دورية أكاديمية
أعرض في EDS

Role of the Peroxisome Proliferator Activated Receptors in Hypertension.

التفاصيل البيبلوغرافية
العنوان: Role of the Peroxisome Proliferator Activated Receptors in Hypertension.
المؤلفون: Fang S; Department of Physiology, Cardiovascular Center (S.F., P.N., J.W., C.D.S.), Medical College of Wisconsin, Milwaukee.; Department of Neuroscience and Pharmacology, University of Iowa (S.F.)., Livergood MC; Department of Obstetrics and Gynecology (M.C.L.), Medical College of Wisconsin, Milwaukee., Nakagawa P; Department of Physiology, Cardiovascular Center (S.F., P.N., J.W., C.D.S.), Medical College of Wisconsin, Milwaukee., Wu J; Department of Physiology, Cardiovascular Center (S.F., P.N., J.W., C.D.S.), Medical College of Wisconsin, Milwaukee., Sigmund CD; Department of Physiology, Cardiovascular Center (S.F., P.N., J.W., C.D.S.), Medical College of Wisconsin, Milwaukee.
المصدر: Circulation research [Circ Res] 2021 Apr 02; Vol. 128 (7), pp. 1021-1039. Date of Electronic Publication: 2021 Apr 01.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0047103 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4571 (Electronic) Linking ISSN: 00097330 NLM ISO Abbreviation: Circ Res Subsets: MEDLINE
أسماء مطبوعة: Publication: Baltimore, MD : Lippincott Williams & Wilkins
Original Publication: Baltimore, Md. Grune & Stratton.
مواضيع طبية MeSH: Blood Pressure/*physiology , Hypertension/*genetics , Peroxisome Proliferator-Activated Receptors/*physiology, Animals ; Brain/metabolism ; Female ; Humans ; Immune System/physiology ; Kidney/metabolism ; Mice ; PPAR gamma/genetics ; PPAR gamma/physiology ; Peroxisome Proliferator-Activated Receptors/genetics ; Placenta ; Pre-Eclampsia/etiology ; Pregnancy ; Rats ; Research ; Transcription Factors/physiology
مستخلص: Nuclear receptors represent a large family of ligand-activated transcription factors which sense the physiological environment and make long-term adaptations by mediating changes in gene expression. In this review, we will first discuss the fundamental mechanisms by which nuclear receptors mediate their transcriptional responses. We will focus on the PPAR (peroxisome proliferator-activated receptor) family of adopted orphan receptors paying special attention to PPARγ, the isoform with the most compelling evidence as an important regulator of arterial blood pressure. We will review genetic data showing that rare mutations in PPARγ cause severe hypertension and clinical trial data which show that PPARγ activators have beneficial effects on blood pressure. We will detail the tissue- and cell-specific molecular mechanisms by which PPARs in the brain, kidney, vasculature, and immune system modulate blood pressure and related phenotypes, such as endothelial function. Finally, we will discuss the role of placental PPARs in preeclampsia, a life threatening form of hypertension during pregnancy. We will close with a viewpoint on future research directions and implications for developing novel therapies.
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معلومات مُعتمدة: K01 DK126792 United States DK NIDDK NIH HHS; K01 HL153101 United States HL NHLBI NIH HHS; R35 HL144807 United States HL NHLBI NIH HHS; T32 HL134643 United States HL NHLBI NIH HHS; P01 HL084207 United States HL NHLBI NIH HHS
فهرسة مساهمة: Keywords: blood pressure; gene expression; hypertension; preeclampsia; pregnancy
المشرفين على المادة: 0 (PPAR gamma)
0 (Peroxisome Proliferator-Activated Receptors)
0 (Transcription Factors)
تواريخ الأحداث: Date Created: 20210401 Date Completed: 20211229 Latest Revision: 20220805
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC8020861
DOI: 10.1161/CIRCRESAHA.120.318062
PMID: 33793338
قاعدة البيانات: MEDLINE
الوصف
تدمد:1524-4571
DOI:10.1161/CIRCRESAHA.120.318062