دورية أكاديمية
Role of the Peroxisome Proliferator Activated Receptors in Hypertension.
العنوان: | Role of the Peroxisome Proliferator Activated Receptors in Hypertension. |
---|---|
المؤلفون: | Fang S; Department of Physiology, Cardiovascular Center (S.F., P.N., J.W., C.D.S.), Medical College of Wisconsin, Milwaukee.; Department of Neuroscience and Pharmacology, University of Iowa (S.F.)., Livergood MC; Department of Obstetrics and Gynecology (M.C.L.), Medical College of Wisconsin, Milwaukee., Nakagawa P; Department of Physiology, Cardiovascular Center (S.F., P.N., J.W., C.D.S.), Medical College of Wisconsin, Milwaukee., Wu J; Department of Physiology, Cardiovascular Center (S.F., P.N., J.W., C.D.S.), Medical College of Wisconsin, Milwaukee., Sigmund CD; Department of Physiology, Cardiovascular Center (S.F., P.N., J.W., C.D.S.), Medical College of Wisconsin, Milwaukee. |
المصدر: | Circulation research [Circ Res] 2021 Apr 02; Vol. 128 (7), pp. 1021-1039. Date of Electronic Publication: 2021 Apr 01. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
اللغة: | English |
بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0047103 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4571 (Electronic) Linking ISSN: 00097330 NLM ISO Abbreviation: Circ Res Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Baltimore, MD : Lippincott Williams & Wilkins Original Publication: Baltimore, Md. Grune & Stratton. |
مواضيع طبية MeSH: | Blood Pressure/*physiology , Hypertension/*genetics , Peroxisome Proliferator-Activated Receptors/*physiology, Animals ; Brain/metabolism ; Female ; Humans ; Immune System/physiology ; Kidney/metabolism ; Mice ; PPAR gamma/genetics ; PPAR gamma/physiology ; Peroxisome Proliferator-Activated Receptors/genetics ; Placenta ; Pre-Eclampsia/etiology ; Pregnancy ; Rats ; Research ; Transcription Factors/physiology |
مستخلص: | Nuclear receptors represent a large family of ligand-activated transcription factors which sense the physiological environment and make long-term adaptations by mediating changes in gene expression. In this review, we will first discuss the fundamental mechanisms by which nuclear receptors mediate their transcriptional responses. We will focus on the PPAR (peroxisome proliferator-activated receptor) family of adopted orphan receptors paying special attention to PPARγ, the isoform with the most compelling evidence as an important regulator of arterial blood pressure. We will review genetic data showing that rare mutations in PPARγ cause severe hypertension and clinical trial data which show that PPARγ activators have beneficial effects on blood pressure. We will detail the tissue- and cell-specific molecular mechanisms by which PPARs in the brain, kidney, vasculature, and immune system modulate blood pressure and related phenotypes, such as endothelial function. Finally, we will discuss the role of placental PPARs in preeclampsia, a life threatening form of hypertension during pregnancy. We will close with a viewpoint on future research directions and implications for developing novel therapies. |
