دورية أكاديمية
Body composition, physical function and quality of life in healthy men and across different stages of prostate cancer.
العنوان: | Body composition, physical function and quality of life in healthy men and across different stages of prostate cancer. |
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المؤلفون: | Hanson ED; Department of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. edhanson@email.unc.edu.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. edhanson@email.unc.edu.; Institute of Health and Sport, Victoria University, Melbourne, VIC, Australia. edhanson@email.unc.edu., Stopforth CK; Department of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Alzer M; Department of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Carver J; Department of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Lucas AR; Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, NC, USA.; Virginia Commonwealth University, Richmond, VA, USA., Whang YE; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Division of Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Milowsky MI; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Division of Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Bartlett DB; Division of Medical Oncology, Duke Cancer Institute, Duke University, Durham, NC, USA., Harrison MR; Division of Medical Oncology, Duke Cancer Institute, Duke University, Durham, NC, USA., Hayes A; Institute of Health and Sport, Victoria University, Melbourne, VIC, Australia.; Australian Institute for Musculoskeletal Science, Victoria University, Melbourne, VIC, Australia., Bitting RL; Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, NC, USA., Deal AM; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Hackney AC; Department of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Nutrition, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Battaglini CL; Department of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. |
المصدر: | Prostate cancer and prostatic diseases [Prostate Cancer Prostatic Dis] 2021 Sep; Vol. 24 (3), pp. 725-732. Date of Electronic Publication: 2021 Jan 25. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural |
اللغة: | English |
بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9815755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5608 (Electronic) Linking ISSN: 13657852 NLM ISO Abbreviation: Prostate Cancer Prostatic Dis Subsets: MEDLINE |
أسماء مطبوعة: | Publication: <2002->: London : Nature Publishing Group Original Publication: Houndmills, Basingstoke, UK : Stockton Press, c1997- |
مواضيع طبية MeSH: | Body Composition* , Exercise* , Quality of Life* , Walking*, Androgen Antagonists/*therapeutic use , Neoplasms, Hormone-Dependent/*pathology , Prostatic Neoplasms/*pathology, Aged ; Case-Control Studies ; Cross-Sectional Studies ; Follow-Up Studies ; Humans ; Male ; Neoplasms, Hormone-Dependent/drug therapy ; Neoplasms, Hormone-Dependent/psychology ; Prognosis ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/psychology |
مستخلص: | Background: Androgen deprivation therapy (ADT) for prostate cancer (PC) has detrimental effects on physical function and quality of life (QoL), but the addition of androgen receptor signalling inhibitors (ARSI) on these outcomes is unclear. Purpose: To compare body composition, physical function, and QoL across progressive stages of PC and non-cancer controls (CON). Methods: In men with hormone sensitive PC (HSPC, n = 43) or metastatic castration-resistant PC (mCRPC, n = 22) or CON (n = 37), relative and absolute lean and fat mass, physical function (6 m walk, chair stands, timed up and go [TUG], stair climb), and QoL were determined. Results: Relative body composition differed amongst all groups, along with ~39% greater absolute fat mass in mCRPC vs. CON. TUG and chair stands were ~71% and ~33% slower in mCRPC compared to both CON and HSPC, whereas stair climb was ~29% and 6 m walk was ~18% slower in mCRPC vs. CON. Relative body composition was correlated with physical function (r = 0.259-0.385). Clinically relevant differences for mCRPC were observed for overall QoL and several subscales vs. CON, although body composition and physical function did not influence QoL. Conclusions: PC progression is associated with deteriorations in body composition and physical function. As ADT length was similar between groups, ARSI use for mCRPC likely contributed in part to these changes. Given the difficulties of improving lean mass during ADT, interventions that reduce adiposity may lessen the side effects of hormone therapy. (© 2021. The Author(s), under exclusive licence to Springer Nature Limited part of Springer Nature.) |
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معلومات مُعتمدة: | P30 AG028747 United States AG NIA NIH HHS; R21 CA127784 United States CA NCI NIH HHS; R01 AG018336 United States AG NIA NIH HHS; T32 AG000268 United States AG NIA NIH HHS |
المشرفين على المادة: | 0 (Androgen Antagonists) |
تواريخ الأحداث: | Date Created: 20210126 Date Completed: 20220201 Latest Revision: 20230130 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC8310529 |
DOI: | 10.1038/s41391-020-00317-w |
PMID: | 33495569 |
قاعدة البيانات: | MEDLINE |
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