دورية أكاديمية
Bacteriocin-Like Inhibitory Substances from Probiotics as Therapeutic Agents for Candida Vulvovaginitis.
العنوان: | Bacteriocin-Like Inhibitory Substances from Probiotics as Therapeutic Agents for Candida Vulvovaginitis. |
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المؤلفون: | Hefzy EM; Department of Medical Microbiology and Immunology, Faculty of Medicine, Fayoum University, Fayoum 63514, Egypt., Khalil MAF; Department of Microbiology and Immunology, Faculty of Pharmacy, Fayoum University, Fayoum 63514, Egypt., Amin AAI; Department of Medical Microbiology and Immunology, Faculty of Medicine, Fayoum University, Fayoum 63514, Egypt., Ashour HM; Department of Integrative Biology, College of Arts and Sciences, University of South Florida, St. Petersburg, FL 33701, USA.; Department of Microbiology and Immunology, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt., Abdelaliem YF; Department of Agricultural Microbiology, Faculty of Agriculture, Fayoum University, Fayoum 63514, Egypt. |
المصدر: | Antibiotics (Basel, Switzerland) [Antibiotics (Basel)] 2021 Mar 17; Vol. 10 (3). Date of Electronic Publication: 2021 Mar 17. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101637404 Publication Model: Electronic Cited Medium: Print ISSN: 2079-6382 (Print) Linking ISSN: 20796382 NLM ISO Abbreviation: Antibiotics (Basel) Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI AG, 2012- |
مستخلص: | Probiotics can potentially prevent and treat diseases. We examined the inhibitory activity of bacteriocin-like inhibitory substances (BLISs) from potentially probiotic lactobacilli and streptococci on Candida albicans and non- Candida albicans clinical isolates from women with vulvovaginitis. Using agar well diffusion assays, BLISs inhibited both Candida albicans and non- Candida albicans isolates. The BLIS from L. pentosus isolates had the highest anti- Candida activity (33/45; 73.3%), followed by BLISs from isolates of L. paracasei subsp. paracasei (31/45; 68.9%), L. rhamnosus I (30/45; 66.7%) , L. delbrueckii subsp. lactis I (30/45; 66.7%), and S. uberis II (30/45; 66.7%). Upon characterization according to the retained activity under variable physical and chemical conditions, the BLISs showed stability against heat, pH, and surfactants, but were protease-sensitive, which suggests a proteinaceous nature of the active substances. Using crystal violet assays, the BLISs reduced the Candida biofilm biomass significantly as compared to a control group that lacked BLISs. In vivo testing of the antagonistic activity was performed using the Galleria mellonella ( G. mellonella ) larvae model. BLISs significantly improved survival in G. mellonella larvae treated with Candida isolates on the first, second, and seventh days, as compared to larvae inoculated with Candida only ( p < 0.01). The results show that BLISs can be used as biotherapeutic agents in vulvovaginal candidiasis. |
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فهرسة مساهمة: | Keywords: Galleria mellonella; bacteriocins; biofilm; vulvovaginitis |
تواريخ الأحداث: | Date Created: 20210403 Latest Revision: 20210413 |
رمز التحديث: | 20221213 |
مُعرف محوري في PubMed: | PMC8002407 |
DOI: | 10.3390/antibiotics10030306 |
PMID: | 33802636 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2079-6382 |
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DOI: | 10.3390/antibiotics10030306 |