تقرير
Loss of Tmem106b leads to cerebellum Purkinje cell death and motor deficits.
| العنوان: | Loss of Tmem106b leads to cerebellum Purkinje cell death and motor deficits. |
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| المؤلفون: | Rademakers R; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.; Applied and Translational Neurogenomics, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium., Nicholson AM; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Ren Y; Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL, USA., Koga S; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Nguyen HP; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Brooks M; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Qiao W; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Quicksall ZS; Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL, USA., Matchett B; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Perkerson RB; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Kurti A; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Castanedes-Casey M; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Phillips V; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Librero AL; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Fernandez De Castro CH; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Baker MC; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Roemer SF; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Murray ME; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Asmann Y; Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL, USA., Fryer JD; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Bu G; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Dickson DW; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Zhou X; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China. |
| المصدر: | Brain pathology (Zurich, Switzerland) [Brain Pathol] 2021 May; Vol. 31 (3), pp. e12945. Date of Electronic Publication: 2021 Mar 11. |
| نوع المنشور: | Letter; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Comment |
| اللغة: | English |
| بيانات الدورية: | Publisher: International Society of Neuropathology Country of Publication: Switzerland NLM ID: 9216781 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1750-3639 (Electronic) Linking ISSN: 10156305 NLM ISO Abbreviation: Brain Pathol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Zürich, Switzerland : International Society of Neuropathology, [1990- |
| مواضيع طبية MeSH: | Purkinje Cells*, Animals ; Disease Models, Animal ; Mice |
| مستخلص: | TMEM106B has been recently implicated in multiple neurodegenerative diseases. Here, Rademakers et al. report a late-onset cerebellar Purkinje cell loss and progressive decline in motor function and gait deficits in a conventional Tmem106b-/- mouse model. By using high-power microscopy and bulk RNA sequencing, the authors further identify lysosomal and immune dysfunction as potential underlying mechanisms of the Purkinje cell loss. (© 2021 The Authors. Brain Pathology published by John Wiley & Sons Ltd on behalf of International Society of Neuropathology.) |
| التعليقات: | Comment on: Brain Pathol. 2021 Mar;31(2):223-238. (PMID: 33016371) |
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| معلومات مُعتمدة: | P30 AG062677 United States AG NIA NIH HHS; R35 NS097261 United States NS NINDS NIH HHS |
| تواريخ الأحداث: | Date Created: 20210312 Date Completed: 20211014 Latest Revision: 20211014 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC8412084 |
| DOI: | 10.1111/bpa.12945 |
| PMID: | 33709463 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1750-3639 |
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| DOI: | 10.1111/bpa.12945 |