دورية أكاديمية
Changes in the topology of DNA replication intermediates: Important discrepancies between in vitro and in vivo.
العنوان: | Changes in the topology of DNA replication intermediates: Important discrepancies between in vitro and in vivo. |
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المؤلفون: | Schvartzman JB; Department of Cellular and Molecular Biology, Centro de Investigaciones Biológicas (CSIC), Madrid, Spain., Martínez V; Directorate of Research and Postgraduate Studies, Polytechnic School, National University of Asunción, P, San Lorenzo, Paraguay., Hernández P; Department of Cellular and Molecular Biology, Centro de Investigaciones Biológicas (CSIC), Madrid, Spain., Krimer DB; Department of Cellular and Molecular Biology, Centro de Investigaciones Biológicas (CSIC), Madrid, Spain., Fernández-Nestosa MJ; Directorate of Research and Postgraduate Studies, Polytechnic School, National University of Asunción, P, San Lorenzo, Paraguay. |
المصدر: | BioEssays : news and reviews in molecular, cellular and developmental biology [Bioessays] 2021 May; Vol. 43 (5), pp. e2000309. Date of Electronic Publication: 2021 Feb 25. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Wiley Country of Publication: United States NLM ID: 8510851 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-1878 (Electronic) Linking ISSN: 02659247 NLM ISO Abbreviation: Bioessays Subsets: MEDLINE |
أسماء مطبوعة: | Publication: <2005->: Hoboken, N.J. : Wiley Original Publication: Cambridge, UK : Published for the ICSU Press by Cambridge University Press, c1984- |
مواضيع طبية MeSH: | DNA Replication* , DNA Topoisomerase IV*/genetics , DNA Topoisomerase IV*/metabolism, DNA/genetics ; Nucleic Acid Conformation |
مستخلص: | The topology of DNA duplexes changes during replication and also after deproteinization in vitro. Here we describe these changes and then discuss for the first time how the distribution of superhelical stress affects the DNA topology of replication intermediates, taking into account the progression of replication forks. The high processivity of Topo IV to relax the left-handed (+) supercoiling that transiently accumulates ahead of the forks is not essential, since DNA gyrase and swiveling of the forks cooperate with Topo IV to accomplish this task in vivo. We conclude that despite Topo IV has a lower processivity to unlink the right-handed (+) crossings of pre-catenanes and fully replicated catenanes, this is indeed its main role in vivo. This would explain why in the absence of Topo IV replication goes-on, but fully replicated sister duplexes remain heavily catenated. (© 2021 The Authors. BioEssays published by Wiley Periodicals LLC.) |
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فهرسة مساهمة: | Keywords: DNA chirality; DNA topology; catenation; pre-catenation; replication; supercoiling |
المشرفين على المادة: | 9007-49-2 (DNA) EC 5.99.1.- (DNA Topoisomerase IV) |
تواريخ الأحداث: | Date Created: 20210225 Date Completed: 20210923 Latest Revision: 20210923 |
رمز التحديث: | 20231215 |
DOI: | 10.1002/bies.202000309 |
PMID: | 33629756 |
قاعدة البيانات: | MEDLINE |
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