References: | Am J Hypertens. 1997 Sep;10(9 Pt 1):1027-33. (PMID: 9324109) Hypertension. 2007 Jan;49(1):27-33. (PMID: 17116758) J Immunol. 2000 Feb 1;164(3):1364-71. (PMID: 10640751) Hypertension. 2011 Nov;58(5):882-7. (PMID: 21931072) Hypertension. 2015 Apr;65(4):896-902. (PMID: 25691623) JCI Insight. 2019 Jun 11;5:. (PMID: 31184598) J Biol Chem. 2002 Mar 1;277(9):6838-45. (PMID: 11726654) J Cardiovasc Pharmacol. 2012 Jun;59(6):563-9. (PMID: 22361751) J Biol Chem. 2010 Dec 24;285(52):40409-15. (PMID: 20956526) Endocrinology. 2001 Oct;142(10):4504-14. (PMID: 11564716) Br J Pharmacol. 2019 Aug;176(16):2945-2961. (PMID: 31144304) Circulation. 2000 Oct 10;102(15):1834-9. (PMID: 11023940) Circ Res. 2008 Sep 12;103(6):654-61. (PMID: 18676352) Hypertension. 2014 Jul;64(1):178-84. (PMID: 24799612) Circ Res. 2006 Apr 14;98(7):e50-9. (PMID: 16556873) Circ Res. 2013 Mar 1;112(5):781-91. (PMID: 23303165) J Biol Chem. 1998 Dec 4;273(49):32833-41. (PMID: 9830030) Am J Physiol Heart Circ Physiol. 2009 Nov;297(5):H1647-54. (PMID: 19666848) J Hypertens. 2013 Apr;31(4):820-9. (PMID: 23385647) Acta Pharmacol Sin. 2014 Apr;35(4):476-82. (PMID: 24562305) Diabetes Care. 2010 Feb;33(2):215-20. (PMID: 19846798) J Hypertens. 2008 Mar;26(3):468-77. (PMID: 18300857) J Biol Chem. 2000 Jul 21;275(29):22435-41. (PMID: 10801895) Nature. 2005 Sep 29;437(7059):759-63. (PMID: 16127449) Diabetes. 2002 Feb;51(2):439-42. (PMID: 11812752) Placenta. 2010 Mar;31(3):222-9. (PMID: 20045185) Am J Hypertens. 2006 Nov;19(11):1174-80. (PMID: 17070431) Mol Cell Biol. 2002 Jul;22(14):5114-27. (PMID: 12077340) Circulation. 2011 Sep 20;124(12):1370-81. (PMID: 21875910) J Am Soc Nephrol. 2009 Apr;20(4):721-9. (PMID: 19158355) J Biol Chem. 1995 Jun 2;270(22):12953-6. (PMID: 7768881) Nat Med. 2011 Aug 28;17(9):1121-7. (PMID: 21873987) Tex Rep Biol Med. 1967 Summer;25(2):257-64. (PMID: 6040652) J Am Soc Nephrol. 2019 May;30(5):811-823. (PMID: 30967423) Hypertension. 2010 Feb;55(2):437-44. (PMID: 20038751) Hypertension. 2017 Sep;70(3):559-565. (PMID: 28674038) Am J Physiol. 1993 Oct;265(4 Pt 2):R726-32. (PMID: 8238439) Am J Hypertens. 2005 Apr;18(4 Pt 1):549-56. (PMID: 15831367) Neurosci Bull. 2019 Feb;35(1):15-24. (PMID: 30173356) Nat Med. 2011 May;17(5):618-22. (PMID: 21532596) Hypertension. 2016 Aug;68(2):491-500. (PMID: 27296999) Diabetes. 2012 Dec;61(12):3285-93. (PMID: 22933110) Hypertension. 2010 Jun;55(6):1444-53. (PMID: 20404217) Arterioscler Thromb Vasc Biol. 2008 Dec;28(12):2312-8. (PMID: 18818415) Am J Hypertens. 1995 Mar;8(3):316-20. (PMID: 7794582) Hypertension. 2003 Oct;42(4):737-43. (PMID: 12860836) Pregnancy Hypertens. 2014 Jul;4(3):187-93. (PMID: 26104604) Circ Res. 2005 Oct 14;97(8):772-80. (PMID: 16151022) J Mol Cell Cardiol. 