دورية أكاديمية
أعرض في EDS

Clinical and laboratory features of patients with focal lymphocytic sialadenitis on minor salivary gland biopsy for sicca symptoms: A single-center experience.

التفاصيل البيبلوغرافية
العنوان: Clinical and laboratory features of patients with focal lymphocytic sialadenitis on minor salivary gland biopsy for sicca symptoms: A single-center experience.
المؤلفون: Ayesha B; Albert Einstein College of Medicine, Montefiore Medical Center, New York, NY., Fernandez-Ruiz R; Department of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA.; Division of Rheumatology, New York University Langone Health, New York, NY., Shrock D; Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA., Snyder BM; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN., Lieberman SM; Division of Rheumatology, Allergy, and Immunology., Tuetken R; Division of Immunology, University of Iowa Hospitals and Clinics., Field E; Division of Immunology, University of Iowa Hospitals and Clinics and VA Medical Center, Iowa City, IA., Singh N; Division of Rheumatology, University of Washington School of Medicine, Seattle, Washington.
المصدر: Medicine [Medicine (Baltimore)] 2021 Apr 02; Vol. 100 (13), pp. e25325.
نوع المنشور: Evaluation Study; Journal Article
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 2985248R Publication Model: Print Cited Medium: Internet ISSN: 1536-5964 (Electronic) Linking ISSN: 00257974 NLM ISO Abbreviation: Medicine (Baltimore) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Hagerstown, Md : Lippincott Williams & Wilkins
مواضيع طبية MeSH: Autoantibodies/*analysis , Biopsy/*methods , Salivary Glands, Minor/*pathology , Sialadenitis/*diagnosis , Sjogren's Syndrome/*diagnosis, Adult ; Cross-Sectional Studies ; Diagnosis, Differential ; Dry Eye Syndromes/diagnosis ; Female ; Humans ; Male ; Middle Aged ; Odds Ratio ; Young Adult
مستخلص: Abstract: Minor salivary gland biopsy (MSGB) is often used in patients lacking specific autoantibodies (seronegative patients) to confirm the presence of focal lymphocytic sialadenitis (FLS), which would suggest a diagnosis of Sjogren syndrome. There are no current guidelines indicating when to refer patients for MSGB. The objective of our study was to ascertain distinguishing clinical and laboratory features among individuals with sicca symptoms based on their serologic and histopathologic status, and to identify factors associated with FLS.Using a cross-sectional study design, patients ages 18 years or older with sicca symptoms who had MSGB performed at the University of Iowa from January 2000 to December 2016 were selected for chart reviews. The clinical and laboratory features of patients with and without FLS were analyzed using exact univariate and multivariable logistic regression, with Bonferroni correction for multiple comparisons.We identified 177 patients who had MSGB performed and available clinical data. A total of 133 patients had FLS, 37 (27.8%) were seropositive (positive-anti-Sjogren syndrome type A [SSA] and/or anti-Sjogren syndrome type B) and 96 (72.2%) were seronegative. Dry eyes (unadjusted odds ratio [OR]: 5.17, 95% confidence interval [CI]: 1.16-26.30; adjusted odds ratio [aOR]: 12.58, 95% CI: 1.70-167.77) and the presence of anti-SSA (OR: 7.16, 95% CI: 1.70-64.24; aOR: 8.82, 95% CI: 1.73-93.93) were associated with FLS. Smoking (aOR 0.27, 95% CI: 0.11-0.63) and antihistamine use (aOR 0.23, 95% CI: 0.08-0.63) were associated with lower odds of FLS.Our study suggests that dry eyes and anti-SSA positivity are associated with FLS. Smoking and antihistamine use were associated with lower odds of FLS. In the appropriate clinical context, seronegative patients with sicca symptoms and no smoking history could be considered for MSGB. A thorough medication and smoking history should be performed in all patients before referral for MSGB.
Competing Interests: The authors have no conflicts of interest to declare.
(Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.)
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المشرفين على المادة: 0 (Autoantibodies)
تواريخ الأحداث: Date Created: 20210331 Date Completed: 20210413 Latest Revision: 20230103
رمز التحديث: 20230103
مُعرف محوري في PubMed: PMC8021287
DOI: 10.1097/MD.0000000000025325
PMID: 33787627
قاعدة البيانات: MEDLINE
الوصف
تدمد:1536-5964
DOI:10.1097/MD.0000000000025325