دورية أكاديمية
Low-Temperature Argon Plasma Regulates Skin Moisturizing and Melanogenesis-Regulating Markers through Yes-Associated Protein.
العنوان: | Low-Temperature Argon Plasma Regulates Skin Moisturizing and Melanogenesis-Regulating Markers through Yes-Associated Protein. |
---|---|
المؤلفون: | Kim HY; Department of Dermato-Immunology, College of Medicine, Catholic University of Korea, Seoul 06591, Korea., Agrahari G; Department of Dermato-Immunology, College of Medicine, Catholic University of Korea, Seoul 06591, Korea., Lee MJ; Department of Dermato-Immunology, College of Medicine, Catholic University of Korea, Seoul 06591, Korea., Tak LJ; Department of Dermato-Immunology, College of Medicine, Catholic University of Korea, Seoul 06591, Korea., Ham WK; Department of Dermato-Immunology, College of Medicine, Catholic University of Korea, Seoul 06591, Korea., Kim TY; Department of Dermato-Immunology, College of Medicine, Catholic University of Korea, Seoul 06591, Korea. |
المصدر: | International journal of molecular sciences [Int J Mol Sci] 2021 Feb 14; Vol. 22 (4). Date of Electronic Publication: 2021 Feb 14. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI, [2000- |
مواضيع طبية MeSH: | Adaptor Proteins, Signal Transducing/*metabolism , Argon/*pharmacology , Melanins/*metabolism , Plasma Gases/*pharmacology , Skin/*drug effects , Transcription Factors/*metabolism, Animals ; Cell Line ; Cell Line, Tumor ; Cells, Cultured ; Collagen Type I, alpha 1 Chain ; Filaggrin Proteins ; Humans ; Keratinocytes/cytology ; Keratinocytes/drug effects ; Keratinocytes/metabolism ; Melanocytes/cytology ; Melanocytes/drug effects ; Melanocytes/metabolism ; Mice ; Receptor, Melanocortin, Type 1/metabolism ; Skin/metabolism ; Skin Aging/drug effects ; Temperature ; YAP-Signaling Proteins ; alpha-MSH/metabolism |
مستخلص: | Extensive water loss and melanin hyperproduction can cause various skin disorders. Low-temperature argon plasma (LTAP) has shown the possibility of being used for the treatment of various skin diseases, such as atopic dermatitis and skin cancer. However, the role of LTAP in regulating skin moisturizing and melanogenesis has not been investigated. In this study, we aimed to determine the effect of LTAP on yes-associated protein (YAP), a major transcriptional coactivator in the Hippo signaling pathway that is involved in skin moisturizing and melanogenesis-regulating markers. In normal human epidermal keratinocytes (NHEKs), the human epidermal keratinocyte line HaCaT, and human dermal fibroblasts (HDFs), we found that LTAP exhibited increased expression levels of YAP protein. In addition, the expression levels of filaggrin (FLG), which is involved in natural moisturizing factors (NMFs), and hyaluronic acid synthase (HAS), transglutaminase (TGM), and involucrin (IVL), which regulate skin barrier and moisturizing, were also increased after exposure to LTAP. Furthermore, collagen type I alpha 1 and type III alpha 1 (COL1A1, COL3A1) were increased after LTAP exposure, but the expression level of matrix metalloproteinase-3 (MMP-3) was reduced. Moreover, LTAP was found to suppress alpha-melanocyte stimulating hormone (α-MSH)-induced melanogenesis in murine melanoma B16F10 cells and normal human melanocytes (NHEMs). LTAP regulates melanogenesis of the melanocytes through decreased YAP pathway activation in a melanocortin 1 receptor (MC1R)-dependent manner. Taken together, our data show that LTAP regulates skin moisturizing and melanogenesis through modulation of the YAP pathway, and the effect of LTAP on the expression level of YAP varies from cell to cell. Thus, LTAP might be developed as a treatment method to improve the skin barrier, moisture content, and wrinkle formation, and to reduce melanin generation. |
