تقرير
Pulmonary angiosarcoma presenting with diffuse alveolar hemorrhage: a case report.
| العنوان: | Pulmonary angiosarcoma presenting with diffuse alveolar hemorrhage: a case report. |
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| المؤلفون: | Yu M; Department of Respiratory and Critical Care Medicine, Shenzhen People's Hospital & the First Affiliated Hospital of Southern University of Science and Technology & the Second Clinical School of Jinan University & Shenzhen Municipal Institute of Respiratory Medicine, Shenzhen, China., Huang W; Department of Respiratory and Critical Care Medicine, Shenzhen People's Hospital & the First Affiliated Hospital of Southern University of Science and Technology & the Second Clinical School of Jinan University & Shenzhen Municipal Institute of Respiratory Medicine, Shenzhen, China., Wang Y; Department of Pathology, Shenzhen People's Hospital & the First Affiliated Hospital of Southern University of Science and Technology & the Second Clinical School of Jinan University & Shenzhen Municipal Institute of Respiratory Medicine, Shenzhen, China., Wang G; Department of Thoracic Surgery, Shenzhen People's Hospital & the First Affiliated Hospital of Southern University of Science and Technology & the Second Clinical School of Jinan University & Shenzhen Municipal Institute of Respiratory Medicine, Shenzhen, China., Wang L; Department of Respiratory and Critical Care Medicine, Shenzhen People's Hospital & the First Affiliated Hospital of Southern University of Science and Technology & the Second Clinical School of Jinan University & Shenzhen Municipal Institute of Respiratory Medicine, Shenzhen, China., Tao W; Department of Respiratory and Critical Care Medicine, Shenzhen People's Hospital & the First Affiliated Hospital of Southern University of Science and Technology & the Second Clinical School of Jinan University & Shenzhen Municipal Institute of Respiratory Medicine, Shenzhen, China., Faiz SA; Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Ng FH; Department of Radiology, Princess Margaret Hospital, Hong Kong, China., Li H; Department of Respiratory and Critical Care Medicine, Shenzhen People's Hospital & the First Affiliated Hospital of Southern University of Science and Technology & the Second Clinical School of Jinan University & Shenzhen Municipal Institute of Respiratory Medicine, Shenzhen, China. |
| المصدر: | Annals of translational medicine [Ann Transl Med] 2021 Jan; Vol. 9 (1), pp. 74. |
| نوع المنشور: | Case Reports |
| اللغة: | English |
| بيانات الدورية: | Publisher: AME Publishing Company Country of Publication: China NLM ID: 101617978 Publication Model: Print Cited Medium: Print ISSN: 2305-5839 (Print) Linking ISSN: 23055839 NLM ISO Abbreviation: Ann Transl Med Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: [Hong Kong] : AME Publishing Company |
| مستخلص: | This study aimed to analyze the diagnosis and treatment of one case of pulmonary angiosarcoma (PPA) retrospectively. The main manifestation of this female patient was cough, hemoptysis and dyspnea. Computed tomography (CT) of the chest revealed multiple small nodules and ground-glass patches in both lungs suggesting of diffuse alveolar hemorrhage (DAH). Laboratory examination revealed decreased hemoglobin and platelet counting, normal coagulation function. Results of rheumatic markers testing including antinuclear antibody (ANA), anti-extractable nuclear antigen antibody (ENA), vasculitis marker, and antiphospholipid antibody were negative. Tumor markers were negative. Sputum smear, sputum culture, and alveolar lavage fluid culture showed negative results. The bone marrow smear was essentially normal. The patient received methylprednisolone pulse therapy (250 mg daily × 5 days) and immunoglobin (20 d daily × 7 days) treatment, but her hemoptysis persisted. Bilateral pleural effusion drainage found a large amount of bloody effusion, but cytology of the pleural fluid showed negative results. The clinical symptoms, laboratory results, imaging findings, and pathological features of the patient were summarized, and problems in diagnosis and treatment were discussed. A thoracoscopic lung biopsy was performed and the diagnosis of PPA was confirmed by pathology and immunohistochemistry (IHC) staining. This case suggested that the possibility of PPA should be considered in patients with DAH, but with negative findings in routine examinations, lung biopsy is usually required. Competing Interests: Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/atm-20-7441). The authors have no conflicts of interest to declare. (2021 Annals of Translational Medicine. All rights reserved.) |
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| فهرسة مساهمة: | Keywords: Diffuse alveolar hemorrhage (DAH); case report; pulmonary angiosarcoma (PPA); pulmonary biopsy |
| تواريخ الأحداث: | Date Created: 20210208 Latest Revision: 20210210 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC7859806 |
| DOI: | 10.21037/atm-20-7441 |
| PMID: | 33553367 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2305-5839 |
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| DOI: | 10.21037/atm-20-7441 |