دورية أكاديمية
أعرض في EDS

Dietary Rice Bran-Modified Human Gut Microbial Consortia Confers Protection against Colon Carcinogenesis Following Fecal Transfaunation.

التفاصيل البيبلوغرافية
العنوان: Dietary Rice Bran-Modified Human Gut Microbial Consortia Confers Protection against Colon Carcinogenesis Following Fecal Transfaunation.
المؤلفون: Parker KD; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA., Maurya AK; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA., Ibrahim H; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA.; Department of Medical Biochemistry, Faculty of Medicine, Zagazig University, Zagazig 44511, Egypt., Rao S; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA., Hove PR; Department of Microbiology, Immunology & Pathology, Colorado State University, Fort Collins, CO 80523, USA., Kumar D; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA., Kant R; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA., Raina B; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA., Agarwal R; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA., Kuhn KA; Division of Rheumatology, Department of Medicine, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045, USA., Raina K; Department of Pharmaceutical Sciences, South Dakota State University, Brookings, SD 57007, USA., Ryan EP; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA.
المصدر: Biomedicines [Biomedicines] 2021 Feb 03; Vol. 9 (2). Date of Electronic Publication: 2021 Feb 03.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101691304 Publication Model: Electronic Cited Medium: Print ISSN: 2227-9059 (Print) Linking ISSN: 22279059 NLM ISO Abbreviation: Biomedicines Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, [2013]-
مستخلص: Rice bran, removed from whole grain rice for white rice milling, has demonstrated efficacy for the control and suppression of colitis and colon cancer in multiple animal models. Dietary rice bran intake was shown to modify human stool metabolites as a result of modifications to metabolism by gut microbiota. In this study, human stool microbiota from colorectal cancer (CRC) survivors that consumed rice bran daily was examined by fecal microbiota transplantation (FMT) for protection from azoxymethane and dextran sodium sulfate (AOM/DSS) induced colon carcinogenesis in germ-free mice. Mice transfaunated with rice bran-modified microbiota communities (RMC) harbored fewer neoplastic lesions in the colon and displayed distinct enrichment of Flavonifractor and Oscillibacter associated with colon health, and the depletion of Parabacteroides distasonis correlated with increased tumor burden. Two anti-cancer metabolites, myristoylcarnitine and palmitoylcarnitine were increased in the colon of RMC transplanted mice. Trimethylamine-N-oxide (TMAO) and tartarate that are implicated in CRC development were reduced in murine colon tissue after FMT with rice bran-modified human microbiota. Findings from this study show that rice bran modified gut microbiota from humans confers protection from colon carcinogenesis in mice and suggests integrated dietary-FMT intervention strategies should be tested for colorectal cancer control, treatment, and prevention.
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معلومات مُعتمدة: 5R01CA201112 United States NH NIH HHS
فهرسة مساهمة: Keywords: colon cancer carcinogenesis; fecal microbiota transplantation; metabolome; microbiome
تواريخ الأحداث: Date Created: 20210206 Latest Revision: 20210316
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC7913285
DOI: 10.3390/biomedicines9020144
PMID: 33546192
قاعدة البيانات: MEDLINE
الوصف
تدمد:2227-9059
DOI:10.3390/biomedicines9020144