دورية أكاديمية
Intracellular Staphylococcus aureus and host cell death pathways.
| العنوان: | Intracellular Staphylococcus aureus and host cell death pathways. |
|---|---|
| المؤلفون: | Soe YM; Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia., Bedoui S; Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia., Stinear TP; Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia., Hachani A; Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia. |
| المصدر: | Cellular microbiology [Cell Microbiol] 2021 May; Vol. 23 (5), pp. e13317. Date of Electronic Publication: 2021 Feb 24. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Hindawi Country of Publication: India NLM ID: 100883691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1462-5822 (Electronic) Linking ISSN: 14625814 NLM ISO Abbreviation: Cell Microbiol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2022- : Mumbai : Hindawi Original Publication: Oxford : Wiley-Blackwell, c1999- |
| مواضيع طبية MeSH: | Apoptosis* , Host-Pathogen Interactions*, Staphylococcal Infections/*microbiology , Staphylococcus aureus/*pathogenicity , Virulence Factors/*metabolism, Animals ; Epithelium/microbiology ; Ferroptosis ; Humans ; Necroptosis ; Neutrophils/physiology ; Pathogen-Associated Molecular Pattern Molecules/metabolism ; Pyroptosis ; Staphylococcus aureus/metabolism ; Virulence |
| مستخلص: | Staphylococcus aureus is a major opportunistic human pathogen that is globally prevalent. Although S. aureus and humans may have co-evolved to the point of commensalism, the bacterium is equipped with virulence factors causing devastating infections. The adoption of an intracellular lifestyle by S. aureus is an important facet of its pathogenesis. Occupying a privileged intracellular compartment permits evasion from the bactericidal actions of host immunity and antibiotics. However, this localization exposes S. aureus to cell-intrinsic processes comprising autophagy, metabolic challenges and clearance mechanisms orchestrated by host programmed cell death pathways (PCDs), including apoptosis, pyroptosis and necroptosis. Mounting evidence suggests that S. aureus deploys pathoadaptive mechanisms that modulate the expression of its virulence factors to prevent elimination through PCD pathways. In this review, we critically analyse the current literature on the interplay between S. aureus virulence factors with the key, intertwined nodes of PCD. We discuss how S. aureus adaptation to the human host plays an essential role in the evasion of PCD, and we consider future directions to study S. aureus-PCD interactions. (© 2021 John Wiley & Sons Ltd.) |
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| فهرسة مساهمة: | Keywords: PCD; Staphylococcus aureus; apoptosis; autophagy; ferroptosis; intracellular pathogen; metabolism; necroptosis; programmed cell death; pyroptosis |
| المشرفين على المادة: | 0 (Pathogen-Associated Molecular Pattern Molecules) 0 (Virulence Factors) |
| تواريخ الأحداث: | Date Created: 20210207 Date Completed: 20211203 Latest Revision: 20211214 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1111/cmi.13317 |
| PMID: | 33550697 |
| قاعدة البيانات: | MEDLINE |
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