References: | J Photochem Photobiol B. 2017 Feb;167:1-6. (PMID: 28039784) Arch Dermatol. 2002 Nov;138(11):1462-70. (PMID: 12437452) Arch Dermatol Res. 2014 Sep;306(7):635-43. (PMID: 24728827) J Hepatol. 2014 Nov;61(5):1088-96. (PMID: 25010260) Arch Dermatol Res. 2013 Mar;305(2):133-40. (PMID: 22773133) Adv Wound Care (New Rochelle). 2013 Jun;2(5):215-224. (PMID: 24527344) BMC Complement Altern Med. 2017 Jun 27;17(1):340. (PMID: 28655324) Nat Cell Biol. 2011 Aug 01;13(8):877-83. (PMID: 21808241) Life Sci. 2018 Oct 1;210:201-208. (PMID: 30145155) Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1789-93. (PMID: 7878059) J Invest Dermatol. 2017 Mar;137(3):650-659. (PMID: 27840235) Bioessays. 2016 Jul;38(7):644-53. (PMID: 27173018) Br J Nutr. 2012 Nov 28;108(10):1726-35. (PMID: 22244094) Sci Rep. 2017 Nov 14;7(1):15528. (PMID: 29138479) J Invest Dermatol. 2014 Jan;134(1):123-132. (PMID: 23897276) J Invest Dermatol. 2015 Jun;135(6):1621-1628. (PMID: 25668240) Int J Mol Sci. 2018 Sep 08;19(9):. (PMID: 30205559) Hum Mol Genet. 2000 Aug 12;9(13):1907-17. (PMID: 10942418) J Invest Dermatol. 1989 Mar;92(3):326-32. (PMID: 2465358) J Cell Sci. 1999 Dec;112 ( Pt 24):4569-79. (PMID: 10574706) Cancer Sci. 2017 Mar;108(3):478-487. (PMID: 28002618) Mech Ageing Dev. 2002 Apr;123(7):801-10. (PMID: 11869737) Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2270-5. (PMID: 21262812) J Am Acad Dermatol. 2001 May;44(5):837-46. (PMID: 11312434) Drug Discov Today Dis Mech. 2008;5(2):e189-e199. (PMID: 19578486) Dermatol Nurs. 2008 Jun;20(3):177-83; quiz 184. (PMID: 18649702) J Exp Clin Cancer Res. 2016 Sep 06;35(1):134. (PMID: 27599610) Nat Genet. 1998 Mar;18(3):283-6. (PMID: 9500554) An Bras Dermatol. 2013 Jan-Feb;88(1):76-83. (PMID: 23539007) Biomolecules. 2020 Jul 08;10(7):. (PMID: 32650505) J Immunother. 1997 Jan;20(1):60-4. (PMID: 9101414) Am J Pathol. 2012 Sep;181(3):969-77. (PMID: 22796440) Oncogene. 2018 Jun;37(23):3166-3182. (PMID: 29545604) Int J Mol Sci. 2019 Dec 05;20(24):. (PMID: 31817532) J Cancer. 2019 Jan 1;10(1):1-10. (PMID: 30662519) Nat Rev Mol Cell Biol. 2005 Apr;6(4):328-40. (PMID: 15803139) Pigment Cell Melanoma Res. 2015 Jul;28(4):390-406. (PMID: 25818589) Am J Cancer Res. 2016 Dec 01;6(12):2816-2830. (PMID: 28042502) Cell. 2011 Mar 4;144(5):782-95. (PMID: 21376238) Cancer Cell. 2008 Mar;13(3):188-92. (PMID: 18328423) Pigment Cell Res. 1989 Nov-Dec;2(6):510-8. (PMID: 2557606) Dermatol Ther. 2004;17 Suppl 1:43-8. (PMID: 14728698) Oxid Med Cell Longev. 2019 Dec 22;2019:9827519. (PMID: 31949887) |
معلومات مُعتمدة: | 2016M3A9B6903020 National Research Foundation of Korea |
فهرسة مساهمة: | Keywords: low-temperature argon plasma; melanogenesis; melanoma; skin barrier; skin moisturizing; yes-associated protein |
المشرفين على المادة: | 0 (Adaptor Proteins, Signal Transducing) 0 (COL1A1 protein, human) 0 (Collagen Type I, alpha 1 Chain) 0 (FLG protein, human) 0 (Filaggrin Proteins) 0 (Melanins) 0 (Plasma Gases) 0 (Receptor, Melanocortin, Type 1) 0 (Transcription Factors) 0 (YAP-Signaling Proteins) 0 (YAP1 protein, human) 581-05-5 (alpha-MSH) 67XQY1V3KH (Argon) |
تواريخ الأحداث: | Date Created: 20210306 Date Completed: 20210419 Latest Revision: 20211204 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC7918577 |
DOI: | 10.3390/ijms22041895 |
PMID: | 33672928 |
قاعدة البيانات: | MEDLINE |
كن أول من يترك تعليقا!