دورية أكاديمية
Systematic review and meta-analysis of the effect of pertussis vaccine in pregnancy on the risk of chorioamnionitis, non-pertussis infectious diseases and other adverse pregnancy outcomes.
| العنوان: | Systematic review and meta-analysis of the effect of pertussis vaccine in pregnancy on the risk of chorioamnionitis, non-pertussis infectious diseases and other adverse pregnancy outcomes. |
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| المؤلفون: | Andersen AR; Faculty of Health Sciences, University of Southern Denmark, Denmark., Kolmos SK; Faculty of Health Sciences, University of Southern Denmark, Denmark., Flanagan KL; Tasmanian Vaccine Trial Centre, Launceston General Hospital, Launceston, TAS, Australia; School of Medicine, Faculty of Health Sciences, University of Tasmania, Launceston, TAS, Australia; School of Health and Biomedical Science, RMIT University, Melbourne, VIC, Australia; Department of Immunology and Pathology, Monash University, Melbourne, VIC, Australia., Benn CS; OPEN, Odense Patient Data Explorative Network, Institute of Clinical Research, Odense University Hospital/University of Southern Denmark, Denmark; Danish Institute of Advanced Science, University of Southern Denmark, Denmark. Electronic address: cbenn@health.sdu.dk. |
| المصدر: | Vaccine [Vaccine] 2022 Mar 08; Vol. 40 (11), pp. 1572-1582. Date of Electronic Publication: 2021 Feb 25. |
| نوع المنشور: | Journal Article; Meta-Analysis; Systematic Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8406899 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2518 (Electronic) Linking ISSN: 0264410X NLM ISO Abbreviation: Vaccine Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam, The Netherlands : Elsevier Science Original Publication: [Guildford, Surrey, UK] : Butterworths, [c1983- |
| مواضيع طبية MeSH: | Chorioamnionitis*/epidemiology , Communicable Diseases*/complications , Whooping Cough*/complications , Whooping Cough*/epidemiology , Whooping Cough*/prevention & control, Female ; Humans ; Infant ; Pertussis Vaccine/adverse effects ; Pregnancy ; Pregnancy Outcome |
| مستخلص: | Background: Several countries have introduced maternal immunisation with pertussis vaccine to provide protection against pertussis in early infancy. There is increasing interest in non-specific effects of vaccines including that non-live vaccines may enhance susceptibility to non-targeted infections in females. Some studies have shown increased risk of chorioamnionitis among women receiving pertussis vaccine during pregnancy. We aimed to conduct a systematic review and meta-analysis of the effect of maternal pertussis immunisation on the risk of chorioamnionitis, as well as the secondary outcomes of non-pertussis infections in women, non-pertussis infections in infants, spontaneous abortion or stillbirth, maternal death and infant death. Methods: We searched PubMed and Embase for articles published until January 14, 2021. We screened articles for eligibility and extracted data using Covidence. Quality was assessed using Cochrane RoB tool and Newcastle-Ottawa Scale. Data were imported into RevMan for pooling and conduction of a meta-analysis stratified by study type. Outcomes are presented as risk ratios. Results: We identified 13 observational studies and six randomized controlled trials eligible for inclusion. We pooled data on chorioamnionitis from six observational studies and found maternal pertussis vaccine (mostly compared with other maternal immunizations with non-live vaccines) to be associated with an increased risk among the pertussis vaccinated women, RR = 1.27 [CI 95%: 1.14-1.42]. We found no difference in the analysis of our secondary outcomes of non-pertussis infections, spontaneous abortion or stillbirth and death. Conclusion: We found an increased risk of chorioamnionitis among women who received pertussis vaccine in pregnancy. The large number of women receiving pertussis vaccine during pregnancy, as well as the growing evidence of non-live vaccines causing increased susceptibility to infections, indicates a need for further randomised trials to assess potential adverse effects of maternal immunisation with pertussis-containing vaccines. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2021 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Chorioamnionitis; Maternal pertussis vaccination; Non-specific effects of vaccines; Pregnancy; Tdap; Vaccine safety |
| المشرفين على المادة: | 0 (Pertussis Vaccine) |
| تواريخ الأحداث: | Date Created: 20210301 Date Completed: 20220310 Latest Revision: 20220311 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.vaccine.2021.02.018 |
| PMID: | 33642162 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1873-2518 |
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| DOI: | 10.1016/j.vaccine.2021.02.018 |