دورية أكاديمية
أعرض في EDS

The chemical compound 'Heatin' stimulates hypocotyl elongation and interferes with the Arabidopsis NIT1-subfamily of nitrilases.

التفاصيل البيبلوغرافية
العنوان: The chemical compound 'Heatin' stimulates hypocotyl elongation and interferes with the Arabidopsis NIT1-subfamily of nitrilases.
المؤلفون: van der Woude L; Molecular Plant Physiology, Institute of Environmental Biology, Utrecht University, Padualaan 8, Utrecht, 3584 CH, the Netherlands., Piotrowski M; Department of Molecular Genetics and Physiology of Plants, Faculty of Biology and Biotechnology, Universitätsstraße 150, Bochum, 44801, Germany., Klaasse G; Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, University Utrecht, Universiteitsweg 99, Utrecht, 3584 CG, the Netherlands., Paulus JK; Plant Chemetics Laboratory, Department of Plant Sciences, University of Oxford, South Parks Road, Oxford, OX1 3RB, UK., Krahn D; Plant Chemetics Laboratory, Department of Plant Sciences, University of Oxford, South Parks Road, Oxford, OX1 3RB, UK., Ninck S; Chemische Biologie, Zentrum für Medizinische Biotechnologie, Fakultät für Biologie, Universität Duisburg-Essen, Universitätsstr. 2, Essen, 45117, Germany., Kaschani F; Chemische Biologie, Zentrum für Medizinische Biotechnologie, Fakultät für Biologie, Universität Duisburg-Essen, Universitätsstr. 2, Essen, 45117, Germany., Kaiser M; Chemische Biologie, Zentrum für Medizinische Biotechnologie, Fakultät für Biologie, Universität Duisburg-Essen, Universitätsstr. 2, Essen, 45117, Germany., Novák O; Umeå Plant Science Centre, Department of Forest Genetics and Plant Physiology, Swedish University of Agricultural Sciences, Umea, SE-901 83, Sweden.; Laboratory of Growth Regulators, The Czech Academy of Sciences & Faculty of Science, Institute of Experimental Botany, Palacký University, Šlechtitelů 27, Olomouc, 78371, Czech Republic., Ljung K; Umeå Plant Science Centre, Department of Forest Genetics and Plant Physiology, Swedish University of Agricultural Sciences, Umea, SE-901 83, Sweden., Bulder S; Bejo Zaden B.V., Trambaan 1, Warmenhuizen, 1749 CZ, the Netherlands., van Verk M; Plant-Microbe Interactions, Institute of Environmental Biology, Utrecht University, Padualaan 8, Utrecht, 3584 CH, the Netherlands.; Keygene, Agro Business Park 90, Wageningen, 6708 PW, the Netherlands.; Theoretical Biology and Bioinformatics, Institute of Biodynamics and Biocomplexity, Utrecht University, Padualaan 8, Utrecht, 3584 CH, the Netherlands., Snoek BL; Theoretical Biology and Bioinformatics, Institute of Biodynamics and Biocomplexity, Utrecht University, Padualaan 8, Utrecht, 3584 CH, the Netherlands., Fiers M; Bioscience, Wageningen University and Research, Droevendaalsesteeg 1, Wageningen, 6708 PB, the Netherlands., Martin NI; Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, University Utrecht, Universiteitsweg 99, Utrecht, 3584 CG, the Netherlands.; Biological Chemistry Group, Sylvius Laboratories, Institute of Biology Leiden, Leiden University, Sylviusweg 72, Leiden, 2333 BE, the Netherlands., van der Hoorn RAL; Plant Chemetics Laboratory, Department of Plant Sciences, University of Oxford, South Parks Road, Oxford, OX1 3RB, UK., Robert S; Umeå Plant Science Centre, Department of Forest Genetics and Plant Physiology, Swedish University of Agricultural Sciences, Umea, SE-901 83, Sweden., Smeekens S; Molecular Plant Physiology, Institute of Environmental Biology, Utrecht University, Padualaan 8, Utrecht, 3584 CH, the Netherlands., van Zanten M; Molecular Plant Physiology, Institute of Environmental Biology, Utrecht University, Padualaan 8, Utrecht, 3584 CH, the Netherlands.
