دورية أكاديمية
أعرض في EDS

Low-Temperature Argon Plasma Regulates Skin Moisturizing and Melanogenesis-Regulating Markers through Yes-Associated Protein.

التفاصيل البيبلوغرافية
العنوان: Low-Temperature Argon Plasma Regulates Skin Moisturizing and Melanogenesis-Regulating Markers through Yes-Associated Protein.
المؤلفون: Kim HY; Department of Dermato-Immunology, College of Medicine, Catholic University of Korea, Seoul 06591, Korea., Agrahari G; Department of Dermato-Immunology, College of Medicine, Catholic University of Korea, Seoul 06591, Korea., Lee MJ; Department of Dermato-Immunology, College of Medicine, Catholic University of Korea, Seoul 06591, Korea., Tak LJ; Department of Dermato-Immunology, College of Medicine, Catholic University of Korea, Seoul 06591, Korea., Ham WK; Department of Dermato-Immunology, College of Medicine, Catholic University of Korea, Seoul 06591, Korea., Kim TY; Department of Dermato-Immunology, College of Medicine, Catholic University of Korea, Seoul 06591, Korea.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2021 Feb 14; Vol. 22 (4). Date of Electronic Publication: 2021 Feb 14.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Adaptor Proteins, Signal Transducing/*metabolism , Argon/*pharmacology , Melanins/*metabolism , Plasma Gases/*pharmacology , Skin/*drug effects , Transcription Factors/*metabolism, Animals ; Cell Line ; Cell Line, Tumor ; Cells, Cultured ; Collagen Type I, alpha 1 Chain ; Filaggrin Proteins ; Humans ; Keratinocytes/cytology ; Keratinocytes/drug effects ; Keratinocytes/metabolism ; Melanocytes/cytology ; Melanocytes/drug effects ; Melanocytes/metabolism ; Mice ; Receptor, Melanocortin, Type 1/metabolism ; Skin/metabolism ; Skin Aging/drug effects ; Temperature ; YAP-Signaling Proteins ; alpha-MSH/metabolism
مستخلص: Extensive water loss and melanin hyperproduction can cause various skin disorders. Low-temperature argon plasma (LTAP) has shown the possibility of being used for the treatment of various skin diseases, such as atopic dermatitis and skin cancer. However, the role of LTAP in regulating skin moisturizing and melanogenesis has not been investigated. In this study, we aimed to determine the effect of LTAP on yes-associated protein (YAP), a major transcriptional coactivator in the Hippo signaling pathway that is involved in skin moisturizing and melanogenesis-regulating markers. In normal human epidermal keratinocytes (NHEKs), the human epidermal keratinocyte line HaCaT, and human dermal fibroblasts (HDFs), we found that LTAP exhibited increased expression levels of YAP protein. In addition, the expression levels of filaggrin (FLG), which is involved in natural moisturizing factors (NMFs), and hyaluronic acid synthase (HAS), transglutaminase (TGM), and involucrin (IVL), which regulate skin barrier and moisturizing, were also increased after exposure to LTAP. Furthermore, collagen type I alpha 1 and type III alpha 1 (COL1A1, COL3A1) were increased after LTAP exposure, but the expression level of matrix metalloproteinase-3 (MMP-3) was reduced. Moreover, LTAP was found to suppress alpha-melanocyte stimulating hormone (α-MSH)-induced melanogenesis in murine melanoma B16F10 cells and normal human melanocytes (NHEMs). LTAP regulates melanogenesis of the melanocytes through decreased YAP pathway activation in a melanocortin 1 receptor (MC1R)-dependent manner. Taken together, our data show that LTAP regulates skin moisturizing and melanogenesis through modulation of the YAP pathway, and the effect of LTAP on the expression level of YAP varies from cell to cell. Thus, LTAP might be developed as a treatment method to improve the skin barrier, moisture content, and wrinkle formation, and to reduce melanin generation.
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معلومات مُعتمدة: 2016M3A9B6903020 National Research Foundation of Korea
فهرسة مساهمة: Keywords: low-temperature argon plasma; melanogenesis; melanoma; skin barrier; skin moisturizing; yes-associated protein
المشرفين على المادة: 0 (Adaptor Proteins, Signal Transducing)
0 (COL1A1 protein, human)
0 (Collagen Type I, alpha 1 Chain)
0 (FLG protein, human)
0 (Filaggrin Proteins)
0 (Melanins)
0 (Plasma Gases)
0 (Receptor, Melanocortin, Type 1)
0 (Transcription Factors)
0 (YAP-Signaling Proteins)
0 (YAP1 protein, human)
581-05-5 (alpha-MSH)
67XQY1V3KH (Argon)
تواريخ الأحداث: Date Created: 20210306 Date Completed: 20210419 Latest Revision: 20211204
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC7918577
DOI: 10.3390/ijms22041895
PMID: 33672928
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms22041895