostatic Dis. 2009;12:198–203. (PMID: 1885270310.1038/pcan.2008.51) Gonzalez BD, Jim HSL, Small BJ, Sutton SK, Fishman MN, Zachariah B, et al. Changes in physical functioning and muscle strength in men receiving androgen deprivation therapy for prostate cancer: a controlled comparison. Support Care Cancer. 2016;24:2201–7. (PMID: 2656318310.1007/s00520-015-3016-y) Joly F, Alibhai SM, Galica J, Park A, Yi QL, Wagner L, et al. Impact of androgen deprivation therapy on physical and cognitive function, as well as quality of life of patients with nonmetastatic prostate cancer. J Urol. 2006;176:2443–7. (PMID: 1708512510.1016/j.juro.2006.07.151) Chi KN, Protheroe A, Rodriguez-Antolin A, Facchini G, Suttman H, Matsubara N, et al. Patient-reported outcomes following abiraterone acetate plus prednisone added to androgen deprivation therapy in patients with newly diagnosed metastatic castration-naive prostate cancer (LATITUDE): an international, randomised phase 3 trial. Lancet Oncol. 2018;19:194–206. (PMID: 2932603010.1016/S1470-2045(17)30911-7) Dacal K, Sereika SM, Greenspan SL. Quality of life in prostate cancer patients taking androgen deprivation therapy. J Am Geriatr Soc. 2006;54:85–90. (PMID: 1642020210.1111/j.1532-5415.2005.00567.x) Gagliano-Juca T, Travison TG, Nguyen PL, Kantoff PW, Taplin ME, Kibel AS, et al. Effects of androgen deprivation therapy on pain perception, quality of life, and depression in men with prostate cancer. J Pain Symptom Manag. 2018;55:307–17 e1. (PMID: 10.1016/j.jpainsymman.2017.09.017) Karantanos T, Corn PG, Thompson TC. Prostate cancer progression after androgen deprivation therapy: mechanisms of castrate resistance and novel therapeutic approaches. Oncogene. 2013;32:5501–11. (PMID: 23752182390887010.1038/onc.2013.206) Jin JK, Dayyani F, Gallick GE. Steps in prostate cancer progression that lead to bone metastasis. Int J Cancer. 2011;128:2545–61. (PMID: 21365645308228410.1002/ijc.26024) Crawford ED, Higano CS, Shore ND, Hussain M, Petrylak DP. Treating patients with metastatic castration resistant prostate cancer: a comprehensive review of available therapies. J Urol. 2015;194:1537–47. (PMID: 2619673510.1016/j.juro.2015.06.106) Beer TM, Armstrong AJ, Rathkopf D, Loriot Y, Sternberg CN, Higano CS, et al. Enzalutamide in men with chemotherapy-naive metastatic castration-resistant prostate cancer: extended analysis of the phase 3 PREVAIL study. Eur Urol. 2017;71:151–4. (PMID: 2747752510.1016/j.eururo.2016.07.032) de Bono JS, Logothetis CJ, Molina A, Fizazi K, North S, Chu L, et al. Abiraterone and increased survival in metastatic prostate cancer. N Engl J Med. 2011;364:1995–2005. (PMID: 21612468347114910.1056/NEJMoa1014618) Pezaro C, Mukherji D, Tunariu N, Cassidy AM, Omlin A, Bianchini D, et al. Sarcopenia and change in body composition following maximal androgen suppression with abiraterone in men with castration-resistant prostate cancer. Br J Cancer. 2013;109:325–31. (PMID: 23807167372139710.1038/bjc.2013.340) Chowdhury S, Oudard S, Uemura H, Joniau S, Pilon D, Lefebvre P, et al. Matching-adjusted indirect comparison of health-related quality of life and adverse events of apalutamide versus enzalutamide in non-metastatic castration-resistant prostate cancer. Adv Ther. 2020;37:512–26. (PMID: 3181308710.1007/s12325-019-01157-4) Ning YM, Brave M, Maher VE, Zhang L, Tang S, Sridhara R, et al. U.S. Food and Drug Administration Approval summary: enzalutamide for the treatment of patients with chemotherapy-naive metastatic castration-resistant prostate cancer. Oncologist. 