المصدر: The Plant journal : for cell and molecular biology [Plant J] 2021 Jun; Vol. 106 (6), pp. 1523-1540. Date of Electronic Publication: 2021 May 06.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Blackwell Scientific Publishers and BIOS Scientific Publishers in association with the Society for Experimental Biology Country of Publication: England NLM ID: 9207397 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-313X (Electronic) Linking ISSN: 09607412 NLM ISO Abbreviation: Plant J Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Oxford : Blackwell Scientific Publishers and BIOS Scientific Publishers in association with the Society for Experimental Biology, c1991-
مواضيع طبية MeSH: Aminohydrolases/*metabolism , Arabidopsis/*drug effects , Enzyme Inhibitors/*pharmacology , Gene Expression Regulation, Plant/*drug effects , Hypocotyl/*drug effects, Aldehyde Oxidase/genetics ; Aldehyde Oxidase/metabolism ; Aminohydrolases/genetics ; Apomorphine/analogs & derivatives ; Apomorphine/pharmacology ; Arabidopsis/growth & development ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; Enzyme Inhibitors/administration & dosage ; Enzyme Inhibitors/chemistry ; Herbicides/pharmacology ; Hypocotyl/growth & development ; Indoleacetic Acids ; Molecular Structure ; Picloram/pharmacology ; Structure-Activity Relationship ; Transcriptome/drug effects
مستخلص: Temperature passively affects biological processes involved in plant growth. Therefore, it is challenging to study the dedicated temperature signalling pathways that orchestrate thermomorphogenesis, a suite of elongation growth-based adaptations that enhance leaf-cooling capacity. We screened a chemical library for compounds that restored hypocotyl elongation in the pif4-2-deficient mutant background at warm temperature conditions in Arabidopsis thaliana to identify modulators of thermomorphogenesis. The small aromatic compound 'Heatin', containing 1-iminomethyl-2-naphthol as a pharmacophore, was selected as an enhancer of elongation growth. We show that ARABIDOPSIS ALDEHYDE OXIDASES redundantly contribute to Heatin-mediated hypocotyl elongation. Following a chemical proteomics approach, the members of the NITRILASE1-subfamily of auxin biosynthesis enzymes were identified among the molecular targets of Heatin. Our data reveal that nitrilases are involved in promotion of hypocotyl elongation in response to high temperature and Heatin-mediated hypocotyl elongation requires the NITRILASE1-subfamily members, NIT1 and NIT2. Heatin inhibits NIT1-subfamily enzymatic activity in vitro and the application of Heatin accordingly results in the accumulation of NIT1-subfamily substrate indole-3-acetonitrile in vivo. However, levels of the NIT1-subfamily product, bioactive auxin (indole-3-acetic acid), were also significantly increased. It is likely that the stimulation of hypocotyl elongation by Heatin might be independent of its observed interaction with NITRILASE1-subfamily members. However, nitrilases may contribute to the Heatin response by stimulating indole-3-acetic acid biosynthesis in an indirect way. Heatin and its functional analogues present novel chemical entities for studying auxin biology.
(© 2021 The Authors. The Plant Journal published by Society for Experimental Biology and John Wiley & Sons Ltd.)
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معلومات مُعتمدة: 616449 H2020 European Research Council; 258413 H2020 European Research Council; Swedish Research Council; 831.13.002 Netherlands Organisation for Scientific research (NWO); INST 20876/127-1 Deutsche Forschungsgemeinschaft (DFG); BB/R017913/1 BBSRC; BB/S003193/1 BBSRC; Swedish Metabolomics Centre for the Use of Instrumentation; Knut and Alice Wallenberg Foundation (KAW); CZ.02.1.01/0.0/0.0/16_019/0000827 Ministry of Education Youth and Sports of the Czech Republic; Swedish Foundation for Strategic Research
فهرسة مساهمة: Keywords: 1-iminomethyl-2-naphthol; Arabidopsis; Heatin; IAN; NIT1-subfamily; PIF4; aldehyde oxidase; chemical genetics; indole-3-acetonitrile; nitrilases; thermomorphogenesis
المشرفين على المادة: 0 (10,11-dihydroxy-N-n-propylnorapomorphine)
0 (Arabidopsis Proteins)
0 (Enzyme Inhibitors)
0 (Herbicides)
0 (Indoleacetic Acids)
EC 1.2.3.1 (AAO1 protein, Arabidopsis)
EC 1.2.3.1 (Aldehyde Oxidase)
EC 3.5.4.- (Aminohydrolases)
EC 3.5.5.1 (nitrilase)
N21FAR7B4S (Apomorphine)
O7437X49DW (Picloram)
تواريخ الأحداث: Date Created: 20210326 Date Completed: 20211215 Latest Revision: 20211215
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC8360157
DOI: 10.1111/tpj.15250
PMID: 33768644
قاعدة البيانات: MEDLINE
الوصف
تدمد:1365-313X
DOI:10.1111/tpj.15250