دورية أكاديمية
أعرض في EDS

Mitochondria antioxidant protection against cardiovascular dysfunction programmed by early-onset gestational hypoxia.

التفاصيل البيبلوغرافية
العنوان: Mitochondria antioxidant protection against cardiovascular dysfunction programmed by early-onset gestational hypoxia.
المؤلفون: Spiroski AM; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.; Cambridge Cardiovascular Strategic Research Initiative, Cambridge, UK., Niu Y; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.; Cambridge Cardiovascular Strategic Research Initiative, Cambridge, UK., Nicholas LM; Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., Austin-Williams S; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., Camm EJ; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., Sutherland MR; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., Ashmore TJ; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., Skeffington KL; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., Logan A; Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK., Ozanne SE; Cambridge Cardiovascular Strategic Research Initiative, Cambridge, UK.; Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.; Strategic Research Initiative in Reproduction, Cambridge, UK., Murphy MP; Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.; Department of Medicine, University of Cambridge, Cambridge, UK., Giussani DA; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.; Cambridge Cardiovascular Strategic Research Initiative, Cambridge, UK.; Strategic Research Initiative in Reproduction, Cambridge, UK.
المصدر: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2021 May; Vol. 35 (5), pp. e21446.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print Cited Medium: Internet ISSN: 1530-6860 (Electronic) Linking ISSN: 08926638 NLM ISO Abbreviation: FASEB J Subsets: MEDLINE
أسماء مطبوعة: Publication: 2020- : [Bethesda, Md.] : Hoboken, NJ : Federation of American Societies for Experimental Biology ; Wiley
Original Publication: [Bethesda, Md.] : The Federation, [c1987-
مواضيع طبية MeSH: Oxidative Stress*, Antioxidants/*pharmacology , Cardiovascular Diseases/*prevention & control , Fetal Hypoxia/*complications , Mitochondria/*metabolism , Prenatal Exposure Delayed Effects/*prevention & control, Animals ; Animals, Newborn ; Calcium/metabolism ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/pathology ; Female ; Male ; Pregnancy ; Prenatal Exposure Delayed Effects/etiology ; Prenatal Exposure Delayed Effects/pathology ; Rats ; Rats, Wistar
مستخلص: Mitochondria-derived oxidative stress during fetal development increases cardiovascular risk in adult offspring of pregnancies complicated by chronic fetal hypoxia. We investigated the efficacy of the mitochondria-targeted antioxidant MitoQ in preventing cardiovascular dysfunction in adult rat offspring exposed to gestational hypoxia, integrating functional experiments in vivo, with those at the isolated organ and molecular levels. Rats were randomized to normoxic or hypoxic (13%-14% O 2 ) pregnancy ± MitoQ (500 μM day -1 ) in the maternal drinking water. At 4 months of age, one cohort of male offspring was chronically instrumented with vascular catheters and flow probes to test in vivo cardiovascular function. In a second cohort, the heart was isolated and mounted onto a Langendorff preparation. To establish mechanisms linking gestational hypoxia with cardiovascular dysfunction and protection by MitoQ, we quantified the expression of antioxidant system, β-adrenergic signaling, and calcium handling genes in the fetus and adult, in frozen tissues from a third cohort. Maternal MitoQ in hypoxic pregnancy protected offspring against increased α 1 -adrenergic reactivity of the cardiovascular system, enhanced reactive hyperemia in peripheral vascular beds, and sympathetic dominance, hypercontractility and diastolic dysfunction in the heart. Inhibition of Nfe2l2-mediated oxidative stress in the fetal heart and preservation of calcium regulatory responses in the hearts of fetal and adult offspring link molecular mechanisms to the protective actions of MitoQ treatment of hypoxic pregnancy. Therefore, these data show the efficacy of MitoQ in buffering mitochondrial stress through NADPH-induced oxidative damage and the prevention of programmed cardiovascular disease in adult offspring of hypoxic pregnancy.
(© 2021 The Authors. The FASEB Journal published by Wiley Periodicals LLC on behalf of Federation of American Societies for Experimental Biology.)
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معلومات مُعتمدة: MC_UU_12012/4 United Kingdom MRC_ Medical Research Council; RG/17/8/32924 United Kingdom BHF_ British Heart Foundation; RG/17/12/33167 United Kingdom BHF_ British Heart Foundation; MC_U105663142 United Kingdom MRC_ Medical Research Council; PG/14/5/30547 United Kingdom BHF_ British Heart Foundation; 110159 United Kingdom WT_ Wellcome Trust; MC_U105663142 Medical Research Council UK; MC_UU_00014/4 Medical Research Council UK; United Kingdom WT_ Wellcome Trust; 110158/Z/15/Z United Kingdom WT_ Wellcome Trust; MC_UU_00014/4 United Kingdom MRC_ Medical Research Council; 110159/A/15/Z United Kingdom WT_ Wellcome Trust
فهرسة مساهمة: Keywords: IUGR; cardiovascular; fetus; hypoxia; mitochondria; oxidative stress; programming
المشرفين على المادة: 0 (Antioxidants)
SY7Q814VUP (Calcium)
تواريخ الأحداث: Date Created: 20210331 Date Completed: 20210719 Latest Revision: 20230315
رمز التحديث: 20230315
مُعرف محوري في PubMed: PMC7612077
DOI: 10.1096/fj.202002705R
PMID: 33788974
قاعدة البيانات: MEDLINE
الوصف
تدمد:1530-6860
DOI:10.1096/fj.202002705R