2004 Feb;36(2):295-304. (PMID: 14871557) Lancet. 2005 Oct 8;366(9493):1279-89. (PMID: 16214598) J Pharmacol Exp Ther. 2006 Apr;317(1):11-8. (PMID: 16339392) Physiol Genomics. 2017 Nov 1;49(11):653-658. (PMID: 28916634) Diabetes. 1994 Feb;43(2):204-11. (PMID: 8288044) Circulation. 2002 May 14;105(19):2296-302. (PMID: 12010913) Nat Med. 2005 Aug;11(8):861-6. (PMID: 16007095) Hypertension. 2019 Jul;74(1):173-183. (PMID: 31104564) J Clin Invest. 2019 Mar 21;129(6):2318-2332. (PMID: 30896450) Circ Res. 1999 Sep 3;85(5):394-402. (PMID: 10473669) Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):303-8. (PMID: 11756685) Mol Immunol. 2007 Feb;44(6):1218-29. (PMID: 16949670) J Clin Invest. 2000 Sep;106(6):793-802. (PMID: 10995790) Arch Intern Med. 2010 Jul 26;170(14):1191-1201. (PMID: 20656674) Atherosclerosis. 2018 Jul;274:199-205. (PMID: 29800789) Genes Dev. 2008 Nov 1;22(21):2953-67. (PMID: 18981474) Hypertension. 2004 Mar;43(3):661-6. (PMID: 14744930) Arthritis Res Ther. 2017 Dec 06;19(1):268. (PMID: 29208022) Metabolism. 2001 Jan;50(1):3-11. (PMID: 11172467) Nature. 2010 Jul 22;466(7305):451-6. (PMID: 20651683) Endocrinology. 2016 Nov;157(11):4266-4275. (PMID: 27575030) Cardiovasc Res. 2021 Jan 1;117(1):308-319. (PMID: 32428209) Nature. 1998 Jan 1;391(6662):79-82. (PMID: 9422508) Am J Physiol Regul Integr Comp Physiol. 2013 Sep 15;305(6):R566-81. (PMID: 23883674) Mol Cell. 2009 Sep 24;35(6):841-55. (PMID: 19782033) Physiol Genomics. 2016 Jul 1;48(7):491-501. (PMID: 27199455) Biochem Biophys Res Commun. 1999 Jan 27;254(3):757-63. (PMID: 9920814) Lancet. 1994 Feb 5;343(8893):340-1. (PMID: 7905151) Oxid Med Cell Longev. 2018 Jun 25;2018:5852706. (PMID: 30046379) Nature. 2012 Jan 22;482(7383):98-102. (PMID: 22266938) J Clin Endocrinol Metab. 2000 Oct;85(10):3808-14. (PMID: 11061543) Sci Transl Med. 2015 Jun 3;7(290):290ra88. (PMID: 26041705) Hypertension. 2017 Apr;69(4):641-650. (PMID: 28242713) Hypertension. 2014 Nov;64(5):1088-93. (PMID: 25185134) Hypertension. 1993 Jun;21(6 Pt 2):985-8. (PMID: 8505111) J Cardiovasc Pharmacol. 2014 Dec;64(6):497-506. (PMID: 25490415) Hypertension. 1993 Jun;21(6 Pt 2):1020-3. (PMID: 8505086) J Clin Invest. 2014 Sep;124(9):4017-27. (PMID: 25083994) Hypertension. 2002 Dec;40(6):866-71. (PMID: 12468571) J Atheroscler Thromb. 2014;21(6):563-73. (PMID: 24477028) Lab Invest. 2003 Dec;83(12):1715-21. (PMID: 14691289) Hypertension. 2011 Mar;57(3):469-76. (PMID: 21263125) Front Physiol. 2013 Jul 23;4:184. (PMID: 23888144) Mol Cell. 1999 Oct;4(4):585-95. (PMID: 10549290) Stem Cells Dev. 2013 Nov 1;22(21):2815-24. (PMID: 23767827) N Engl J Med. 1994 Nov 3;331(18):1188-93. (PMID: 7935656) Cancer Chemother Pharmacol. 2013 Apr;71(4):929-36. (PMID: 23358645) J Neuroimmunol. 2018 Aug 15;321:72-82. (PMID: 29957391) J Clin Endocrinol Metab. 2002 Dec;87(12):5503-6. (PMID: 12466345) Immunology. 2017 Dec;152(4):648-659. (PMID: 28763099) Circulation. 