دورية أكاديمية
Mechanochemical control of epidermal stem cell divisions by B-plexins.
| العنوان: | Mechanochemical control of epidermal stem cell divisions by B-plexins. |
|---|---|
| المؤلفون: | Jiang C; Institute of Pharmacology, University of Marburg, Marburg, Germany.; Department of Pharmacology, Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany., Javed A; Helsinki Institute of Life Science, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland., Kaiser L; Institute of Pharmacology, University of Marburg, Marburg, Germany., Nava MM; Helsinki Institute of Life Science, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland., Xu R; Institute of Pharmacology, University of Marburg, Marburg, Germany.; Department of Pharmacology, Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany., Brandt DT; Institute of Pharmacology, University of Marburg, Marburg, Germany., Zhao D; Institute of Pharmacology, University of Marburg, Marburg, Germany., Mayer B; Biochemistry, Faculty of Chemistry, and Center for Synthetic Microbiology (synmikro), University of Marburg, Marburg, Germany., Fernández-Baldovinos J; Institute of Pharmacology, University of Marburg, Marburg, Germany., Zhou L; Institute of Pharmacology, University of Marburg, Marburg, Germany.; Department of Diabetes and Endocrinology, Affiliated Hospital of Southwest Medical University, Luzhou, China., Höß C; Institute of Pharmacology, University of Marburg, Marburg, Germany., Sawmynaden K; LifeArc, Stevenage, UK., Oleksy A; LifeArc, Stevenage, UK., Matthews D; LifeArc, Stevenage, UK., Weinstein LS; Metabolic Diseases Branch, NIDDK, NIH, Bethesda, USA., Hahn H; Institute of Human Genetics, University Medical Center Göttingen, Göttingen, Germany., Gröne HJ; Institute of Pharmacology, University of Marburg, Marburg, Germany., Graumann PL; Biochemistry, Faculty of Chemistry, and Center for Synthetic Microbiology (synmikro), University of Marburg, Marburg, Germany., Niessen CM; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany., Offermanns S; Department of Pharmacology, Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany.; Medical Faculty, University of Frankfurt, Frankfurt, Germany., Wickström SA; Helsinki Institute of Life Science, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.; Wihuri Research Institute, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.; Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Max-Planck-Institute for Biology of Ageing, Cologne, Germany., Worzfeld T; Institute of Pharmacology, University of Marburg, Marburg, Germany. worzfeld@uni-marburg.de.; Department of Pharmacology, Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany. worzfeld@uni-marburg.de. |
| المصدر: | Nature communications [Nat Commun] 2021 Feb 26; Vol. 12 (1), pp. 1308. Date of Electronic Publication: 2021 Feb 26. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [London] : Nature Pub. Group |
| مواضيع طبية MeSH: | Cell Adhesion Molecules/*metabolism , Cell Division/*physiology , Epidermal Cells/*metabolism , Nerve Tissue Proteins/*metabolism , Receptors, Cell Surface/*metabolism , Stem Cells/*metabolism, Animals ; Carcinoma, Basal Cell/pathology ; Carrier Proteins/metabolism ; Cell Adhesion ; Cell Proliferation ; Embryonic Development/physiology ; Epithelial Cells/metabolism ; Epithelium/metabolism ; Female ; Intercellular Junctions ; Keratinocytes ; Mice ; Mitosis ; Morphogenesis ; Organogenesis |
| مستخلص: | The precise spatiotemporal control of cell proliferation is key to the morphogenesis of epithelial tissues. Epithelial cell divisions lead to tissue crowding and local changes in force distribution, which in turn suppress the rate of cell divisions. However, the molecular mechanisms underlying this mechanical feedback are largely unclear. Here, we identify a critical requirement of B-plexin transmembrane receptors in the response to crowding-induced mechanical forces during embryonic skin development. Epidermal stem cells lacking B-plexins fail to sense mechanical compression, resulting in disinhibition of the transcriptional coactivator YAP, hyperproliferation, and tissue overgrowth. Mechanistically, we show that B-plexins mediate mechanoresponses to crowding through stabilization of adhesive cell junctions and lowering of cortical stiffness. Finally, we provide evidence that the B-plexin-dependent mechanochemical feedback is also pathophysiologically relevant to limit tumor growth in basal cell carcinoma, the most common type of skin cancer. Our data define a central role of B-plexins in mechanosensation to couple cell density and cell division in development and disease. |
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| المشرفين على المادة: | 0 (Carrier Proteins) 0 (Cell Adhesion Molecules) 0 (Nerve Tissue Proteins) 0 (PLXNB1 protein, human) 0 (PLXNB2 protein, human) 0 (Receptors, Cell Surface) 0 (plexin) |
| تواريخ الأحداث: | Date Created: 20210227 Date Completed: 20210315 Latest Revision: 20230129 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC7910479 |
| DOI: | 10.1038/s41467-021-21513-9 |
| PMID: | 33637728 |
| قاعدة البيانات: | MEDLINE |
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