دورية أكاديمية
National outcomes and characteristics of patients admitted to Swedish intensive care units for COVID-19: A registry-based cohort study.
العنوان: | National outcomes and characteristics of patients admitted to Swedish intensive care units for COVID-19: A registry-based cohort study. |
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المؤلفون: | Chew MS; From the Departments of Anaesthesia and Intensive Care, Biomedical and Clinical Sciences (MSC, PJB, RÅ, HA), Department of Anaesthesia and Intensive Care, Vrinnevi Hospital, Norrköping, Department of Thoracic and Vascular Surgery, Medical and Health Sciences, Linköping University (LE), Department of Anaesthesia, Intensive Care and Perioperative Services, Umeå University Hospital, Umeå (RKB), Department of Public Health Reporting, Public Health Agency of Sweden (AT), Department of Biomedical and Clinical Sciences, Center for Social and Affective Neuroscience, Linköping University, Sweden (SM)., Blixt PJ, Åhman R, Engerström L, Andersson H, Berggren RK, Tegnell A, McIntyre S |
المصدر: | European journal of anaesthesiology [Eur J Anaesthesiol] 2021 Apr 01; Vol. 38 (4), pp. 335-343. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Lippincott Williams & Wilkins, 2009- Country of Publication: England NLM ID: 8411711 Publication Model: Print Cited Medium: Internet ISSN: 1365-2346 (Electronic) Linking ISSN: 02650215 NLM ISO Abbreviation: Eur J Anaesthesiol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Cambridge : Lippincott Williams & Wilkins, 2009- Original Publication: Oxford ; Boston : Published on behalf of the European Academy of Anaesthesiology by Blackwell Scientific, 1984-2004 |
مواضيع طبية MeSH: | Hospital Mortality*, COVID-19/*therapy , Intensive Care Units/*statistics & numerical data , Patient Admission/*statistics & numerical data , SARS-CoV-2/*isolation & purification, Adult ; Aged ; Aged, 80 and over ; COVID-19/diagnosis ; COVID-19/mortality ; Cohort Studies ; Female ; Humans ; Italy/epidemiology ; Male ; Middle Aged ; Prospective Studies ; Registries ; Sweden/epidemiology |
مستخلص: | Background: Mortality among patients admitted to intensive care units (ICUs) with COVID-19 is unclear due to variable follow-up periods. Few nationwide data are available to compare risk factors, treatment and outcomes of COVID-19 patients after ICU admission. Objective: To evaluate baseline characteristics, treatments and 30-day outcomes of patients admitted to Swedish ICUs with COVID-19. Design: Registry-based cohort study with prospective data collection. Setting: Admissions to Swedish ICUs from 6 March to 6 May 2020 with laboratory confirmed COVID-19 disease. Participants: Adult patients admitted to Swedish ICUs. Exposures: Baseline characteristics, intensive care treatments and organ failures. Main Outcomes and Measures: The primary outcome was 30-day all-cause mortality. A multivariable model was used to determine the independent association between potential predictor variables and death. Results: We identified 1563 patients with complete 30-day follow-up. The 30-day all-cause mortality was 26.7%. Median age was 61 [52 to 69], Simplified Acute Physiology Score III (SAPS III) was 53 [46 to 59] and 62.5% had at least one comorbidity. Median PaO2/FiO2 on admission was 97.5 [75.0 to 140.6] mmHg, 74.7% suffered from moderate-to-severe acute respiratory failure. Age, male sex [adjusted odds ratio (aOR) 1.5 (1.1 to 2.2)], SAPS III score [aOR 1.3 (1.2 to 1.4)], severe respiratory failure [aOR 3.0 (2.0 to 4.7)], specific COVID-19 pharmacotherapy [aOR 1.4 (1.0 to 1.9)] and continuous renal replacement therapy [aOR 2.1 (1.5 to 3.0)] were associated with increased mortality. Except for chronic lung disease, the presence of comorbidities was not independently associated with mortality. Conclusions: Thirty-day mortality rate in COVID-19 patients admitted to Swedish ICUs is generally lower than previously reported despite a severe degree of hypoxaemia on admission. Mortality was driven by age, baseline disease severity, the presence and degree of organ failure, rather than pre-existing comorbidities. Trial Registration No: NCT04462393. (Copyright © 2021 European Society of Anaesthesiology and Intensive Care. Unauthorized reproduction of this article is prohibited.) |
التعليقات: | Comment in: Eur J Anaesthesiol. 2021 Apr 1;38(4):331-332. (PMID: 33661825) |
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سلسلة جزيئية: | ClinicalTrials.gov NCT04462393 |
تواريخ الأحداث: | Date Created: 20210203 Date Completed: 20210316 Latest Revision: 20210506 |
رمز التحديث: | 20221213 |
DOI: | 10.1097/EJA.0000000000001459 |
PMID: | 33534266 |
قاعدة البيانات: | MEDLINE |
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