دورية أكاديمية
Extracellular matrix metalloproteinase expression in endometrial tissue after arterial embolization of myomas.
| العنوان: | Extracellular matrix metalloproteinase expression in endometrial tissue after arterial embolization of myomas. |
|---|---|
| المؤلفون: | Chazan FL; Departamento de Ginecologia, Universidade Federal de Sao Paulo, Sao Paulo, SP, BR., Bonetti TCS; Departamento de Ginecologia, Universidade Federal de Sao Paulo, Sao Paulo, SP, BR., Gomes MTV; Departamento de Ginecologia, Universidade Federal de Sao Paulo, Sao Paulo, SP, BR., Fornazari VAV; Departamento de Diagnostico por Imagem, Universidade Federal de Sao Paulo, Sao Paulo, SP, BR., Girão MJBC; Departamento de Ginecologia, Universidade Federal de Sao Paulo, Sao Paulo, SP, BR., Bonduki CE; Departamento de Ginecologia, Universidade Federal de Sao Paulo, Sao Paulo, SP, BR. |
| المصدر: | Clinics (Sao Paulo, Brazil) [Clinics (Sao Paulo)] 2021 Jan 22; Vol. 76, pp. e2145. Date of Electronic Publication: 2021 Jan 22 (Print Publication: 2021). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 101244734 Publication Model: eCollection Cited Medium: Internet ISSN: 1980-5322 (Electronic) Linking ISSN: 18075932 NLM ISO Abbreviation: Clinics (Sao Paulo) Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2022- : [New York] : Elsevier Original Publication: São Paulo, SP : Hospital das Clínicas, Faculty of Medicine, University of São Paulo, [2005]- |
| مواضيع طبية MeSH: | Endometrium* , Myoma*, Extracellular Matrix ; Female ; Humans ; Metalloproteases ; Uterine Artery |
| مستخلص: | Objectives: Arterial embolization of myomas (AEM) is controversial because of the changes that occur in the extracellular matrix (ECM) of the endometrium and its effect on gestational success in infertile patients desiring reproductive capability. Therefore, we performed this study on the expression of genes in the ECM of the endometrium, such as those coding metalloproteinases (MMP), before and 6 months after embolization of the uterine arteries. Methods: Seven women with leiomyomas were evaluated, and MMP3 and MMP10 levels were measured. The women underwent pelvic nuclear magnetic resonance (NMR), examination, and endometrial biopsy between the 20th and 24th day of the menstrual cycle, and pre- and post-AEM (after 6 months). For data analysis, the Cq comparative method, also known as the 2-ΔΔCT method, was used to calculate the relative quantities of MMP gene expression among the samples collected. Results: There was a significant decrease by 9.52 times in the expression of MMP3 (p=0.007), and a non-significant change in the expression of MMP10 (p=0.22) in post-AEM-treated women than pre-AEM-treated women. Conclusions: The results suggest that ECM continues to undergo tissue remodeling 6 months after AEM, at least with regard to MMP3 expression, suggesting that AEM affects the ECM for at least 6 months after the procedure. |
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| المشرفين على المادة: | EC 3.4.- (Metalloproteases) |
| تواريخ الأحداث: | Date Created: 20210127 Date Completed: 20210426 Latest Revision: 20220629 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC7811830 |
| DOI: | 10.6061/clinics/2021/e2145 |
| PMID: | 33503183 |
| قاعدة البيانات: | MEDLINE |
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