دورية أكاديمية
أعرض في EDS

The placental lipidome of maternal antenatal depression predicts socio-emotional problems in the offspring.

التفاصيل البيبلوغرافية
العنوان: The placental lipidome of maternal antenatal depression predicts socio-emotional problems in the offspring.
المؤلفون: Wong G; Singapore Institute for Clinical Sciences (SICS), A*STAR, Brenner Centre for Molecular Medicine, Singapore, Singapore., Weir JM; Baker IDI Heart and Diabetes Institute, Melbourne, Australia., Mishra P; Singapore Institute for Clinical Sciences (SICS), A*STAR, Brenner Centre for Molecular Medicine, Singapore, Singapore., Huynh K; Baker IDI Heart and Diabetes Institute, Melbourne, Australia., Nijagal B; Metabolomics Australia, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Australia., Gupta V; Singapore Institute for Clinical Sciences (SICS), A*STAR, Brenner Centre for Molecular Medicine, Singapore, Singapore., Broekman BFP; Singapore Institute for Clinical Sciences (SICS), A*STAR, Brenner Centre for Molecular Medicine, Singapore, Singapore.; Department of Psychiatry, OLVG and Amsterdam UMC, VU University, Amsterdam, the Netherlands., Chong MF; Singapore Institute for Clinical Sciences (SICS), A*STAR, Brenner Centre for Molecular Medicine, Singapore, Singapore.; Saw Swee Hock School of Public Health, National University of Singapore (NUS) and National University Health System (NUHS), Singapore, Singapore., Chan SY; Singapore Institute for Clinical Sciences (SICS), A*STAR, Brenner Centre for Molecular Medicine, Singapore, Singapore.; Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, Singapore., Tan KH; KK Women's and Children's Hospital, Singapore, Singapore., Tull D; Metabolomics Australia, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Australia., McConville M; Metabolomics Australia, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Australia., Calder PC; School of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.; NIHR Southampton Biomedical Research Centre, Southampton University Hospital NHS Foundation Trust and University of Southampton, Southampton, UK., Godfrey KM; NIHR Southampton Biomedical Research Centre, Southampton University Hospital NHS Foundation Trust and University of Southampton, Southampton, UK.; MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK., Chong YS; Singapore Institute for Clinical Sciences (SICS), A*STAR, Brenner Centre for Molecular Medicine, Singapore, Singapore.; Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, Singapore., Gluckman PD; Singapore Institute for Clinical Sciences (SICS), A*STAR, Brenner Centre for Molecular Medicine, Singapore, Singapore.; Centre for Human Evolution, Adaptation and Disease, Liggins Institute, University of Auckland, Auckland, New Zealand., Meaney MJ; Singapore Institute for Clinical Sciences (SICS), A*STAR, Brenner Centre for Molecular Medicine, Singapore, Singapore.; Sackler Program for Epigenetics & Psychobiology at McGill University, Douglas Mental Health University Institute, McGill University, Montréal, Canada., Meikle PJ; Baker IDI Heart and Diabetes Institute, Melbourne, Australia., Karnani N; Singapore Institute for Clinical Sciences (SICS), A*STAR, Brenner Centre for Molecular Medicine, Singapore, Singapore. neerja_karnani@sics.a-star.edu.sg.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, Singapore. neerja_karnani@sics.a-star.edu.sg.
المصدر: Translational psychiatry [Transl Psychiatry] 2021 Feb 04; Vol. 11 (1), pp. 107. Date of Electronic Publication: 2021 Feb 04.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101562664 Publication Model: Electronic Cited Medium: Internet ISSN: 2158-3188 (Electronic) Linking ISSN: 21583188 NLM ISO Abbreviation: Transl Psychiatry Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, NY : Nature Pub. Group
مواضيع طبية MeSH: Depression* , Fatty Acids, Omega-3*, Child ; Docosahexaenoic Acids ; Female ; Humans ; Lipidomics ; Placenta ; Pregnancy
مستخلص: While maternal mental health strongly influences neurodevelopment and health in the offspring, little is known about the determinants of inter-individual variation in the mental health of mothers. Likewise, the in utero biological pathways by which variation in maternal mental health affects offspring development remain to be defined. Previous studies implicate lipids, consistent with a known influence on cognitive and emotional function, but the relevance for maternal mental health and offspring neurodevelopment is unclear. This study characterizes the placental and circulatory lipids in antenatal depression, as well as socio-emotional outcomes in the offspring. Targeted liquid chromatography-mass spectrometry covering 470 lipid species was performed on placenta from 186 women with low (n = 70) or high (n = 116) levels of antenatal depressive symptoms assessed using the Edinburgh Postnatal Depression Scale at 26 weeks' gestation. Child socio-emotional outcomes were assessed from the Child Behavior Check List (CBCL) at 48 months. Seventeen placental lipid species showed an inverse association with antenatal EPDS scores. Specifically, lower levels of phospholipids containing LC-PUFAs: omega-3 docosapentaenoic acid (DPA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and omega-6 arachidonic acid (AA) were significantly associated with depressive symptoms. Additional measurement of LC-PUFA in antenatal plasma samples at mid-gestation confirmed the reduced circulation of these specific fatty acids in mothers. Reduced concentration of the placental phospholipids also predicted poorer socio-emotional outcomes in the offspring. This study provides new insights into the role of the materno-fetal lipid cross-talk as a mechanism linking maternal mental health to that of the offspring. These findings show the potential utility of nutritional approaches among pregnant women with depressive symptoms to reduce offspring risk for later socio-emotional problems.
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معلومات مُعتمدة: MC_PC_21000 United Kingdom MRC_ Medical Research Council; MC_PC_21001 United Kingdom MRC_ Medical Research Council; MC_PC_21003 United Kingdom MRC_ Medical Research Council
المشرفين على المادة: 0 (Fatty Acids, Omega-3)
25167-62-8 (Docosahexaenoic Acids)
تواريخ الأحداث: Date Created: 20210205 Date Completed: 20210628 Latest Revision: 20220317
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC7862650
DOI: 10.1038/s41398-021-01208-x
PMID: 33542173
قاعدة البيانات: MEDLINE
الوصف
تدمد:2158-3188
DOI:10.1038/s41398-021-01208-x