دورية أكاديمية
Quinolizidine Alkaloids from Cylicomorpha solmsii .
| العنوان: | Quinolizidine Alkaloids from Cylicomorpha solmsii . |
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| المؤلفون: | Pouny I; USR CNRS-Pierre Fabre No. 3388 ETaC, Centre de Recherche et Développement Pierre Fabre, 31035 Toulouse, France., Long C; USR CNRS-Pierre Fabre No. 3388 ETaC, Centre de Recherche et Développement Pierre Fabre, 31035 Toulouse, France., Batut M; USR CNRS-Pierre Fabre No. 3388 ETaC, Centre de Recherche et Développement Pierre Fabre, 31035 Toulouse, France., Aussagues Y; USR CNRS-Pierre Fabre No. 3388 ETaC, Centre de Recherche et Développement Pierre Fabre, 31035 Toulouse, France., Jean Valère N; Aix Marseille Université, CNRS, Centrale Marseille, Spectropole FR1739, 13397 Marseille, France., Achoundong G; Cameroon National Herbarium, BP 1601 Yaounde, Cameroon., David B; Pôle Actifs Végétaux, Institut de Recherche Pierre Fabre, 31035 Toulouse, France., Lavaud C; Université de Reims Champagne-Ardenne, Institut de Chimie Moléculaire de Reims, UMR CNRS 7312, BP 1039, 51687 Reims, Cedex 2, France., Massiot G; USR CNRS-Pierre Fabre No. 3388 ETaC, Centre de Recherche et Développement Pierre Fabre, 31035 Toulouse, France.; Université de Reims Champagne-Ardenne, Institut de Chimie Moléculaire de Reims, UMR CNRS 7312, BP 1039, 51687 Reims, Cedex 2, France. |
| المصدر: | Journal of natural products [J Nat Prod] 2021 Apr 23; Vol. 84 (4), pp. 1198-1202. Date of Electronic Publication: 2021 Feb 19. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society of Pharmacognosy Country of Publication: United States NLM ID: 7906882 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6025 (Electronic) Linking ISSN: 01633864 NLM ISO Abbreviation: J Nat Prod Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cincinnati, American Society of Pharmacognosy. |
| مواضيع طبية MeSH: | Alkaloids/*pharmacology , Antineoplastic Agents, Phytogenic/*pharmacology , Caricaceae/*chemistry , Quinolizidines/*pharmacology, Alkaloids/isolation & purification ; Antineoplastic Agents, Phytogenic/isolation & purification ; Cameroon ; HCT116 Cells ; Humans ; Molecular Structure ; Phytochemicals/isolation & purification ; Phytochemicals/pharmacology ; Plant Leaves/chemistry ; Quinolizidines/isolation & purification |
| مستخلص: | Five new quinolizidine alkaloids were isolated from the leaves of Cylicomorpha solmstii (Urb.) Urb. (Caricaceae) and named cylicomorphins A-E ( 1 - 5 ). They all are ester derivatives of the same basic quinolizidine skeleton bearing hydroxy, methyl, and ethanoic acid substituents. Their structures were mainly established by NMR spectroscopy, and the absolute configuration is proposed on the basis of VCD data and Mosher ester derivatization. Compound 5 displayed cytotoxicity in the 10 μM range against an HCT-116 cell line. |
| المشرفين على المادة: | 0 (Alkaloids) 0 (Antineoplastic Agents, Phytogenic) 0 (Phytochemicals) 0 (Quinolizidines) |
| تواريخ الأحداث: | Date Created: 20210219 Date Completed: 20211119 Latest Revision: 20211119 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1021/acs.jnatprod.0c01261 |
| PMID: | 33606529 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 1520-6025 |
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| DOI: | 10.1021/acs.jnatprod.0c01261 |