2015;20:960–6. (PMID: 26070917452476010.1634/theoncologist.2015-0166) Khalaf DJ, Sunderland K, Eigl BJ, Kollmannsberger CK, Ivanov N, Finch DL, et al. Health-related quality of life for abiraterone plus prednisone versus enzalutamide in patients with metastatic castration-resistant prostate cancer: results from a phase II randomized trial. Eur Urol. 2019;75:940–7. (PMID: 3059135410.1016/j.eururo.2018.12.015) Campbell KL, Winters-Stone KM, Wiskemann J, May AM, Schwartz AL, Courneya KS, et al. Exercise guidelines for cancer survivors: consensus statement from international multidisciplinary roundtable. Med Sci Sports Exerc. 2019;51:2375–90. (PMID: 3162605510.1249/MSS.00000000000021168576825) Hayes SC, Newton RU, Spence RR, Galvao DA. The Exercise and Sports Science Australia position statement: exercise medicine in cancer management. J Sci Med Sport. 2019;22:1175–99. (PMID: 3127792110.1016/j.jsams.2019.05.003) Hanson ED, Sakkal S, Evans WS, Violet JA, Battaglini CL, McConell GK, et al. Altered stress hormone response following acute exercise during prostate cancer treatment. Scand J Med Sci Sports. 2018;28:1925–33. (PMID: 2966808210.1111/sms.13199) Hanson ED, Sheaff AK, Sood S, Ma L, Francis JD, Goldberg AP, et al. Strength training induces muscle hypertrophy and functional gains in black prostate cancer patients despite androgen deprivation therapy. J Gerontol A Biol Sci Med Sci. 2013;68:490–8. (PMID: 2308933910.1093/gerona/gls206) Hanson ED, Srivatsan SR, Agrawal S, Menon KS, Delmonico MJ, Wang MQ, et al. Effects of strength training on physical function: influence of power, strength, and body composition. J Strength Cond Res. 2009;23:2627–37. (PMID: 19910811296687310.1519/JSC.0b013e3181b2297b) Hanson ED, Sakkal S, Que S, Cho E, Spielmann G, Kadife E, et al. Natural killer cell mobilization and egress following acute exercise in men with prostate cancer. Exp Physiol. 2020;105:1524–39. (PMID: 3271555010.1113/EP088627) Cella D, Nichol MB, Eton D, Nelson JB, Mulani P. Estimating clinically meaningful changes for the Functional Assessment of Cancer Therapy–Prostate: results from a clinical trial of patients with metastatic hormone-refractory prostate cancer. Value Health. 2009;12:124–9. (PMID: 1864726010.1111/j.1524-4733.2008.00409.x) Cormie P, Newton RU, Spry N, Joseph D, Taaffe DR, Galvao DA. Safety and efficacy of resistance exercise in prostate cancer patients with bone metastases. Prostate Cancer Prostatic Dis. 2013;16:328–35. (PMID: 2391730810.1038/pcan.2013.22) Galvao DA, Taaffe DR, Spry N, Cormie P, Joseph D, Chambers SK, et al. Exercise preserves physical function in prostate cancer patients with bone metastases. Med Sci Sports Exerc. 2018;50:393–9. (PMID: 2903601610.1249/MSS.0000000000001454) Smith MR, Finkelstein JS, McGovern FJ, Zietman AL, Fallon MA, Schoenfeld DA, et al. Changes in body composition during androgen deprivation therapy for prostate cancer. J Clin Endocrinol Metab. 2002;87:599–603. (PMID: 1183629110.1210/jcem.87.2.8299) Hamilton EJ, Gianatti E, Strauss BJ, Wentworth J, Lim-Joon D, Bolton D, et al. Increase in visceral and subcutaneous abdominal fat in men with prostate cancer treated with androgen deprivation therapy. Clin Endocrinol. 2011;74:377–83. (PMID: 10.1111/j.1365-2265.2010.03942.x) Alibhai SM, Breunis H, Timilshina N, Johnston C, Tomlinson G, Tannock I, et al. Impact of androgen-deprivation therapy on physical function and quality of life in men with nonmetastatic prostate cancer. J Clin Oncol. 2010;28:5038–45. (PMID: 2104171510.1200/JCO.2010.29.8091) Storer TW, Miciek R, Travison TG. Muscle function, physical performance and body composition changes in men with prostate cancer undergoing androgen deprivation therapy. Asian J Androl. 2012;14:204–21. (PMID: 22367184373509710.1038/aja.2011.104) Pondal M, del Ser T. Normative data and determinants for the timed “up and go” test in a population-based sample of elderly individuals without gait disturbances. J Geriatr Phys Ther. 2008;31:57–63. (PMID: 1985655110.1519/00139143-200831020-00004) Barry E, Galvin R, Keogh C, Horgan F, Fahey T. Is the Timed Up and Go test a useful predictor of risk of falls in community dwelling older adults: a systematic review and meta-analysis. BMC Geriatr. 