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Association of bedtime with mortality and major cardiovascular events: an analysis of 112,198 individuals from 21 countries in the PURE study.

التفاصيل البيبلوغرافية
العنوان: Association of bedtime with mortality and major cardiovascular events: an analysis of 112,198 individuals from 21 countries in the PURE study.
المؤلفون: Wang C; Medical Research and Biometrics Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China., Hu B; Medical Research and Biometrics Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China., Rangarajan S; Population Health Research Institute, McMaster University, Hamilton, ON, Canada., Bangdiwala SI; Population Health Research Institute, McMaster University, Hamilton, ON, Canada., Lear SA; Faculty of Health Sciences, Simon Fraser University, Canada., Mohan V; Dr.Mohan's Diabetes Specialities Centre, No. 6, Conran Smith Road, Gopalapuram, Chennai 600086, India., Gupta R; Eternal Heart Care Centre & Research Institute, Jawahar Circle, Jaipur 302017, India., Alhabib KF; Department of Cardiac Sciences, King Fahad Cardiac Center, College of Medicine, King Saud University, Riyadh 11472, Saudi Arabia., Soman B; Health Action By People, Navarangam Lane, Opp. Men's Hostel-3, Medical College, Trivandrum 695011, Kerala, India; Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum 695011, Kerala, India., Abat MEM; Division of Adult Medicine, Department of Medicine, Philippine General Hospital, Republic of the Philippines., Rosengren A; Sahlgrenska University Hospital/Östra Hospital, Diagnosvägen 11, SE 416 85 Göteborg, Sweden., Lanas F; Universidad de La Frontera, M Montt 112 Temuco, Chile., Avezum A; Hospital Alemão Oswaldo Cruz and UNISA, Rua 13 de Maio, 1975, São Paulo, SP, Brazil., Lopez-Jaramillo P; Masira Research Institute, Universidad de Santander (UDES), Colombia., Diaz R; Instituto Cardiovascular de Rosario, ECLA, Paraguay 160, 2000 Rosario, Argentina., Yusoff K; Universiti Teknologi MARA, Jalan Prima Selayang 7, 68100 Batu Caves, Selangor, Malaysia; UCSI University, 1 Jalan Menara Gading, Taman Connaught, 56000 Cheras, Kuala Lumpur, Malaysia., Iqbal R; Department of Community Health Sciences, The Aga Khan University, P.O. Box 3500 Stadium Road, Karachi 74800, Pakistan., Chifamba J; University of Zimbabwe, Department of Physiology, P.O.Box MP167 Harare, Zimbabwe., Yeates K; Queen's University, Department of Medicine, Kingston, Ontario, Canada., Zatońska K; Faculty of Medicine, Head of Social Medicine Department, Wroclaw Medical University, Bujwida 44 St, 50-345 Wroclaw, EU, Poland., Kruger IM; Africa Unit for Transdisciplinary Health Research (AUTHeR), North-West University, Potchefstroom Campus, Private Bag X6001, Potchefstroom, 2520, South Africa., Bahonar A; Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran., Yusufali A; Hatta Hospital, Dubai Medical College, Dubai Health Authority, Dubai, United Arab Emirates., Li W; Medical Research and Biometrics Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China. Electronic address: liwei@mrbc-nccd.com., Yusuf S; Population Health Research Institute, McMaster University, Hamilton, ON, Canada. Electronic address: Salim.Yusuf@phri.ca.
مؤلفون مشاركون: Prospective Urban Rural Epidemiology (PURE) study investigators
المصدر: Sleep medicine [Sleep Med] 2021 Apr; Vol. 80, pp. 265-272. Date of Electronic Publication: 2021 Feb 05.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100898759 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5506 (Electronic) Linking ISSN: 13899457 NLM ISO Abbreviation: Sleep Med Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam ; New York : Elsevier Science, c2000-
مواضيع طبية MeSH: Cardiovascular Diseases* , Life Style*, Humans ; Proportional Hazards Models ; Prospective Studies ; Risk Factors
مستخلص: Objectives: This study aimed to examine the association of bedtime with mortality and major cardiovascular events.
Methods: Bedtime was recorded based on self-reported habitual time of going to bed in 112,198 participants from 21 countries in the Prospective Urban Rural Epidemiology (PURE) study. Participants were prospectively followed for 9.2 years. We examined the association between bedtime and the composite outcome of all-cause mortality, non-fatal myocardial infarction, stroke and heart failure. Participants with a usual bedtime earlier than 10PM were categorized as 'earlier' sleepers and those who reported a bedtime after midnight as 'later' sleepers. Cox frailty models were applied with random intercepts to account for the clustering within centers.
Results: A total of 5633 deaths and 5346 major cardiovascular events were reported. A U-shaped association was observed between bedtime and the composite outcome. Using those going to bed between 10PM and midnight as the reference group, after adjustment for age and sex, both earlier and later sleepers had a higher risk of the composite outcome (HR of 1.29 [1.22, 1.35] and 1.11 [1.03, 1.20], respectively). In the fully adjusted model where demographic factors, lifestyle behaviors (including total sleep duration) and history of diseases were included, results were greatly attenuated, but the estimates indicated modestly higher risks in both earlier (HR of 1.09 [1.03-1.16]) and later sleepers (HR of 1.10 [1.02-1.20]).
Conclusion: Early (10 PM or earlier) or late (Midnight or later) bedtimes may be an indicator or risk factor of adverse health outcomes.
(Copyright © 2021. Published by Elsevier B.V.)
التعليقات: Erratum in: Sleep Med. 2022 Apr;92:108. (PMID: 34996707)
فهرسة مساهمة: Keywords: Bedtime; Cardiovascular events; Mortality
تواريخ الأحداث: Date Created: 20210220 Date Completed: 20210705 Latest Revision: 20220108
رمز التحديث: 20221213
DOI: 10.1016/j.sleep.2021.01.057
PMID: 33610073
قاعدة البيانات: MEDLINE
الوصف
تدمد:1878-5506
DOI:10.1016/j.sleep.2021.01.057