دورية أكاديمية
Reactivity of skin microcirculation as a biomarker of cardiovascular events. Pilot study.
| العنوان: | Reactivity of skin microcirculation as a biomarker of cardiovascular events. Pilot study. |
|---|---|
| المؤلفون: | Glazkova PA; Moscow Regional Research and Clinical Institute ('MONIKI'), Moscow, Russian Federation., Kulikov DA; Moscow Regional Research and Clinical Institute ('MONIKI'), Moscow, Russian Federation.; Moscow Region State University, Mytishchi, Russian Federation., Glazkov AA; Moscow Regional Research and Clinical Institute ('MONIKI'), Moscow, Russian Federation., Terpigorev SA; Moscow Regional Research and Clinical Institute ('MONIKI'), Moscow, Russian Federation., Rogatkin DA; Moscow Regional Research and Clinical Institute ('MONIKI'), Moscow, Russian Federation., Shekhyan GG; Moscow Regional Research and Clinical Institute ('MONIKI'), Moscow, Russian Federation., Krasulina KA; Moscow Regional Research and Clinical Institute ('MONIKI'), Moscow, Russian Federation., Kulikov AV; Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russian Federation., Makmatov-Rys MB; Moscow Regional Research and Clinical Institute ('MONIKI'), Moscow, Russian Federation., Paleev FN; National medical research center of cardiology of the Ministry of healthcare of the Russian Federation, Moscow, Russian Federation. |
| المصدر: | Clinical hemorheology and microcirculation [Clin Hemorheol Microcirc] 2021; Vol. 78 (3), pp. 247-257. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Ios Press Country of Publication: Netherlands NLM ID: 9709206 Publication Model: Print Cited Medium: Internet ISSN: 1875-8622 (Electronic) Linking ISSN: 13860291 NLM ISO Abbreviation: Clin Hemorheol Microcirc Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Ios Press Original Publication: Amsterdam ; Washington, DC : IOS Press, c1997- |
| مواضيع طبية MeSH: | Cardiovascular Diseases* , Skin*, Biomarkers ; Humans ; Laser-Doppler Flowmetry ; Microcirculation ; Pilot Projects |
| مستخلص: | Background: The role of microcirculatory disorders is progressively being accepted in the pathogenesis of cardiovascular diseases. Objective: The purpose of current study is to assess whether we can consider skin microcirculation disorders as a biomarker of cardiovascular events. Methods: Group 1 consisted of healthy volunteers (n = 31); group 2 (n = 42) consisted of patients with diseases that increase the risk of cardiovascular events; group 3 (n = 39) included patients with the history of cardiovascular events. Skin microcirculation measurement was performed using laser Doppler flowmetry during the heating test. Results: LDF parameters reflecting the rapid response of microcirculation to heating ("Slope 120 s" and "Slope 180 s") significantly differed in three groups (p < 0.05). A decrease in the "Slope 180 s" parameter less than 0.5 PU/s is associated with cardiovascular events (sensitivity 69.2%, specificity 66.7%; the area under the ROC curve, 0.667; 95% confidence interval [CI], 0.545-0.788, p = 0.01). Multivariable logistic regression analysis revealed that "Slope 180 s≤0.5 PU/s" was significantly related to cardiovascular events (adjusted odds ratio = 3.9, p = 0.019, CI 95% 1.2-12). Conclusions: Reduced reactivity of the skin microcirculation may be useful as a biomarker of severe damage to the cardiovascular system and is promising as a risk factor for cardiovascular events. |
| فهرسة مساهمة: | Keywords: Cardiovascular diseases; diabetes mellitus; hypertension; laser-Doppler flowmetry; microcirculation; risk factors; skin |
| المشرفين على المادة: | 0 (Biomarkers) |
| تواريخ الأحداث: | Date Created: 20210308 Date Completed: 20211019 Latest Revision: 20211019 |
| رمز التحديث: | 20231215 |
| DOI: | 10.3233/CH-201016 |
| PMID: | 33682698 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1875-8622 |
|---|---|
| DOI: | 10.3233/CH-201016 |