دورية أكاديمية
Towards establishing no observed adverse effect levels (NOAEL) for different sources of dietary phosphorus in feline adult diets: results from a 7-month feeding study.
| العنوان: | Towards establishing no observed adverse effect levels (NOAEL) for different sources of dietary phosphorus in feline adult diets: results from a 7-month feeding study. |
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| المؤلفون: | Coltherd JC; Waltham Petcare Science Institute, Melton Mowbray, LeicestershireLE14 4RT, UK., Alexander JE; Waltham Petcare Science Institute, Melton Mowbray, LeicestershireLE14 4RT, UK., Pink C; Waltham Petcare Science Institute, Melton Mowbray, LeicestershireLE14 4RT, UK., Rawlings J; Waltham Petcare Science Institute, Melton Mowbray, LeicestershireLE14 4RT, UK., Elliott J; Department of Comparative Biomedical Sciences, Royal Veterinary College, University of London, LondonNW1 0TU, UK., Haydock R; Waltham Petcare Science Institute, Melton Mowbray, LeicestershireLE14 4RT, UK., Carvell-Miller LJ; Waltham Petcare Science Institute, Melton Mowbray, LeicestershireLE14 4RT, UK., Biourge VC; Royal Canin SAS, Aimargues30470, France., Molina L; Royal Canin SAS, Aimargues30470, France., Butterwick R; Waltham Petcare Science Institute, Melton Mowbray, LeicestershireLE14 4RT, UK., Logan DW; Waltham Petcare Science Institute, Melton Mowbray, LeicestershireLE14 4RT, UK., Watson P; Waltham Petcare Science Institute, Melton Mowbray, LeicestershireLE14 4RT, UK., Bakke AM; Waltham Petcare Science Institute, Melton Mowbray, LeicestershireLE14 4RT, UK. |
| المصدر: | The British journal of nutrition [Br J Nutr] 2021 Dec 14; Vol. 126 (11), pp. 1626-1641. Date of Electronic Publication: 2021 Feb 08. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial, Veterinary; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Published on behalf of the Nutrition Society by CABI Publishing Country of Publication: England NLM ID: 0372547 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1475-2662 (Electronic) Linking ISSN: 00071145 NLM ISO Abbreviation: Br J Nutr Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2000->: Wallingford, Oxon, UK : Published on behalf of the Nutrition Society by CABI Publishing Original Publication: [Cambridge, New York] Cambridge University Press. |
| مواضيع طبية MeSH: | Phosphorus, Dietary*/adverse effects, Animals ; Cats ; Calcium ; Diet/veterinary ; Kidney ; No-Observed-Adverse-Effect Level ; Phosphorus |
| مستخلص: | High dietary phosphorus (P), particularly soluble salts, may contribute to chronic kidney disease development in cats. The aim of the present study was to assess the safety of P supplied at 1 g/1000 kcal (4184kJ) from a highly soluble P salt in P-rich dry format feline diets. Seventy-five healthy adult cats (n 25/group) were fed either a low P control (1·4 g/1000 kcal [4184kJ]; Ca:P ratio 0·97) or one of two test diets with 4 g/1000 kcal (4184 kJ); Ca:P 1·04 or 5 g/1000 kcal (4184kJ); Ca:P 1·27, both incorporating 1 g/1000 kcal (4184 kJ) sodium tripolyphosphate (STPP) - for a period of 30 weeks in a randomised parallel-group study. Health markers in blood and urine, glomerular filtration rate, renal ultrasound and bone density were assessed at baseline and at regular time points. At the end of the test period, responses following transition to a commercial diet (total P - 2·34 g/1000 kcal [4184kJ], Ca:P 1·3) for a 4-week washout period were also assessed. No adverse effects on general, kidney or bone (skeletal) function and health were observed. P and Ca balance, some serum biochemistry parameters and regulatory hormones were increased in cats fed test diets from week 2 onwards (P ≤ 0·05). Data from the washout period suggest that increased serum creatinine and urea values observed in the two test diet groups were influenced by dietary differences during the test period, and not indicative of changes in renal function. The present data suggest no observed adverse effect level for feline diets containing 1 g P/1000 kcal (4184 kJ) from STPP and total P level of up to 5 g/1000 kcal (4184 kJ) when fed for 30 weeks. |
| فهرسة مساهمة: | Keywords: Cats; Mineral regulation; Renal health; Sodium tripolyphosphate; Soluble phosphorus salt |
| المشرفين على المادة: | SY7Q814VUP (Calcium) 27YLU75U4W (Phosphorus) 0 (Phosphorus, Dietary) |
| تواريخ الأحداث: | Date Created: 20210208 Date Completed: 20231005 Latest Revision: 20231005 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1017/S0007114521000477 |
| PMID: | 33550999 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1475-2662 |
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| DOI: | 10.1017/S0007114521000477 |