دورية أكاديمية
Serotonin depletion amplifies distinct human social emotions as a function of individual differences in personality.
| العنوان: | Serotonin depletion amplifies distinct human social emotions as a function of individual differences in personality. |
|---|---|
| المؤلفون: | Kanen JW; Department of Psychology, University of Cambridge, Cambridge, UK. jonathan.kanen@gmail.com.; Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK. jonathan.kanen@gmail.com., Arntz FE; Department of Psychology, University of Cambridge, Cambridge, UK.; Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.; Department of Psychology, Leiden University, Leiden, The Netherlands., Yellowlees R; Department of Psychology, University of Cambridge, Cambridge, UK.; Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.; Section of Eating Disorders, Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Cardinal RN; Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.; Department of Psychiatry, University of Cambridge, Cambridge, UK.; Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK., Price A; Department of Psychiatry, University of Cambridge, Cambridge, UK.; Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK., Christmas DM; Department of Psychiatry, University of Cambridge, Cambridge, UK.; Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK., Apergis-Schoute AM; Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.; Department of Neuroscience, Psychology, and Behaviour, University of Leicester, Leicester, UK., Sahakian BJ; Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.; Department of Psychiatry, University of Cambridge, Cambridge, UK., Robbins TW; Department of Psychology, University of Cambridge, Cambridge, UK.; Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK. |
| المصدر: | Translational psychiatry [Transl Psychiatry] 2021 Feb 01; Vol. 11 (1), pp. 81. Date of Electronic Publication: 2021 Feb 01. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101562664 Publication Model: Electronic Cited Medium: Internet ISSN: 2158-3188 (Electronic) Linking ISSN: 21583188 NLM ISO Abbreviation: Transl Psychiatry Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Nature Pub. Group |
| مواضيع طبية MeSH: | Emotions* , Individuality* , Personality* , Serotonin*, Double-Blind Method ; Empathy ; Healthy Volunteers ; Humans ; Tryptophan |
| مستخلص: | Serotonin is involved in a wide range of mental capacities essential for navigating the social world, including emotion and impulse control. Much recent work on serotonin and social functioning has focused on decision-making. Here we investigated the influence of serotonin on human emotional reactions to social conflict. We used a novel computerised task that required mentally simulating social situations involving unjust harm and found that depleting the serotonin precursor tryptophan-in a double-blind randomised placebo-controlled design-enhanced emotional responses to the scenarios in a large sample of healthy volunteers (n = 73), and interacted with individual differences in trait personality to produce distinctive human emotions. Whereas guilt was preferentially elevated in highly empathic participants, annoyance was potentiated in those high in trait psychopathy, with medium to large effect sizes. Our findings show how individual differences in personality, when combined with fluctuations of serotonin, may produce diverse emotional phenotypes. This has implications for understanding vulnerability to psychopathology, determining who may be more sensitive to serotonin-modulating treatments, and casts new light on the functions of serotonin in emotional processing. |
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| معلومات مُعتمدة: | United Kingdom Wellcome Trust; MC_PC_17213 United Kingdom MRC_ Medical Research Council; 104631/Z/14/Z Wellcome Trust (Wellcome) |
| المشرفين على المادة: | 333DO1RDJY (Serotonin) 8DUH1N11BX (Tryptophan) |
| تواريخ الأحداث: | Date Created: 20210201 Date Completed: 20210628 Latest Revision: 20240330 |
| رمز التحديث: | 20240330 |
| مُعرف محوري في PubMed: | PMC7847998 |
| DOI: | 10.1038/s41398-020-00880-9 |
| PMID: | 33518708 |
| قاعدة البيانات: | MEDLINE |
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