دورية أكاديمية
Hydrocortisone administration for reducing post-traumatic stress symptoms: A systematic review and meta-analysis.
| العنوان: | Hydrocortisone administration for reducing post-traumatic stress symptoms: A systematic review and meta-analysis. |
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| المؤلفون: | Kothgassner OD; Department of Child and Adolescent Psychiatry, Medical University of Vienna, Vienna, Austria. Electronic address: oswald.kothgassner@meduniwien.ac.at., Pellegrini M; Department of Developmental and Educational Psychology, Faculty of Psychology, University of Vienna, Vienna, Austria., Goreis A; Department of Clinical and Health Psychology, Faculty of Psychology, University of Vienna, Vienna, Austria; Outpatient Unit for Research, Teaching and Practice, Faculty of Psychology, University of Vienna, Vienna, Austria., Giordano V; Department of Paediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria., Edobor J; Department of Paediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria., Fischer S; Institute of Psychology, Clinical Psychology and Psychotherapy, University of Zurich, Zurich, Switzerland., Plener PL; Department of Child and Adolescent Psychiatry, Medical University of Vienna, Vienna, Austria; Department of Child, and Adolescent Psychiatry and Psychotherapy, University of Ulm, Ulm, Germany., Huscsava MM; Department of Child and Adolescent Psychiatry, Medical University of Vienna, Vienna, Austria. |
| المصدر: | Psychoneuroendocrinology [Psychoneuroendocrinology] 2021 Apr; Vol. 126, pp. 105168. Date of Electronic Publication: 2021 Feb 16. |
| نوع المنشور: | Journal Article; Meta-Analysis; Systematic Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Pergamon Press Country of Publication: England NLM ID: 7612148 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3360 (Electronic) Linking ISSN: 03064530 NLM ISO Abbreviation: Psychoneuroendocrinology Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford, Elmsford, N. Y., Pergamon Press. |
| مواضيع طبية MeSH: | Hydrocortisone*/administration & dosage , Stress Disorders, Post-Traumatic*/prevention & control, Humans ; Randomized Controlled Trials as Topic ; Treatment Outcome |
| مستخلص: | Background: Post-traumatic stress disorder (PTSD) is a debilitating disorder that is often accompanied by alterations in the hypothalamic-pituitary (HPA) axis. While there is abundant evidence for the efficacy of psychological therapies in reducing post-traumatic stress symptoms, barely anything is known about pharmacological interventions. Given the role of the HPA axis in the pathophysiology of PTSD, the aim of this study was to provide the first meta-analysis of Hydrocortisone as a potential treatment for this condition. Method: A systematic review of randomized-controlled trials (RCTs) was conducted to investigate the efficacy of hydrocortisone in the prevention and curative treatment of post-traumatic stress symptoms. This study was pre-registered with the OSF (doi:10.17605/OSF.IO/GJAZF). Findings: Eight studies (9 effect sizes) covering 362 participants met our inclusion criteria. We found that Hydrocortisone as compared to placebo significantly reduced PTSD symptoms (d = 0.96, 95% Cl 0.22-1.69 p = 0.011) and PTSD incidence (logRR = 0.85, 95% CI 1.12-1.59, p = 0.023). Subgroup analyses revealed a significant effect of Hydrocortisone when it was administered in a preventative context (d = 1.50; 95%CI 0.30-2.69, p = 0.014), but not when it was administered in a curative context (d = 0.28; 95%CI -0.11 to 0.66, p = 0.161). Conclusion: Hydrocortisone appears to be a promising and efficient low-cost medication for the prevention of PTSD. However, the small number of included studies and their limited methodological quality emphasize the need for further rigorous studies in this field. (Copyright © 2021 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Cortisol; Hydrocortisone; PTSD; Traumatic stress; Treatment augmentation |
| المشرفين على المادة: | WI4X0X7BPJ (Hydrocortisone) |
| تواريخ الأحداث: | Date Created: 20210224 Date Completed: 20220308 Latest Revision: 20220308 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.psyneuen.2021.105168 |
| PMID: | 33626392 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1873-3360 |
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| DOI: | 10.1016/j.psyneuen.2021.105168 |