دورية أكاديمية
أعرض في EDS

Pemetrexed Hinders Translation Inhibition upon Low Glucose in Non-Small Cell Lung Cancer Cells.

التفاصيل البيبلوغرافية
العنوان: Pemetrexed Hinders Translation Inhibition upon Low Glucose in Non-Small Cell Lung Cancer Cells.
المؤلفون: Piecyk M; Université Lyon, Cancer Research Centre of Lyon, INSERM 1052, CNRS 5286, F-69008 Lyon, France.; Hospices Civils de Lyon, Biopathology of Tumours, CPE, GHE Hospital, F-69500 Bron, France., Triki M; Université Lyon, Cancer Research Centre of Lyon, INSERM 1052, CNRS 5286, F-69008 Lyon, France., Laval PA; Université Lyon, Cancer Research Centre of Lyon, INSERM 1052, CNRS 5286, F-69008 Lyon, France., Dragic H; Université Lyon, Cancer Research Centre of Lyon, INSERM 1052, CNRS 5286, F-69008 Lyon, France., Cussonneau L; Université Clermont Auvergne, INRAE, Unité de Nutrition Humaine, UMR1019, 63122 Clermont-Ferrand, France., Fauvre J; Université Lyon, Cancer Research Centre of Lyon, INSERM 1052, CNRS 5286, F-69008 Lyon, France., Duret C; Université Lyon, Cancer Research Centre of Lyon, INSERM 1052, CNRS 5286, F-69008 Lyon, France., Aznar N; Université Lyon, Cancer Research Centre of Lyon, INSERM 1052, CNRS 5286, F-69008 Lyon, France., Renno T; Université Lyon, Cancer Research Centre of Lyon, INSERM 1052, CNRS 5286, F-69008 Lyon, France., Manié SN; Inserm U1242, Université de Rennes, Centre de Lutte Contre le Cancer Eugène Marquis, 35042 Rennes, France., Chaveroux C; Université Lyon, Cancer Research Centre of Lyon, INSERM 1052, CNRS 5286, F-69008 Lyon, France., Ferraro-Peyret C; Université Lyon, Cancer Research Centre of Lyon, INSERM 1052, CNRS 5286, F-69008 Lyon, France.; Hospices Civils de Lyon, Biopathology of Tumours, CPE, GHE Hospital, F-69500 Bron, France.
المصدر: Metabolites [Metabolites] 2021 Mar 26; Vol. 11 (4). Date of Electronic Publication: 2021 Mar 26.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101578790 Publication Model: Electronic Cited Medium: Print ISSN: 2218-1989 (Print) Linking ISSN: 22181989 NLM ISO Abbreviation: Metabolites Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel : MDPI
مستخلص: Genetic alterations in non-small cell lung cancers (NSCLC) stimulate the generation of energy and biomass to promote tumor development. However, the efficacy of the translation process is finely regulated by stress sensors, themselves often controlled by nutrient availability and chemotoxic agents. Yet, the crosstalk between therapeutic treatment and glucose availability on cell mass generation remains understudied. Herein, we investigated the impact of pemetrexed (PEM) treatment, a first-line agent for NSCLC, on protein synthesis, depending on high or low glucose availability. PEM treatment drastically repressed cell mass and translation when glucose was abundant. Surprisingly, inhibition of protein synthesis caused by low glucose levels was partially dampened upon co-treatment with PEM. Moreover, PEM counteracted the elevation of the endoplasmic reticulum stress (ERS) signal produced upon low glucose availability, providing a molecular explanation for the differential impact of the drug on translation according to glucose levels. Collectively, these data indicate that the ERS constitutes a molecular crosstalk between microenvironmental stressors, contributing to translation reprogramming and proteostasis plasticity.
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فهرسة مساهمة: Keywords: ER stress signaling; NSCLC; glucose availability; pemetrexed; protein synthesis
تواريخ الأحداث: Date Created: 20210403 Latest Revision: 20210428
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC8067050
DOI: 10.3390/metabo11040198
PMID: 33810430
قاعدة البيانات: MEDLINE
الوصف
تدمد:2218-1989
DOI:10.3390/metabo11040198