2014;14:14. (PMID: 24484314392423010.1186/1471-2318-14-14) Beer TM, Armstrong AJ, Rathkopf DE, Loriot Y, Sternberg CN, Higano CS, et al. Enzalutamide in metastatic prostate cancer before chemotherapy. N Engl J Med. 2014;371:424–33. (PMID: 24881730441893110.1056/NEJMoa1405095) Cesari M, Kritchevsky SB, Penninx BW, Nicklas BJ, Simonsick EM, Newman AB, et al. Prognostic value of usual gait speed in well-functioning older people—results from the Health, Aging and Body Composition Study. J Am Geriatr Soc. 2005;53:1675–80. (PMID: 1618116510.1111/j.1532-5415.2005.53501.x) Studenski S, Perera S, Wallace D, Chandler JM, Duncan PW, Rooney E, et al. Physical performance measures in the clinical setting. J Am Geriatr Soc. 2003;51:314–22. (PMID: 1258857410.1046/j.1532-5415.2003.51104.x) Chen L, Nelson DR, Zhao Y, Cui Z, Johnston JA. Relationship between muscle mass and muscle strength, and the impact of comorbidities: a population-based, cross-sectional study of older adults in the United States. BMC Geriatr. 2013;13:74. (PMID: 23865675376510910.1186/1471-2318-13-74) Bean JF, Leveille SG, Kiely DK, Bandinelli S, Guralnik JM, Ferrucci L. A comparison of leg power and leg strength within the InCHIANTI study: which influences mobility more? J Gerontol A Biol Sci Med Sci. 2003;58:728–33. (PMID: 1290253110.1093/gerona/58.8.M728) Ramage MI, Skipworth RJE. The relationship between muscle mass and function in cancer cachexia: smoke and mirrors? Curr Opin Support Palliat Care. 2018;12:439–44. (PMID: 3013813110.1097/SPC.0000000000000381) Hanson ED, Wagoner CW, Anderson T, Battaglini CL. The independent effects of strength training in cancer survivors: a systematic review. Curr Oncol Rep. 2016;18:31. (PMID: 2702550510.1007/s11912-016-0511-3) Brucker PS, Yost K, Cashy J, Webster K, Cella D. General population and cancer patient norms for the Functional Assessment of Cancer Therapy-General (FACT-G). Eval Health Prof. 2005;28:192–211. (PMID: 1585177310.1177/0163278705275341) Fizazi K, Tran N, Fein L, Matsubara N, Rodriguez-Antolin A, Alekseev BY, et al. Abiraterone acetate plus prednisone in patients with newly diagnosed high-risk metastatic castration-sensitive prostate cancer (LATITUDE): final overall survival analysis of a randomised, double-blind, phase 3 trial. Lancet Oncol. 2019;20:686–700. (PMID: 3098793910.1016/S1470-2045(19)30082-8) Chen Z, Zhang Y, Lu C, Zeng H, Schumann M, Cheng S. Supervised physical training enhances muscle strength but not muscle mass in prostate cancer patients undergoing androgen deprivation therapy: a systematic review and meta-analysis. Front Physiol. 2019;10:843. (PMID: 31333495661866510.3389/fphys.2019.00843) Hanson ED, Betik AC, Timpani CA, Tarle J, Zhang X, Hayes A. Testosterone suppression does not exacerbate disuse atrophy and impairs muscle recovery that is not rescued by high protein. J Appl Physiol. (1985) 2020;129:5–16. (PMID: 10.1152/japplphysiol.00752.2019) |
| معلومات مُعتمدة: | P30 AG028747 United States AG NIA NIH HHS; R21 CA127784 United States CA NCI NIH HHS; R01 AG018336 United States AG NIA NIH HHS; T32 AG000268 United States AG NIA NIH HHS |
| المشرفين على المادة: | 0 (Androgen Antagonists) |
| تواريخ الأحداث: | Date Created: 20210126 Date Completed: 20220201 Latest Revision: 20230130 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC8310529 |
| DOI: | 10.1038/s41391-020-00317-w |
| PMID: | 33495569 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1476-5608 |
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| DOI: | 10.1038/s41391-020-00317-w |