دورية أكاديمية
Chronic osteo-articular changes in patients with sickle cell disease.
| العنوان: | Chronic osteo-articular changes in patients with sickle cell disease. |
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| المؤلفون: | Ferreira TFA; Clinical Hospital of Federal University Triângulo Mineiro, Functional Units Rom, Av. Getúlio Guaritá, 130, B. Nossa Senhora da Abadia, CEP 38.025-440, Uberaba, MG, Brazil. taciferreira@yahoo.com.br., Dos Santos APT; Clinical Hospital of Federal University Triângulo Mineiro, Uberaba, MG, Brazil., Leal AS; Federal University of Triângulo Mineiro, Uberaba, MG, Brazil., de Araújo Pereira G; Federal University of Triângulo Mineiro, Uberaba, MG, Brazil., Silva SS; Federal University of Triângulo Mineiro, Uberaba, MG, Brazil., Moraes-Souza H; Federal University of Triângulo Mineiro, Uberaba, MG, Brazil. |
| المصدر: | Advances in rheumatology (London, England) [Adv Rheumatol] 2021 Feb 19; Vol. 61 (1), pp. 11. Date of Electronic Publication: 2021 Feb 19. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 101734172 Publication Model: Electronic Cited Medium: Internet ISSN: 2523-3106 (Electronic) Linking ISSN: 25233106 NLM ISO Abbreviation: Adv Rheumatol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [London] : BioMed Central, [2018]- |
| مواضيع طبية MeSH: | Anemia, Sickle Cell/*complications , Osteoarthritis/*diagnostic imaging , Osteonecrosis/*diagnostic imaging, Adolescent ; Adult ; Anemia, Sickle Cell/blood ; Anemia, Sickle Cell/drug therapy ; Antisickling Agents/therapeutic use ; Cross-Sectional Studies ; Female ; Hemoglobin, Sickle/genetics ; Humans ; Hydroxyurea/therapeutic use ; Male ; Osteoarthritis/epidemiology ; Osteonecrosis/epidemiology ; Skin Pigmentation ; Young Adult |
| مستخلص: | Background: Sickle cell disease (SCD) is an autosomal recessive genetic disease in which a mutation occurs in the β-globin chain gene, resulting in abnormal hemoglobin levels. In an environment with reduced oxygen concentration, red blood cells change their conformation, resulting in chronic hemolysis and consequent anemia and vaso-occlusive crises with injuries to several organs, with a significant impairment of the osteoarticular system. This study aimed to verify the chronic osteoarticular alterations and their association with clinical and laboratory characteristics of patients with SCD with a more severe phenotype (SS and Sβ 0 ), on a steady-state fasis. Methods: Fifty-five patients were referred to a medical consultation with a specialized assessment of the locomotor system, followed by laboratory tests and radiographic examinations. Results: In total, 74.5% patients had hemoglobinopathy SS; 67.3% were female; and 78.2% were non-whites. The mean patient age was 30.5 years. Most patients (61.8%) reported up to three crises per year, with a predominance of high-intensity pain (65.5%). Radiographic alterations were present in 80% patients. A total of 140 lesions were identified, most which were located in the spine, femur, and shoulders. Most lesions were osteonecrosis and osteoarthritis and were statistically associated with the non-use of hydroxyurea. Conclusions: There was a high prevalence of chronic osteoarticular alterations, which was statistically associated only with the non-regular use of hydroxyurea. |
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| فهرسة مساهمة: | Keywords: Hydroxyurea; Osteoarthritis; Osteonecrosis; Osteopenia; Sickle cell disease |
| المشرفين على المادة: | 0 (Antisickling Agents) 0 (Hemoglobin, Sickle) X6Q56QN5QC (Hydroxyurea) |
| تواريخ الأحداث: | Date Created: 20210220 Date Completed: 20211101 Latest Revision: 20211101 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1186/s42358-021-00169-5 |
| PMID: | 33608055 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 2523-3106 |
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| DOI: | 10.1186/s42358-021-00169-5 |