2000 Mar 21;101(11):1311-8. (PMID: 10725292) Circ Res. 2009 Oct 23;105(9):886-96. (PMID: 19762685) Nature. 2012 Jun 28;486(7404):549-53. (PMID: 22722857) Circ Res. 2002 Apr 5;90(6):703-10. (PMID: 11934839) Hypertension. 2018 Nov;72(5):1227-1235. (PMID: 30354810) Proc Natl Acad Sci U S A. 2005 Jun 28;102(26):9406-11. (PMID: 15956187) Nat Med. 2001 Jan;7(1):48-52. (PMID: 11135615) Circ Res. 2012 Jan 6;110(1):8-11. (PMID: 22223206) J Soc Gynecol Investig. 2005 Jul;12(5):320-9. (PMID: 15979543) Nature. 2011 Sep 04;477(7365):477-81. (PMID: 21892191) Hypertension. 2017 Jul;70(1):174-182. (PMID: 28507170) Diabetes. 2017 Feb;66(2):519-528. (PMID: 27856609) Toxicol Appl Pharmacol. 2016 Aug 15;305:93-102. (PMID: 27292124) Obstet Gynecol. 2020 Jun;135(6):e237-e260. (PMID: 32443079) Arterioscler Thromb Vasc Biol. 2003 Jan 1;23(1):45-51. (PMID: 12524223) Endocrinology. 2009 Feb;150(2):707-12. (PMID: 18845632) Hypertension. 2018 Feb;71(2):297-305. (PMID: 29295852) Eur J Clin Invest. 2021 Feb;51(2):e13377. (PMID: 32914429) Mol Cell Biol. 2005 Jan;25(1):162-71. (PMID: 15601839) Immunology. 2014 Jul;142(3):363-73. (PMID: 24456224) Circ Res. 2008 Jul 18;103(2):186-93. (PMID: 18566341) Diabetes Care. 2006 Feb;29(2):195-201. (PMID: 16443859) Arterioscler Thromb Vasc Biol. 2004 Apr;24(4):658-63. (PMID: 14751809) JCI Insight. 2017 Dec 21;2(24):. (PMID: 29263298) J Immunol. 2009 Jan 1;182(1):340-6. (PMID: 19109165) Kidney Int. 2008 Oct;74(8):1040-8. (PMID: 18596730) Diabetes. 1999 Jul;48(7):1448-53. (PMID: 10389852) Physiol Res. 2012;61(5):443-52. (PMID: 22881223) Hypertension. 2012 Feb;59(2):477-84. (PMID: 22083161) Arterioscler Thromb Vasc Biol. 2013 Apr;33(4):829-38. (PMID: 23393388) Nat Genet. 2018 Oct;50(10):1412-1425. (PMID: 30224653) Steroids. 2010 Nov;75(11):794-9. (PMID: 19883672) Nat Commun. 2012;3:1300. (PMID: 23250430) J Exp Med. 2007 Oct 1;204(10):2449-60. (PMID: 17875676) J Pharmacol Exp Ther. 2004 Feb;308(2):426-33. (PMID: 14593089) Arterioscler Thromb Vasc Biol. 2010 Mar;30(3):518-25. (PMID: 20018933) J Am Soc Nephrol. 2005 Aug;16(8):2395-402. (PMID: 15944338) J Clin Endocrinol Metab. 2005 Feb;90(2):620-6. (PMID: 15562025) Biosci Rep. 2019 Feb 27;39(2):. (PMID: 30777927) Nature. 2007 Jun 28;447(7148):1116-20. (PMID: 17515919) Placenta. 2007 Apr;28 Suppl A:S76-81. (PMID: 17321592) Am J Physiol Renal Physiol. 2012 Mar 1;302(5):F540-51. (PMID: 22169011) Nat Med. 2011 May;17(5):623-6. (PMID: 21532595) Hypertension. 2018 Jul;72(1):227-234. (PMID: 29735632) Circ Res. 2010 Oct 15;107(8):953-8. (PMID: 20798360) Hypertension. 2017 Jun;69(6):1198-1206. (PMID: 28461605) J Clin Invest. 2000 May;105(9):1243-52. (PMID: 10791999) J Pharmacol Exp Ther. 2016 Jul;358(1):151-63. (PMID: 27189971) Genesis. 2004 Nov;40(3):139-45. (PMID: 15493015) J Exp Med. 2009 Sep 28;206(10):2079-89. (PMID: 19737866) Circ Res. 2012 Nov 9;111(11):1446-58. (PMID: 22962432) Ann N Y Acad Sci. 2002 Nov;973:26-30. (PMID: 12485829) Nature. 