دورية أكاديمية
أعرض في EDS

General Anaesthesia Shifts the Murine Circadian Clock in a Time-Dependant Fashion.

التفاصيل البيبلوغرافية
العنوان: General Anaesthesia Shifts the Murine Circadian Clock in a Time-Dependant Fashion.
المؤلفون: Ludin NM; Department of Anaesthesiology, School of Medicine, University of Auckland, 1142 Auckland, New Zealand., Orts-Sebastian A; Department of Anaesthesiology, School of Medicine, University of Auckland, 1142 Auckland, New Zealand., Cheeseman JF; Department of Anaesthesiology, School of Medicine, University of Auckland, 1142 Auckland, New Zealand., Chong J; Department of Anaesthesiology, School of Medicine, University of Auckland, 1142 Auckland, New Zealand., Merry AF; Department of Anaesthesiology, School of Medicine, University of Auckland, 1142 Auckland, New Zealand., Cumin D; Department of Anaesthesiology, School of Medicine, University of Auckland, 1142 Auckland, New Zealand., Yamazaki S; Department of Neuroscience, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Pawley MDM; Department of Anaesthesiology, School of Medicine, University of Auckland, 1142 Auckland, New Zealand.; School of Natural and Computational Sciences, Massey University, 0745 Auckland, New Zealand., Warman GR; Department of Anaesthesiology, School of Medicine, University of Auckland, 1142 Auckland, New Zealand.
المصدر: Clocks & sleep [Clocks Sleep] 2021 Jan 26; Vol. 3 (1), pp. 87-97. Date of Electronic Publication: 2021 Jan 26.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101736579 Publication Model: Electronic Cited Medium: Internet ISSN: 2624-5175 (Electronic) Linking ISSN: 26245175 NLM ISO Abbreviation: Clocks Sleep Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Basel, Switzerland] : MDPI, [2019]-
مستخلص: Following general anaesthesia (GA), patients frequently experience sleep disruption and fatigue, which has been hypothesized to result at least in part by GA affecting the circadian clock. Here, we provide the first comprehensive time-dependent analysis of the effects of the commonly administered inhalational anaesthetic, isoflurane, on the murine circadian clock, by analysing its effects on (a) behavioural locomotor rhythms and (b) PER2::LUC expression in the suprachiasmatic nuclei (SCN) of the mouse brain. Behavioural phase shifts elicited by exposure of mice (n = 80) to six hours of GA (2% isoflurane) were determined by recording wheel-running rhythms in constant conditions (DD). Phase shifts in PER2::LUC expression were determined by recording bioluminescence in organotypic SCN slices (n = 38) prior to and following GA exposure (2% isoflurane). Full phase response curves for the effects of GA on behaviour and PER2::LUC rhythms were constructed, which show that the effects of GA are highly time-dependent. Shifts in SCN PER2 expression were much larger than those of behaviour (c. 0.7 h behaviour vs. 7.5 h PER2::LUC). We discuss the implications of this work for understanding how GA affects the clock, and how it may inform the development of chronotherapeutic strategies to reduce GA-induced phase-shifting in patients.
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معلومات مُعتمدة: N00014-13-1-0879 Office of Naval Research Global; Doctoral Scholarship to NLM University of Auckland
فهرسة مساهمة: Keywords: PERIOD2::LUC; circadian clock; clock gene; general anaesthesia; phase response curve
تواريخ الأحداث: Date Created: 20210203 Latest Revision: 20210305
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC7930986
DOI: 10.3390/clockssleep3010006
PMID: 33530488
قاعدة البيانات: MEDLINE
الوصف
تدمد:2624-5175
DOI:10.3390/clockssleep3010006