1999 Dec 23-30;402(6764):880-3. (PMID: 10622252) Hypertension. 2015 Feb;65(2):345-51. (PMID: 25385762) Cell Metab. 2012 Oct 3;16(4):462-72. (PMID: 23040068) J Clin Invest. 2004 Jul;114(2):240-9. (PMID: 15254591) Biochem Pharmacol. 2016 Sep 1;115:85-93. (PMID: 27208887) JCI Insight. 2016 Nov 17;1(19):e91015. (PMID: 27882355) Am J Physiol Regul Integr Comp Physiol. 2009 Apr;296(4):R1282-9. (PMID: 19193937) Trends Pharmacol Sci. 2015 Oct;36(10):688-704. (PMID: 26435213) Physiol Genomics. 2016 Feb;48(2):124-34. (PMID: 26534936) Hypertension. 2011 Oct;58(4):733-43. (PMID: 21825230) Am J Physiol Regul Integr Comp Physiol. 2008 Apr;294(4):R1262-7. (PMID: 18256139) J Biol Chem. 2001 Jan 12;276(2):1353-60. (PMID: 11022035) Circ Res. 1973 May;32(5):564-76. (PMID: 4713198) Metabolism. 1995 Sep;44(9):1105-9. (PMID: 7666781) FASEB J. 2003 Dec;17(15):2299-301. (PMID: 14525942) Hypertension. 2015 Jul;66(1):211-20. (PMID: 25916724) Circ Res. 2011 Apr 1;108(7):808-12. (PMID: 21311043) Cardiovasc Res. 2013 Mar 1;97(3):562-70. (PMID: 23250918) Diabetes Care. 2004 Jan;27(1):256-63. (PMID: 14693998) Am J Physiol Heart Circ Physiol. 2016 Jan 1;310(1):H39-48. (PMID: 26566726) Can J Cardiol. 2020 May;36(5):712-720. (PMID: 32389344) Am J Physiol Heart Circ Physiol. 2017 Feb 1;312(2):H189-H200. (PMID: 27881385) Am J Physiol Renal Physiol. 2018 Oct 1;315(4):F1006-F1018. (PMID: 29897280) Mol Pharmacol. 2003 Dec;64(6):1586-90. (PMID: 14645690) Biochim Biophys Acta. 2007 Aug;1771(8):1014-30. (PMID: 17418635) JCI Insight. 2017 Mar 23;2(6):e91738. (PMID: 28352663) Placenta. 2001 Nov;22(10):822-30. (PMID: 11718569) Arterioscler Thromb Vasc Biol. 2005 Aug;25(8):1647-53. (PMID: 15947238) Cardiovasc Drugs Ther. 2009 Oct;23(5):403-8. (PMID: 19757004) PPAR Res. 2011;2011:502631. (PMID: 22190908) Cardiovasc Diabetol. 2008 Apr 24;7:10. (PMID: 18435852) Hypertension. 2015 Aug;66(2):403-11. (PMID: 26101342) Cell Metab. 2008 Mar;7(3):215-26. (PMID: 18316027) Early Hum Dev. 2002 Oct;69(1-2):77-82. (PMID: 12324185) Hypertension. 2016 Jan;67(1):214-22. (PMID: 26597823) Mol Cell Biochem. 2019 Nov;461(1-2):159-170. (PMID: 31420792) |
معلومات مُعتمدة: | K01 DK126792 United States DK NIDDK NIH HHS; K01 HL153101 United States HL NHLBI NIH HHS; R35 HL144807 United States HL NHLBI NIH HHS; T32 HL134643 United States HL NHLBI NIH HHS; P01 HL084207 United States HL NHLBI NIH HHS |
فهرسة مساهمة: | Keywords: blood pressure; gene expression; hypertension; preeclampsia; pregnancy |
المشرفين على المادة: | 0 (PPAR gamma) 0 (Peroxisome Proliferator-Activated Receptors) 0 (Transcription Factors) |
تواريخ الأحداث: | Date Created: 20210401 Date Completed: 20211229 Latest Revision: 20220805 |
رمز التحديث: | 20221213 |
مُعرف محوري في PubMed: | PMC8020861 |
DOI: | 10.1161/CIRCRESAHA.120.318062 |
PMID: | 33793338 |
قاعدة البيانات: | MEDLINE |
كن أول من يترك تعليقا!